Andrew McEwan
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View article: Exploring the roles of conserved context‐dependent cis‐regulatory elements (<scp>cdCREs</scp>) in multicellularity, human health and disease
Exploring the roles of conserved context‐dependent cis‐regulatory elements (<span>cdCREs</span>) in multicellularity, human health and disease Open
Human development and health depend on the precise expression of relevant genes in specific cells, at precise times and in response to appropriate stimuli. This is known as context‐dependent gene regulation and relies on the activities of …
View article: Manual recovery and collection of <i>Pinus patula</i> biomass after two clearfell harvesting systems
Manual recovery and collection of <i>Pinus patula</i> biomass after two clearfell harvesting systems Open
View article: An ancient polymorphic regulatory region within the BDNF gene associated with obesity modulates anxiety-like behaviour in mice and humans
An ancient polymorphic regulatory region within the BDNF gene associated with obesity modulates anxiety-like behaviour in mice and humans Open
View article: An ancient polymorphic regulatory region within the BDNF gene associated with obesity modulates anxiety-like behaviour in mice and humans
An ancient polymorphic regulatory region within the BDNF gene associated with obesity modulates anxiety-like behaviour in mice and humans Open
Obesity and anxiety are morbidities notable for their increased impact on society during the recent COVID-19 pandemic. Understanding the mechanisms governing susceptibility to these conditions will increase quality of life and our resilien…
View article: Context-dependant enhancers as a reservoir of functional polymorphisms and epigenetic markers linked to alcohol use disorders and comorbidities
Context-dependant enhancers as a reservoir of functional polymorphisms and epigenetic markers linked to alcohol use disorders and comorbidities Open
View article: An ancient polymorphic regulatory region within the BDNF gene associated with obesity modulates anxiety-like behaviour in mice and humans
An ancient polymorphic regulatory region within the BDNF gene associated with obesity modulates anxiety-like behaviour in mice and humans Open
Obesity and anxiety are morbidities notable for their increased impact on society during the recent COVID-19 pandemic. Understanding the mechanisms governing susceptibility to these conditions will increase quality of life and our resilien…
View article: The anxiety and ethanol intake controlling GAL5.1 enhancer is epigenetically modulated by, and controls preference for, high-fat diet
The anxiety and ethanol intake controlling GAL5.1 enhancer is epigenetically modulated by, and controls preference for, high-fat diet Open
View article: Perspective: Quality Versus Quantity; Is It Important to Assess the Role of Enhancers in Complex Disease from an In Vivo Perspective?
Perspective: Quality Versus Quantity; Is It Important to Assess the Role of Enhancers in Complex Disease from an In Vivo Perspective? Open
Sequencing of the human genome has permitted the development of genome-wide association studies (GWAS) to analyze the genetics of a number of complex disorders such as depression, anxiety and substance abuse. Thanks to their ability to ana…
View article: The anxiety and ethanol intake controlling GAL5.1 enhancer is epigenetically modulated by, and controls preference for, high fat diet
The anxiety and ethanol intake controlling GAL5.1 enhancer is epigenetically modulated by, and controls preference for, high fat diet Open
Excess maternal fat intake and obesity increase offspring susceptibility to conditions such as chronic anxiety and substance abuse. We hypothesised that these susceptibilities are established through environmentally modulated DNA-methylati…
View article: CRISPR disruption and UK Biobank analysis of a highly conserved polymorphic enhancer suggests a role in male anxiety and ethanol intake
CRISPR disruption and UK Biobank analysis of a highly conserved polymorphic enhancer suggests a role in male anxiety and ethanol intake Open
View article: Manipulating Chain Type and Flail Drum Speed for Better Fibre Recovery in Chain-Flail Delimber-Debarker-Chipper Operations
Manipulating Chain Type and Flail Drum Speed for Better Fibre Recovery in Chain-Flail Delimber-Debarker-Chipper Operations Open
A chain-flail delimber-debarker-chipper (CFDDC) was adapted for treating smaller trees than normal by replacing the standard flails with lighter ones, and by reducing flail drum rotation speed. The machine produced 16 full containers (24 t…
View article: Disease‐associated polymorphisms within the conserved ECR1 enhancer differentially regulate the tissue‐specific activity of the cannabinoid‐1 receptor gene promoter; implications for cannabinoid pharmacogenetics
Disease‐associated polymorphisms within the conserved ECR1 enhancer differentially regulate the tissue‐specific activity of the cannabinoid‐1 receptor gene promoter; implications for cannabinoid pharmacogenetics Open
Cannabinoid receptor-1 (CB1) represents a potential drug target against conditions that include obesity and substance abuse. However, drug trials targeting CB1 (encoded by the CNR1 gene) have been compromised by differences in patient resp…
View article: Past, present and future of industrial plantation forestry and implication on future timber harvesting technology
Past, present and future of industrial plantation forestry and implication on future timber harvesting technology Open
Plantation forests are established, and expanding,
\nto satisfy increasing global demand for timber products.
