Andrew Tonkin
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View article: Cognitive trajectories and incident atrial fibrillation in the ASPREE cohort
Cognitive trajectories and incident atrial fibrillation in the ASPREE cohort Open
Background Atrial fibrillation (AF) is associated with aging and increased risk of stroke and dementia. We examined the association between incident AF and cognitive trajectories in older adults using longitudinal data from the ASPirin in …
View article: Aspirin, cardiovascular events, and major bleeding in older adults: extended follow-up of the ASPREE trial
Aspirin, cardiovascular events, and major bleeding in older adults: extended follow-up of the ASPREE trial Open
Background and Aims Guidelines recommend against routine initiation of low-dose aspirin in older adults for primary prevention of atherosclerotic cardiovascular disease events. This study aimed to estimate long-term and post-trial effects …
View article: Social determinants of health clusters and risk of cardiovascular disease among community-dwelling older men and women: A clustering and causal machine learning approach
Social determinants of health clusters and risk of cardiovascular disease among community-dwelling older men and women: A clustering and causal machine learning approach Open
The study highlights the interconnectedness of SDoH and their greater impact on women's CVD risk compared to men.
View article: STAREE-HEART: A randomized placebo-controlled trial of atorvastatin effects on a marker of cardiac aging in older individuals without prior cardiovascular disease events: Protocol and baseline description of participants
STAREE-HEART: A randomized placebo-controlled trial of atorvastatin effects on a marker of cardiac aging in older individuals without prior cardiovascular disease events: Protocol and baseline description of participants Open
clinicaltrials.gov. Unique identifier: NCT04536870.
View article: Incidence of major health events across metropolitan and regional areas: A 10+ year prospective study of 16,697 older Australians
Incidence of major health events across metropolitan and regional areas: A 10+ year prospective study of 16,697 older Australians Open
Objective To examine the prevalence of health risk factors by rurality status and the association of rurality and incidence of disability‐free survival (DFS), its components (death, dementia and physical disability), cardiovascular disease…
View article: Association of albuminuria with incident atrial fibrillation in healthy older adults
Association of albuminuria with incident atrial fibrillation in healthy older adults Open
Background Development of atrial fibrillation (AF) portends an increased risk of adverse cardiovascular outcomes. Relatively little is known about the longitudinal association between urine albumin excretion and the development of AF, part…
View article: Statin effects on the lipidome: Predicting statin usage and implications for cardiovascular risk prediction
Statin effects on the lipidome: Predicting statin usage and implications for cardiovascular risk prediction Open
Statin therapy is a highly successful and cost-effective strategy for the prevention and treatment of cardiovascular diseases (CVD). Adjusting for statin usage is crucial when exploring the association of the lipidome with CVD to avoid err…
View article: Effects of Combining Coronary Calcium Score With Treatment on Plaque Progression in Familial Coronary Artery Disease
Effects of Combining Coronary Calcium Score With Treatment on Plaque Progression in Familial Coronary Artery Disease Open
Importance Coronary artery calcium (CAC) scoring provides prognostic information, especially in patients at intermediate risk for coronary artery disease (CAD). However, the benefit of combining CAC score with a primary prevention strategy…
View article: Association of Year-to-Year Lipid Variability With Risk of Cognitive Decline and Dementia in Community-Dwelling Older Adults
Association of Year-to-Year Lipid Variability With Risk of Cognitive Decline and Dementia in Community-Dwelling Older Adults Open
Tracking variability of TC and LDL-c may serve as a novel biomarker of incident dementia and cognitive decline in older adults.
