Andrew Lewis
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View article: Non-Invasive Wearable Technology to Predict Heart Failure Decompensation
Non-Invasive Wearable Technology to Predict Heart Failure Decompensation Open
Heart failure (HF) remains a leading cause of recurrent hospitalisations worldwide, largely driven by acute episodes of decompensation. Early identification of impending decompensation could enable timely intervention and potentially preve…
View article: Cardiac energetics in severe mitral regurgitation: relationship with eccentric hypertrophy, stroke volume, and effects of valve repair
Cardiac energetics in severe mitral regurgitation: relationship with eccentric hypertrophy, stroke volume, and effects of valve repair Open
Aims Understanding changes in ATP metabolism may lead to improved risk stratification in severe primary mitral regurgitation (MR). Here, we seek to compare the energetic phenotype of volume-overload pathological hypertrophy with athletic h…
View article: Obesity and heart failure: exploring the cardiometabolic axis
Obesity and heart failure: exploring the cardiometabolic axis Open
Obesity is one of the biggest risks to public health in both developed and developing countries, and yet incidence continues to skyrocket. Being the main risk factor for a large number of life-limiting conditions, obesity has the potential…
View article: Targeting immunometabolic pathways with AZD1656 alleviates inflammation and metabolic dysfunction in type 2 diabetic cardiomyopathy
Targeting immunometabolic pathways with AZD1656 alleviates inflammation and metabolic dysfunction in type 2 diabetic cardiomyopathy Open
Type 2 diabetes (T2D) precipitates diabetic cardiomyopathy (dbCM), a condition characterized by chronic inflammation, metabolic dysregulation and impaired cardiac performance. Here we show that the glucokinase activator AZD1656, originally…
View article: Metabolic flexibility and reverse remodelling of the failing human heart
Metabolic flexibility and reverse remodelling of the failing human heart Open
Background and Aims Cardiac resynchronization therapy (CRT) produces long-term reverse remodelling which requires greater adenosine triphosphate delivery to the contractile machinery. Whilst the heart retains some metabolic flexibility in …
View article: Exercise CMR and proteomic characterization of HFpEF across the spectrum of LV ejection fraction
Exercise CMR and proteomic characterization of HFpEF across the spectrum of LV ejection fraction Open
Background: Heterogeneity within heart failure with preserved ejection fraction (HFpEF) is poorly understood and hinders the development of new therapies for this condition. Despite comparable symptom burden, clinical trials suggest differ…
View article: Evaluation of an integrated variable flip angle protocol to estimate coil <scp>B<sub>1</sub></scp> for hyperpolarized <scp>MRI</scp>
Evaluation of an integrated variable flip angle protocol to estimate coil <span>B<sub>1</sub></span> for hyperpolarized <span>MRI</span> Open
Purpose The purpose of this work is to validate a simple and versatile integrated variable flip angle (VFA) method for mapping B 1 in hyperpolarized MRI, which can be used to correct signal variations due to coil inhomogeneity. Theory and …
View article: Factors that Influence Applicant Choice of In-Person versus Virtual Interview Format
Factors that Influence Applicant Choice of In-Person versus Virtual Interview Format Open
Most applicants prefer an IPI format. Influential factors differ between those who choose VI versus IPI. Recognizing factors that differentiate preference for IPI versus VI is essential to mitigating potential inequity in this process.
View article: Multi-modal characterisation of early-stage, subclinical cardiac deterioration in patients with type 2 diabetes
Multi-modal characterisation of early-stage, subclinical cardiac deterioration in patients with type 2 diabetes Open
Background Type 2 diabetes mellitus (T2DM) is a major risk factor for heart failure with preserved ejection fraction and cardiac arrhythmias. Precursors of these complications, such as diabetic cardiomyopathy, remain incompletely understoo…
View article: Hyperpolarized <sup>13</sup>C and <sup>31</sup>P MRS detects differences in cardiac energetics, metabolism, and function in obesity, and responses following treatment
Hyperpolarized <sup>13</sup>C and <sup>31</sup>P MRS detects differences in cardiac energetics, metabolism, and function in obesity, and responses following treatment Open
Obesity is associated with important changes in cardiac energetics and function, and an increased risk of adverse cardiovascular outcomes. Multi‐nuclear MRS and MRI techniques have the potential to provide a comprehensive non‐invasive asse…
View article: Multi-modal characterisation of cardiac function and electrophysiology in type 2 diabetes: a UK Biobank cross-sectional study
Multi-modal characterisation of cardiac function and electrophysiology in type 2 diabetes: a UK Biobank cross-sectional study Open
Background and Aim Type 2 diabetes mellitus (T2DM) is a major risk factor for heart failure, ischemic heart disease, and cardiac arrhythmias. Our goal is to examine the association of T2DM with ECG and cardiac imaging biomarkers, providing…
View article: The effect of sodium‐glucose co‐transporter 2 inhibitors on outcomes after cardiac resynchronization therapy
The effect of sodium‐glucose co‐transporter 2 inhibitors on outcomes after cardiac resynchronization therapy Open
Aims The trials upon which recommendations for the use of cardiac resynchronization therapy (CRT) in heart failure used optimal medical therapy (OMT) before sodium‐glucose co‐transporter 2 inhibitors (SGLT2i). Moreover, the SGLT2i heart fa…
View article: The effect of sodium‐glucose cotransporter‐2 inhibitors on inflammatory biomarkers: A meta‐analysis of randomized controlled trials
The effect of sodium‐glucose cotransporter‐2 inhibitors on inflammatory biomarkers: A meta‐analysis of randomized controlled trials Open
Aims To conduct a meta‐analysis of randomized controlled trials (RCTs) to assess the effect of sodium‐glucose cotransporter‐2 (SGLT2) inhibitors on inflammatory biomarkers. Methods Medline, Embase and the Cochrane Library were searched for…
View article: Characterization and Prognostic Implications of Respirophasic Variation in Invasive Hemodynamic Measurements at Rest and With Exercise
Characterization and Prognostic Implications of Respirophasic Variation in Invasive Hemodynamic Measurements at Rest and With Exercise Open
Pulmonary capillary wedge pressure (PCWP) is a key measure of left heart congestion used to establish or rule out the diagnosis of heart failure (HF). Diagnostic algorithms for HF with preserved ejection fraction (HFpEF) include or are val…
View article: The effect of bariatric surgery type on cardiac reverse remodelling
The effect of bariatric surgery type on cardiac reverse remodelling Open
Introduction Bariatric surgery has been shown to improve adverse cardiac remodelling associated with obesity. Three operations are commonly performed: Roux-en-Y Gastric Bypass (RYGB), Laparoscopic Sleeve Gastrectomy (LSG) and Laparoscopic …
View article: Investigating the cardiac manifestations of IgG4-related disease using cardiac magnetic resonance imaging
Investigating the cardiac manifestations of IgG4-related disease using cardiac magnetic resonance imaging Open
Introduction IgG4-related disease (IgG4-RD) is a relapsing-remitting immune-mediated condition that affects multiple organ systems. Case reports of suspected cardiovascular involvement in IgG4-RD have emerged though no study has systematic…