Andrew M. Dacks
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View article: Shaping of olfactory responses by taste in a new assay for operant learning in <i>Drosophila melanogaster</i>
Shaping of olfactory responses by taste in a new assay for operant learning in <i>Drosophila melanogaster</i> Open
Animals are driven to maximize food rewards and adjust their behavior to seek high-quality food and avoid low-quality options. This holds true for Drosophila melanogaster, which approaches food-associated odors and tastes while avoiding av…
View article: Individual olfactory channels shape distinct parameters of sleep architecture
Individual olfactory channels shape distinct parameters of sleep architecture Open
Across the animal kingdom, olfactory dysfunction and anosmia have been associated with disruptions in sleep. In the fruit fly Drosophila melanogaster , various studies have demonstrated that broadly inhibiting olfactory receptor neurons (O…
View article: Selective life-long suppression of an odor processing channel in response to critical period experience
Selective life-long suppression of an odor processing channel in response to critical period experience Open
Sensory circuits undergo experience-dependent plasticity during early-life critical periods, attuning the nervous system to levels of key environmental stimuli. During a critical period in the Drosophila olfactory system, we found that exp…
View article: Selective life-long suppression of an odor processing channel in response to critical period experience
Selective life-long suppression of an odor processing channel in response to critical period experience Open
Sensory circuits undergo experience-dependent plasticity during early-life critical periods, attuning the nervous system to levels of key environmental stimuli. During a critical period in the Drosophila olfactory system, we found that exp…
View article: MCA: A Multicellular analysis Calcium Imaging toolbox for ImageJ
MCA: A Multicellular analysis Calcium Imaging toolbox for ImageJ Open
Summary Functional imaging using genetically encoded indicators, such as GCaMP, has become a foundational tool for in vivo experiments and allows for the analysis of cellular dynamics, sensory processing, and cellular communication. Howeve…
View article: Connectivity of serotonin neurons reveals a constrained inhibitory subnetwork within the olfactory system
Connectivity of serotonin neurons reveals a constrained inhibitory subnetwork within the olfactory system Open
Inhibitory local interneurons (LNs) play an essential role in sensory processing by refining stimulus representations via a diverse collection of mechanisms. The morphological and physiological traits of individual LN types, as well as the…
View article: Selective life-long suppression of an odor processing channel in response to critical period experience
Selective life-long suppression of an odor processing channel in response to critical period experience Open
Sensory circuits undergo experience-dependent plasticity during early-life critical periods, attuning the nervous system to levels of key environmental stimuli. During a critical period in the Drosophila olfactory system, we found that exp…
View article: The Roles of Discrete Populations of Neurons Expressing Short Neuropeptide F in Sleep Induction in <scp><i>Drosophila melanogaster</i></scp>
The Roles of Discrete Populations of Neurons Expressing Short Neuropeptide F in Sleep Induction in <span><i>Drosophila melanogaster</i></span> Open
Sleep is of vital importance in our lives, yet we are far from understanding the neuronal networks that control the amount and timing of sleep. There is substantial conservation of known sleep‐regulating transmitters, allowing for studies …
View article: Serotonin acts through multiple cellular targets during an olfactory critical period
Serotonin acts through multiple cellular targets during an olfactory critical period Open
View article: Serotonin acts through multiple cellular targets during an olfactory critical period
Serotonin acts through multiple cellular targets during an olfactory critical period Open
Serotonin (5-HT) is known to modulate early development during critical periods when experience drives heightened levels of plasticity in neurons. Here, we take advantage of the genetically tractable olfactory system of Drosophila to inves…
View article: Organization of an ascending circuit that conveys flight motor state in Drosophila
Organization of an ascending circuit that conveys flight motor state in Drosophila Open
View article: Olfactory Critical Periods: How Odor Exposure Shapes the Developing Brain in Mice and Flies
Olfactory Critical Periods: How Odor Exposure Shapes the Developing Brain in Mice and Flies Open
Neural networks have an extensive ability to change in response to environmental stimuli. This flexibility peaks during restricted windows of time early in life called critical periods. The ubiquitous occurrence of this form of plasticity …
View article: Heterogeneous receptor expression underlies non-uniform peptidergic modulation of olfaction in Drosophila
Heterogeneous receptor expression underlies non-uniform peptidergic modulation of olfaction in Drosophila Open
Sensory systems are dynamically adjusted according to the animal’s ongoing needs by neuromodulators, such as neuropeptides. Neuropeptides are often widely-distributed throughout sensory networks, but it is unclear whether such neuropeptide…
View article: Heterogeneous Receptor Expression Underlies Non-uniform Peptidergic Modulation of Olfaction in Drosophila
Heterogeneous Receptor Expression Underlies Non-uniform Peptidergic Modulation of Olfaction in Drosophila Open
Original confocal scans for all light microscopy images in the main and supplementary figures of Sizemore et al., 2023. If you make use of this data, please cite: Heterogeneous Receptor Expression Underlies Non-uniform Pep…
View article: Heterogeneous Receptor Expression Underlies Non-uniform Peptidergic Modulation of Olfaction in Drosophila
Heterogeneous Receptor Expression Underlies Non-uniform Peptidergic Modulation of Olfaction in Drosophila Open
