Andrew Ladwiniec
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View article: Accelerated stress CMR for the detection of significant coronary artery disease: a prospective randomized diagnostic accuracy study
Accelerated stress CMR for the detection of significant coronary artery disease: a prospective randomized diagnostic accuracy study Open
Aims In patients with suspected coronary artery disease (CAD), the role of adenosine-stress cardiovascular magnetic resonance (CMR) is well established. However, to meet increasing demand, improving its time efficiency and cost-effectivene…
View article: Vasoactive breathing manoeuvres as an effective coronary vasodilator in patients with suspected coronary artery disease: a prospective comparative oxygenation-sensitive CMR study
Vasoactive breathing manoeuvres as an effective coronary vasodilator in patients with suspected coronary artery disease: a prospective comparative oxygenation-sensitive CMR study Open
Aims In the assessment of myocardial ischaemia, vasoactive breathing manoeuvres have been proposed as a potential alternative to pharmacological vasodilator stress. However, it remains unclear whether the resultant physiological responses …
View article: Drug-Coated Balloons in the European Registry of Chronic Total Occlusion
Drug-Coated Balloons in the European Registry of Chronic Total Occlusion Open
The use of DCBs in CTO recanalization is increasing and is associated with a reduction in the length of stents implanted, as well as a decrease in contrast volume and a lower rate of pericardial tamponade.
View article: CMR versus CCTA with fractional flow reserve for diagnosing obstructive coronary artery disease in higher risk patients: rationale and design of CONCORD – a prospective, single-centre diagnostic accuracy study
CMR versus CCTA with fractional flow reserve for diagnosing obstructive coronary artery disease in higher risk patients: rationale and design of CONCORD – a prospective, single-centre diagnostic accuracy study Open
CONCORD will comprehensively evaluate two frontline non-invasive functional imaging modalities in patients with suspected angina and determine the comparative accuracy of CCTA/FFRCT and CMR in patients with a moderate-high risk …
View article: Acute Severe Aortic Regurgitation Post-PCI
Acute Severe Aortic Regurgitation Post-PCI Open
The ability to manage more complex coronary disease has evolved with the development of new technologies, techniques, and practitioner experience. The increasing technical difficulty of interventional procedures is known to be associated w…
View article: Accelerated and efficient CMR perfusion assessment for the detection of functionally significant coronary artery disease: A prospective randomized diagnostic accuracy study
Accelerated and efficient CMR perfusion assessment for the detection of functionally significant coronary artery disease: A prospective randomized diagnostic accuracy study Open
View article: Sirolimus-eluting Balloon With Provisional Stenting Versus Systematic Drug-eluting Stent Implantation to Treat De Novo Coronary Lesions. A Randomised, Open-label, Non-inferiority Trial
Sirolimus-eluting Balloon With Provisional Stenting Versus Systematic Drug-eluting Stent Implantation to Treat De Novo Coronary Lesions. A Randomised, Open-label, Non-inferiority Trial Open
View article: The Safety and Efficacy Profile of Magnesium‐Based Bioresorbable Coronary Stents as Compared to Poly‐L‐Lactic Acid–Based Bioresorbable and Contemporary Drug‐Eluting Coronary Stents—A Systematic Review
The Safety and Efficacy Profile of Magnesium‐Based Bioresorbable Coronary Stents as Compared to Poly‐L‐Lactic Acid–Based Bioresorbable and Contemporary Drug‐Eluting Coronary Stents—A Systematic Review Open
Background: Bioresorbable coronary stents (BRS) were designed with the aim of reducing the risk of late adverse events of permanent drug‐eluting stents (DES) by dissolving once vessel patency had been restored and the requirement for acute…
View article: Reclassification of CTO Crossing Strategies in the ERCTO Registry According to the CTO-ARC Consensus Recommendations
Reclassification of CTO Crossing Strategies in the ERCTO Registry According to the CTO-ARC Consensus Recommendations Open
The application of CTO-ARC definitions allowed the reclassification of 6.7% of procedures as alternative antegrade crossing with retrograde or antegrade contribution which showed higher MACCE and lower technical success rates, as compared …
View article: Safety and Effectiveness of a Novel Microcatheter in Coronary Chronic Total Occlusions—The BIOMICS Study
Safety and Effectiveness of a Novel Microcatheter in Coronary Chronic Total Occlusions—The BIOMICS Study Open
