Explanipedia

Commercial or industrial use of mental health data for research: primer and best-practice guidelines from the DATAMIND patient/public Lived Experience Advisory Group Open

Linda A. Jones, C. R. Barber, Naomi Clements-Brod, Jan M. Davies, Marcos DelPozo‐Baños , et al. · 2025

BACKGROUND: Routinely collected health data, such as that held by the United Kingdom (UK) National Health Service/Health and Social Care (collectively "NHS"), has important research uses, but its appropriate use requires public trust and t…

Depression Detectives: A methodology for online co-created research Open

Sophia Collins, Christine Kupfer, Stephanie Organ, Melissa Lewins, Andrew M. McIntosh , et al. · 2025

Background: Incorporating lived experiences into research is claimed to enhance depth, relevance, real-world applicability and equity. However, data scientists have been slower to adopt this approach than other health fields. The "Depressi…

Transdiagnostic alterations in white matter microstructure associated with suicidal thoughts and behaviours in the ENIGMA Suicidal Thoughts and Behaviours consortium Open

Lejla Čolić, Zuriel Ceja, Maria R. Dauvermann, Luca M. Villa, Hannah S. Savage , et al. · 2025

Genetic Liabilities to Neuropsychiatric Conditions in Suicide Deaths With No Prior Suicidality Open

Hilary Coon, Andrey A. Shabalin, Eric T. Monson, Emily DiBlasi, Seonggyun Han , et al. · 2025

Importance Although suicide attempt is the most robust estimator of suicide death, few individuals who attempt it go on to die by suicide (<10%), and approximately 50% of suicide deaths occur in the absence of evidence of prior atte…

Clinical trials in depression: Integrated collection across EU and US registries Open

Kate Stewart, Louise Schindler, Robert Bevan, Samrina Rehman, Matthew H. Iveson , et al. · 2025

Depression affects millions worldwide with both pharmacological and psychological therapies widely applied, both with limited treatment success. Many clinical trials have been undertaken to test and compare treatments for depression. In co…

Depression Genetics in Africa (DepGenAfrica): protocol for the first large-scale case-control study of major depressive disorder among continental Africans Open

Adeniran Okewole, Jared Maina, Wisdom P. Nakanga, Vivien J. Chebii, Natalie Smyth , et al. · 2025

Background Major Depressive Disorder (MDD) is a disabling condition that arises from the interplay of genetic and environmental risk factors. Most genetic studies of depression to date have failed to include continental African populations…

Estimating disorder probability based on polygenic prediction using the BPC approach Open

Emil Uffelmann, Cathryn M. Lewis, Andrew M. McIntosh, Micheal C. O’Donovan, James Walters , et al. · 2025

Polygenic Scores (PGSs) summarize an individual’s genetic propensity for a given trait. Bayesian methods, which improve the prediction accuracy of PGSs, are not well-calibrated for binary disorder traits in ascertained samples. This is a p…

Genome-wide association study of adolescent-onset depression Open

P Grimes, Brittany L. Mitchell, Katherine Thompson, Qiudong Deng, Xueyi Shen , et al. · 2025

Adolescent depression is a heritable psychiatric condition with rising global prevalence and severe long-term outcomes, yet its biological underpinnings remain poorly understood. We conducted the first genome-wide association study of adol…

Combined family history and polygenic score prediction of major depressive disorder Open

Rujia Wang, Helena L. Davies, Sang Hyuck Lee, Johan Zvrskovec, Christopher Hübel , et al. · 2025

Importance Major depressive disorder (MDD) is a complex psychiatric disorder influenced by genetic, social, and environmental factors. Family history, genome-wide polygenic scores, and childhood trauma are key predictors of MDD onset with …

Cohort profile: Cell-omics Resource of the Australian Genetics of Depression Study (AGDS:Cell-o) Open

Brittany L. Mitchell, Deborah Gilroy, Leanne Wallace, Jacqueline Kiewa, Richard Parker , et al. · 2025