Original confocal scans for all light microscopy images in the main and supplementary figures of Sizemore et al., 2023. If you make use of this data, please cite: Heterogeneous Receptor Expression Underlies Non-uniform Pep…
View article: Stimulus-Specific Modulation is Enabled by Differential Serotonin Receptor Expression
Stimulus-Specific Modulation is Enabled by Differential Serotonin Receptor Expression Open
Neural networks must be able to flexibly process information under different conditions. To this end, networks frequently rely on uniform expression of modulatory receptors by distinct classes of neurons to fine tune the computations suppo…
View article: Organization of an Ascending Circuit that Conveys Flight Motor State
Organization of an Ascending Circuit that Conveys Flight Motor State Open
Summary Natural behaviors are a coordinated symphony of motor acts which drive self-induced or reafferent sensory activation. Single sensors only signal presence and magnitude of a sensory cue; they cannot disambiguate exafferent (external…
View article: Heterogeneous Receptor Expression Underlies Non-uniform Peptidergic Modulation of Olfaction in<i>Drosophila</i>
Heterogeneous Receptor Expression Underlies Non-uniform Peptidergic Modulation of Olfaction in<i>Drosophila</i> Open
Sensory systems are dynamically adjusted according to the animal’s ongoing needs by neuromodulators, such as neuropeptides. Although many neuropeptides are often widely-distributed throughout sensory networks, it is unclear whether such ne…
View article: Serotonergic modulation of visual neurons in Drosophila melanogaster
Serotonergic modulation of visual neurons in Drosophila melanogaster Open
Sensory systems rely on neuromodulators, such as serotonin, to provide flexibility for information processing as stimuli vary, such as light intensity throughout the day. Serotonergic neurons broadly innervate the optic ganglia of Drosophi…
View article: Circadian Clocks: Mosquitoes Master the Dark Side of the Room
Circadian Clocks: Mosquitoes Master the Dark Side of the Room Open
View article: The Wiring Logic of an Identified Serotonergic Neuron That Spans Sensory Networks
The Wiring Logic of an Identified Serotonergic Neuron That Spans Sensory Networks Open
Serotonergic neurons project widely throughout the brain to modulate diverse physiological and behavioral processes. However, a single-cell resolution understanding of the connectivity of serotonergic neurons is currently lacking. Using a …
View article: Serotonergic modulation across sensory modalities
Serotonergic modulation across sensory modalities Open
The serotonergic system has been widely studied across animal taxa and different functional networks. This modulatory system is therefore well positioned to compare the consequences of neuromodulation for sensory processing across species …
View article: The wiring logic of an identified serotonergic neuron that spans sensory networks
The wiring logic of an identified serotonergic neuron that spans sensory networks Open
Serotonergic neurons modulate diverse physiological and behavioral processes in a context-dependent manner, based on their complex connectivity. However, their connectivity has not been comprehensively explored at a single-cell resolution.…
View article: Local synaptic inputs support opposing, network-specific odor representations in a widely projecting modulatory neuron
Local synaptic inputs support opposing, network-specific odor representations in a widely projecting modulatory neuron Open
This is the data set for Zhang et al. 2019 "Local synaptic inputs support opposing, network-specific odor representations in a widely projecting modulatory neuron" published at eLife.
View article: Local synaptic inputs support opposing, network-specific odor representations in a widely projecting modulatory neuron
Local synaptic inputs support opposing, network-specific odor representations in a widely projecting modulatory neuron Open
This is the data set for Zhang et al. 2019 "Local synaptic inputs support opposing, network-specific odor representations in a widely projecting modulatory neuron" published at eLife.
View article: Local synaptic inputs support opposing, network-specific odor representations in a widely projecting modulatory neuron
Local synaptic inputs support opposing, network-specific odor representations in a widely projecting modulatory neuron Open
Serotonin plays different roles across networks within the same sensory modality. Previously, we used whole-cell electrophysiology in Drosophila to show that serotonergic neurons innervating the first olfactory relay are inhibited by odora…
View article: Author response: Local synaptic inputs support opposing, network-specific odor representations in a widely projecting modulatory neuron
Author response: Local synaptic inputs support opposing, network-specific odor representations in a widely projecting modulatory neuron Open
View article: Regulation of modulatory cell activity across olfactory structures in <i>Drosophila melanogaster</i>
Regulation of modulatory cell activity across olfactory structures in <i>Drosophila melanogaster</i> Open
All centralized nervous systems possess modulatory neurons that arborize broadly across multiple brain regions. Such modulatory systems are critical for proper sensory, motor, and cognitive processing. How single modulatory neurons integra…
View article: Systematic Analysis of Transmitter Coexpression Reveals Organizing Principles of Local Interneuron Heterogeneity
Systematic Analysis of Transmitter Coexpression Reveals Organizing Principles of Local Interneuron Heterogeneity Open
Broad neuronal classes are surprisingly heterogeneous across many parameters, and subclasses often exhibit partially overlapping traits including transmitter coexpression. However, the extent to which transmitter coexpression occurs in pre…
View article: Intrinsic and Extrinsic Neuromodulation of Olfactory Processing
Intrinsic and Extrinsic Neuromodulation of Olfactory Processing Open
Neuromodulation is a ubiquitous feature of neural systems, allowing flexible, context specific control over network dynamics. Neuromodulation was first described in invertebrate motor systems and early work established a basic dichotomy fo…