View article: Impact of Anatomical and Viability-Guided Completeness of Revascularization on Clinical Outcomes in Ischemic Cardiomyopathy
Impact of Anatomical and Viability-Guided Completeness of Revascularization on Clinical Outcomes in Ischemic Cardiomyopathy Open
In patients with severe LV dysfunction, neither complete anatomical nor viability-guided revascularization was associated with improved event-free survival compared with incomplete revascularization or treatment with medical therapy alone.…
View article: Effect of PCI on Health Status in Ischemic Left Ventricular Dysfunction
Effect of PCI on Health Status in Ischemic Left Ventricular Dysfunction Open
PCI did not improve the hierarchical composite of death, HHF, and health status at 2 years. PCI improved KCCQ-OSS at 6 months, but this benefit was not sustained to 1- or 2-year follow-up. (Revacularization for Ischemic Ventricular Dysfunc…
View article: Complex Percutaneous Coronary Intervention in Patients Unable to Undergo Coronary Artery Bypass Grafting During the COVID-19 Pandemic: Insights From the UK-ReVasc Registry
Complex Percutaneous Coronary Intervention in Patients Unable to Undergo Coronary Artery Bypass Grafting During the COVID-19 Pandemic: Insights From the UK-ReVasc Registry Open
In patients with patterns of coronary disease in whom CABG would have been the primary therapeutic choice outside of the pandemic, PCI was associated with acceptable outcomes at 12 months of follow-up. Contemporary randomized trials that c…
View article: Coronary artery disease and outcomes following transcatheter aortic valve implantation
Coronary artery disease and outcomes following transcatheter aortic valve implantation Open
Background Aortic stenosis is a life-limiting condition for which transcatheter aortic valve implantation (TAVI) is an established therapy. Coronary artery disease (CAD) is frequently found in this patient group and optimal management in t…
View article: Contemporary outcomes of chronic total occlusion percutaneous coronary intervention in Europe: the ERCTO registry
Contemporary outcomes of chronic total occlusion percutaneous coronary intervention in Europe: the ERCTO registry Open
The adoption of different recanalisation techniques, operator experience and the use of specific devices have contributed to a high procedural success rate despite the high complexity of the lesions documented in the ERCTO.
View article: Saphenous Vein Graft Failure: Current Challenges and a Review of the Contemporary Percutaneous Options for Management
Saphenous Vein Graft Failure: Current Challenges and a Review of the Contemporary Percutaneous Options for Management Open
The use of saphenous vein grafts (SVGs) in the surgical management of obstructive coronary artery disease remains high despite a growing understanding of their limitations in longevity. In contemporary practice, approximately 95% of patien…
View article: The everolimus eluting Synergy Megatron<sup>TM</sup>drug‐eluting stent platform: Early outcomes from the European Synergy Megatron<sup>TM</sup>Implanters' Registry
The everolimus eluting Synergy Megatron<sup>TM</sup>drug‐eluting stent platform: Early outcomes from the European Synergy Megatron<sup>TM</sup>Implanters' Registry Open
Background The Synergy Megatron TM is an everolimus‐drug eluting stent that may offer advantages in the treatment of aorto‐ostial disease and large proximal vessels. Aims To report the short‐ to medium‐term clinical outcomes from the Europ…
View article: Viability and Outcomes With Revascularization or Medical Therapy in Ischemic Ventricular Dysfunction
Viability and Outcomes With Revascularization or Medical Therapy in Ischemic Ventricular Dysfunction Open
Importance In the Revascularization for Ischemic Ventricular Dysfunction (REVIVED-BCIS2) trial, percutaneous coronary intervention (PCI) did not improve outcomes for patients with ischemic left ventricular dysfunction. Whether myocardial v…
View article: Wire‐based antegrade dissection re‐entry technique for coronary chronic total occlusions percutaneous revascularization: Experience from the ERCTO Registry
Wire‐based antegrade dissection re‐entry technique for coronary chronic total occlusions percutaneous revascularization: Experience from the ERCTO Registry Open
Background The recent development and widespread adoption of antegrade dissection re‐entry (ADR) techniques have been underlined as one of the antegrade strategies in all worldwide CTO consensus documents. However, historical wire‐based AD…
View article: Arrhythmia and Death Following Percutaneous Revascularization in Ischemic Left Ventricular Dysfunction: Prespecified Analyses From the REVIVED-BCIS2 Trial
Arrhythmia and Death Following Percutaneous Revascularization in Ischemic Left Ventricular Dysfunction: Prespecified Analyses From the REVIVED-BCIS2 Trial Open