Purpose Major depressive disorder (MDD) is recognised to be phenotypically heterogeneous, yet subtyping based on clinical features has remained elusive. Here, we investigate heterogeneity by antidepressant-usage according to prescription r…

A methylome-wide association study of major depression with out-of-sample case–control classification and trans-ancestry comparison Open

Xueyi Shen, Miruna C. Barbu, Doretta Caramaschi, Ryan Arathimos, Darina Czamara , et al. · 2025

Major depression (MD) is a leading cause of global disease burden, and both experimental and population-based studies suggest that differences in DNA methylation may be associated with the condition. However, previous DNA methylation studi…

Association between polygenic risk for Major Depression and brain structure in a mega-analysis of 50,975 participants across 11 studies Open

Xueyi Shen, Yara J. Toenders, Laura K. M. Han, Antoine Weihs, Nina Alexander , et al. · 2025

Major Depression (MD) is a prevalent, disabling and life-limiting condition. The neurobiological associations of genetic risk for MD remain under-explored in large samples, with no comprehensive mega-analysis conducted to date. Our study a…

Genome-wide analysis of 439 mass spectrometry-based proteomic profiles in a population of 15,035 Scottish individuals Open

Anne Richmond, Janet Robertson, Hannah M. Smith, Robert F. Hillary, Aleksej Zelezniak , et al. · 2025

Understanding the genetic architecture of the circulating proteome can help determine if a protein is causally linked to disease. Previous large-scale genome-wide association studies (GWAS) of proteins have mostly been conducted to pre-def…

Epigenetic and Structural Brain Aging and Their Associations With Major Depressive Disorder Open

Eileen Y. Xu, Claire Green, Daniel L. McCartney, Laura K. M. Han, Kathryn L. Evans , et al. · 2025

Measurement characteristics and genome-wide correlates of lifetime brain atrophy estimated from a single MRI Open

Anna E. Fürtjes, Isabelle F. Foote, Charley Xia, Gail Davies, Joanna E. Moodie , et al. · 2025

Effectiveness and Costs of Participant Recruitment Strategies to a Web-Based Population Cohort: Observational Study Open

Hannah Milbourn, Archie Campbell, F. Landon Clark, Elly Darrah, Robin Flaig , et al. · 2025

Background Recruitment to population-based health studies remains challenging, with difficulties meeting target participant numbers, biosample returns, and achieving a representative sample. Few studies provide evaluations of traditional a…

Neural correlates of adverse childhood experiences, depression and chronic pain in the reward system Open

Georgia Antoniou, Blair H. Smith, Liana Romaniuk, Heather C. Whalley, Andrew M. McIntosh , et al. · 2025

Adverse childhood experiences (ACEs) are common, altering behaviour and stress reactivity, with persistent structural and functional brain changes. ACEs are associated with a greater risk of physical and mental health morbidities, includin…

Genome-wide insights into generalised anxiety using a dimensional symptom severity approach Open

Megan Skelton, Brittany L. Mitchell, Elham Assary, Danyang Li, Geneviève Morneau‐Vaillancourt , et al. · 2025

We performed a genome-wide association meta-analysis of generalised anxiety symptom severity in 696,563 individuals of European ancestry from 14 cohorts. We identified 82 independent genome-wide significant variants within 76 loci, 41 of w…

The Psychiatric Genomics Consortium: Discoveries and Directions Open

Arpana Agrawal, Cynthia M. Bulik, Dawit Abebe, Ole A. Andreassen, Elizabeth G. Atkinson , et al. · 2025

The Psychiatric Genomics Consortium (PGC) has fueled discoveries of common and rare genetic variation contributing to liability to many psychiatric and neurodevelopmental conditions. This narrative review reflects on major findings from th…

The Psychiatric Genomics Consortium: Discoveries and Directions Open

Arpana Agrawal, Cynthia M. Bulik, Dawit Abebe, Ole A. Andreassen, Elizabeth G. Atkinson , et al. · 2025

The Psychiatric Genomics Consortium (PGC) has fueled discoveries of common and rare genetic variation contributing to liability to many psychiatric and neurodevelopmental conditions. This narrative review reflects on major findings from th…