View article: Baseline Characteristics of Participants in STAREE: A Randomized Trial for Primary Prevention of Cardiovascular Disease Events and Prolongation of Disability‐Free Survival in Older People
Baseline Characteristics of Participants in STAREE: A Randomized Trial for Primary Prevention of Cardiovascular Disease Events and Prolongation of Disability‐Free Survival in Older People Open
Background The risk–benefit balance of statin use in healthy older people is uncertain. We describe the baseline characteristics of the STAREE (Statins in Reducing Events in the Elderly) trial, which is a randomized, double‐blind, placebo‐…
View article: Independence of Lipoprotein(a) and Low-Density Lipoprotein Cholesterol–Mediated Cardiovascular Risk: A Participant-Level Meta-Analysis
Independence of Lipoprotein(a) and Low-Density Lipoprotein Cholesterol–Mediated Cardiovascular Risk: A Participant-Level Meta-Analysis Open
BACKGROUND: Low-density lipoprotein cholesterol (LDL-C) and lipoprotein(a) (Lp[a]) levels are independently associated with atherosclerotic cardiovascular disease (ASCVD). However, the relationship between Lp(a) level, LDL-C level, and ASC…
View article: Plasma Protein Biomarkers and Long‐Term Cardiovascular Mortality Risk in Patients With Chronic Coronary Heart Disease
Plasma Protein Biomarkers and Long‐Term Cardiovascular Mortality Risk in Patients With Chronic Coronary Heart Disease Open
Background Protein biomarkers that reflect different pathophysiological pathways have been associated with the risk of adverse cardiovascular events. However, it is uncertain whether these associations are sustained with increasing years a…
View article: Cardiovascular disease and stroke following cancer and cancer treatment in older adults
Cardiovascular disease and stroke following cancer and cancer treatment in older adults Open
Background Cancer survivors can be at risk of cardiovascular disease (CVD) because of either their malignancy or its treatment. Although studies linking cancer and CVD exist, few examine risk in older adults, the impact of cancer treatment…
View article: The impact of incident stroke on cognitive trajectories in later life
The impact of incident stroke on cognitive trajectories in later life Open
Background Cognitive impairment is common after stroke, and a large proportion of stroke patients will develop dementia. However, there have been few large prospective studies which have assessed cognition both prior to and after stroke. T…
View article: Prognostic Value of Cardiovascular Biomarkers in the Population
Prognostic Value of Cardiovascular Biomarkers in the Population Open
Importance Identification of individuals at high risk for atherosclerotic cardiovascular disease within the population is important to inform primary prevention strategies. Objective To evaluate the prognostic value of routinely available …
View article: Testosterone and the risk of incident atrial fibrillation in older men: further analysis of the ASPREE study
Testosterone and the risk of incident atrial fibrillation in older men: further analysis of the ASPREE study Open
National Institute on Aging and National Cancer Institute at the National Institutes of Health; Australian Government (NHMRC, CSIRO); Monash University; and AlfredHealth.
View article: The ASPREE Healthy Ageing Biobank: Methodology and participant characteristics
The ASPREE Healthy Ageing Biobank: Methodology and participant characteristics Open
ASPirin in Reducing Events in the Elderly (ASPREE), a placebo-controlled prevention trial of low dose aspirin, provided the opportunity to establish a biospecimen biobank from initially healthy persons aged 70+ years for future research. T…
View article: Higher testosterone is associated with higher HDL-cholesterol and lower triglyceride concentrations in older women: an observational study
Higher testosterone is associated with higher HDL-cholesterol and lower triglyceride concentrations in older women: an observational study Open
In older women, higher endogenous testosterone concentrations are significantly associated with higher HDL-C and lower TG, indicating a less atherogenic profile. These findings suggest a neutral, or potentially protective, cardiovascular d…
View article: Occupational characteristics and disability-free survival after retirement age: an exploratory analysis from the ASPREE study
Occupational characteristics and disability-free survival after retirement age: an exploratory analysis from the ASPREE study Open
Background Certain occupational characteristics have been linked with poor health and reduced longevity. However, the association between occupational characteristics and survival free of disability in a post-retirement age group has not b…
View article: Low-Density-Lipoprotein Cholesterol and Mortality Outcomes Among Healthy Older Adults: A Post Hoc Analysis of ASPREE Trial
Low-Density-Lipoprotein Cholesterol and Mortality Outcomes Among Healthy Older Adults: A Post Hoc Analysis of ASPREE Trial Open
Background The prognostic implication of cholesterol levels in older adults remains uncertain. This study aimed to examine the relationship between low-density-lipoprotein cholesterol (LDL-c) and mortality outcomes in older individuals. Me…
View article: CARDIOVASCULAR DISEASE RISK SCORES AND INCIDENT DEMENTIA AND COGNITIVE DECLINE IN OLDER MEN AND WOMEN
CARDIOVASCULAR DISEASE RISK SCORES AND INCIDENT DEMENTIA AND COGNITIVE DECLINE IN OLDER MEN AND WOMEN Open
Background Risk factors for cardiovascular disease (CVD) also increase the risk of dementia. However, whether CVD risk scores are associated with dementia risk in older adults remains unclear. The aim of this study was to determine whether…
View article: Cardiovascular Disease Risk Scores and Risk of Cognitive Decline and Dementia in Older Men and Women
Cardiovascular Disease Risk Scores and Risk of Cognitive Decline and Dementia in Older Men and Women Open
Background Risk factors for cardiovascular disease (CVD) also increase the risk of dementia. However, whether commonly used CVD risk scores are associated with dementia in older adults who do not have a history of CVD remains unclear. The …