\nShifting societal values, such as safety, productivity,
\nenvironmental, quality and social are influencing the
\nplantation fo…
View article: Disruption of an enhancer associated with addictive behaviour within the cannabinoid receptor-1 gene suggests a possible role in alcohol intake, cannabinoid response and anxiety-related behaviour
Disruption of an enhancer associated with addictive behaviour within the cannabinoid receptor-1 gene suggests a possible role in alcohol intake, cannabinoid response and anxiety-related behaviour Open
View article: Genetic, epigenetic and pharmacological influences modulating tissue specific regulation of the cannabinoid receptor-1 gene (CB<sub>1</sub>); implications for cannabinoid pharmacogenetics
Genetic, epigenetic and pharmacological influences modulating tissue specific regulation of the cannabinoid receptor-1 gene (CB<sub>1</sub>); implications for cannabinoid pharmacogenetics Open
Cannabinoid receptor-1 (CB 1 ) represents a potential drug target against conditions that include obesity and substance abuse. However, drug trials targeting CB 1 (encoded by the CNR1 gene) have been compromised by differences in patient r…
View article: Efficiency of Different Machine Layouts for Chain Flail Delimbing, Debarking and Chipping
Efficiency of Different Machine Layouts for Chain Flail Delimbing, Debarking and Chipping Open
Based on data collected from seven commercial harvesting operations in Western Australia, the study developed a productivity model for chain flail delimber–debarker–chippers (CFDDCs) used in blue gum (Eucalyptus globulus Labill.) plantatio…
View article: Excerpt from their in-progress collaborative manuscript Nature Building
Excerpt from their in-progress collaborative manuscript Nature Building Open
View article: A Robust Productivity Model for Grapple Yarding in Fast-Growing Tree Plantations
A Robust Productivity Model for Grapple Yarding in Fast-Growing Tree Plantations Open
New techniques have recently appeared that can extend the advantages of grapple yarding to fast-growing plantations. The most promising technique consists of an excavator-base un-guyed yarder equipped with new radio-controlled grapple carr…
View article: The effect of coppice management on stump volume recovery in mechanized operations
The effect of coppice management on stump volume recovery in mechanized operations Open
View article: A Blind Test of Computational Technique for Predicting the Likelihood of Peptide Sequences to Cyclize
A Blind Test of Computational Technique for Predicting the Likelihood of Peptide Sequences to Cyclize Open
An in silico computational technique for predicting peptide sequences that can be cyclized by cyanobactin macrocyclases, e.g., PatGmac, is reported. We demonstrate that the propensity for PatGmac-mediated cyclization …
View article: Factors affecting the productivity and work quality of chain flail delimbing and debarking
Factors affecting the productivity and work quality of chain flail delimbing and debarking Open
Chain flail delimbing and debarking may improve value recovery from small tree harvests,
\nwithout renouncing the benefits of multi-tree processing. The technology is mature and capable
\nof excellent performance, which has been documented…
View article: Accurate quantification of modified cyclic peptides without the need for authentic standards
Accurate quantification of modified cyclic peptides without the need for authentic standards Open
View article: Isolation and anti-HIV-1 integrase activity of lentzeosides A–F from extremotolerant lentzea sp. H45, a strain isolated from a high-altitude Atacama Desert soil
Isolation and anti-HIV-1 integrase activity of lentzeosides A–F from extremotolerant lentzea sp. H45, a strain isolated from a high-altitude Atacama Desert soil Open
View article: The effects of number of stems per stool on cutting productivity in coppiced <i>Eucalyptus</i> plantations
The effects of number of stems per stool on cutting productivity in coppiced <i>Eucalyptus</i> plantations Open
A time study was conducted to determine whether stem crowding had any impact on harvester productivity in stands. This represents an important element when trying to balance the advantages and disadvantages of coppice management in fast gr…
View article: Silviculture modernization in the South African forestry industry
Silviculture modernization in the South African forestry industry Open