Fine-mapping genomic loci refines bipolar disorder risk genes Open

Maria Koromina, Ashvin Ravi, Georgia Panagiotaropoulou, Brian M. Schilder, Jack Humphrey , et al. · 2025

Bipolar disorder is a heritable mental illness with complex etiology. While the largest published genome-wide association study identified 64 bipolar disorder risk loci, the causal SNPs and genes within these loci remain unknown. We applie…

The role of the university in making the built environment more accessible and inclusive for people with disability: A case study from New Zealand Open

Claire L Flemmer, R.L.C. Flemmer, Andrew M. McIntosh, Alastair van Heerden, Mikael Boulic , et al. · 2025

The need to reduce inequality for people with disabilities is a strong theme in the United Nations Sustainable Development Goals. Cities and communities should be inclusive, but the Built Environment has many buildings and spaces with prob…

Impact of lifestyle in chronic pain and depression: a propensity score analysis in UK biobank Open

H. W. Casey, Helen R. Wright, Josiah King, Mark J. Adams, Andrew M. McIntosh , et al. · 2025

Background Chronic pain and depression are prevalent global health burdens that frequently co-occur, leading to worse outcomes than either condition alone. Current treatments are frequently inadequate, particularly for comorbid chronic pa…

Genome-wide meta-analysis identifies genetic risk factors and implicates multiple body systems in panic attacks and disorder Open

Brittany L. Mitchell, Megan Skelton, Rujia Wang, Abigail ter Kuile, Alan E Murphy , et al. · 2025

Introductory paragraph Panic attacks, sudden episodes of intense fear accompanied by physical and psychological symptoms, affect approximately 23% of the population 1,2 . Panic disorder, diagnosed in 2– 4% 3 , involves recurrent attacks fo…

Data Resource Profile: Whole-Blood DNA Methylation Resource in Generation Scotland (MeGS) Open

Rosie M. Walker, Daniel L. McCartney, Kevin Carr, M. Barber, Xueyi Shen , et al. · 2025

Software Application Profile: TIDAL—Tool to Implement Developmental Analysis of Longitudinal data Open

Alex S. F. Kwong, Amelia Edmondson-Stait, Eileen Y. Xu, Ellen J. Thompson, Randall M. Parker , et al. · 2025

Genetic overlap between functional impairment and depression and anxiety symptom severity: Evidence from the GLAD Study Open

Megan Skelton, Jessica Mundy, Abigail ter Kuile, Brett N. Adey, Chérie Armour , et al. · 2025

Background Functional impairment in daily activities, such as work and socialising, is part of the diagnostic criteria for major depressive disorder (MDD) and most anxiety disorders. Despite evidence that symptom severity and functional im…

Stress, Depressive Symptoms, and Physical Strength Impact Brain Perivascular Spaces: A Cohort Study with Insights from First-Degree Relatives Open

Maria Valdés Hernández, Alexandra Morozova, Roberto Duarte Coello, Heather C. Whalley, Andrew M. McIntosh , et al. · 2025

Stress, depressive symptoms, cardiovascular health, and physical strength are well-recognised factors that contribute to microcirculatory changes in the brain. However, there is limited understanding of their impact on perivascular waste c…

Genetic overlap between functional impairment and depression and anxiety symptom severity: Evidence from the GLAD Study Open

Megan Skelton, Jessica Mundy, Abigail ter Kuile, Brett N. Adey, Chérie Armour , et al. · 2025

Background Functional impairment in daily activities, such as work and socialising, is part of the diagnostic criteria for major depressive disorder (MDD) and most anxiety disorders. Despite evidence that symptom severity and functional im…

The UK Biobank mental health enhancement 2022: Methods and results Open

Katrina A. S. Davis, Jonathan R. I. Coleman, Mark J. Adams, Gerome Breen, Na Cai , et al. · 2025

Background This paper introduces the UK Biobank (UKB) second mental health questionnaire (MHQ2), describes its design, the respondents and some notable findings. UKB is a large cohort study with over 500,000 volunteer participants aged 40–…

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