BACKGROUND: Ventricular arrhythmia is an important cause of mortality in patients with ischemic left ventricular dysfunction. Revascularization with coronary artery bypass graft or percutaneous coronary intervention is often recommended fo…
View article: The Direct and Indirect Effects of COVID-19 on Acute Coronary Syndromes
The Direct and Indirect Effects of COVID-19 on Acute Coronary Syndromes Open
View article: Early versus delayed complete revascularisation in patients presenting with ST-segment elevation myocardial infarction and multivessel disease: a systematic review and meta-analysis of randomised controlled trials
Early versus delayed complete revascularisation in patients presenting with ST-segment elevation myocardial infarction and multivessel disease: a systematic review and meta-analysis of randomised controlled trials Open
Background Several studies have demonstrated that complete revascularisation improves clinical outcomes in patients with ST-segment elevation myocardial infarction (STEMI) and multivessel coronary disease. However, the optimal timing of no…
View article: Timing of invasive strategy in non-ST-elevation acute coronary syndrome: a meta-analysis of randomized controlled trials
Timing of invasive strategy in non-ST-elevation acute coronary syndrome: a meta-analysis of randomized controlled trials Open
Aims The optimal timing of an invasive strategy (IS) in non-ST-elevation acute coronary syndrome (NSTE-ACS) is controversial. Recent randomized controlled trials (RCTs) and long-term follow-up data have yet to be included in a contemporary…
View article: The Direct and Indirect Effects of COVID-19 on Acute Coronary Syndromes
The Direct and Indirect Effects of COVID-19 on Acute Coronary Syndromes Open
View article: Cardiac magnetic resonance strain and mechanical dispersion assessment in patients with chronic total coronary artery occlusion
Cardiac magnetic resonance strain and mechanical dispersion assessment in patients with chronic total coronary artery occlusion Open
Background Chronic total occlusions (CTO) are a frequent angiographic finding. Viability of CTO-subtended myocardium is dependent on the presence of an adequate collateral circulation. At rest, collateral supply may be sufficient to avert …
View article: Cardiac rest and stress metabolism in type 2 diabetes (T2D): can the diabetic heart flex under stress?
Cardiac rest and stress metabolism in type 2 diabetes (T2D): can the diabetic heart flex under stress? Open
Background Efficient matching of energy supply to demand is essential for maintaining normal cardiac function. Altered cardiac metabolism may contribute to the development of cardiac dysfunction by impairing metabolic flexibility in type 2…
View article: 125 Cardiac metabolic flexibility and myocardial substrate utilisation in response to pharmacological stress in type 2 diabetes
125 Cardiac metabolic flexibility and myocardial substrate utilisation in response to pharmacological stress in type 2 diabetes Open
Background Efficient matching of energy supply to demand is essential for maintaining normal cardiac function. Altered cardiac metabolism may contribute to the development of cardiac dysfunction by impairing metabolic flexibility in type 2…
View article: Outcomes following <scp>PCI</scp> in <scp>CABG</scp> candidates during the <scp>COVID</scp>‐19 pandemic: The prospective multicentre <scp>UK‐ReVasc</scp> registry
Outcomes following <span>PCI</span> in <span>CABG</span> candidates during the <span>COVID</span>‐19 pandemic: The prospective multicentre <span>UK‐ReVasc</span> registry Open
Objectives To describe outcomes following percutaneous coronary intervention (PCI) in patients who would usually have undergone coronary artery bypass grafting (CABG). Background In the United Kingdom, cardiac surgery for coronary artery d…
View article: TCT CONNECT-226 In-Hospital Outcomes of CABG Candidates Undergoing PCI During the ICU Restricted COVID-19 Pandemic: The Multi-Center Prospective UK-REVASC Registry
TCT CONNECT-226 In-Hospital Outcomes of CABG Candidates Undergoing PCI During the ICU Restricted COVID-19 Pandemic: The Multi-Center Prospective UK-REVASC Registry Open
View article: P451Influence of diabetes mellitus on ischaemia burden and collateralization in chronic total coronary artery occlusion
P451Influence of diabetes mellitus on ischaemia burden and collateralization in chronic total coronary artery occlusion Open
Background: Coronary chronic total occlusions (CTO) are present in up to one third of patients with coronary artery disease referred for invasive coronary angiography.In CTO-subtended myocardial territories, the development of collateral c…