Alireza Minagar
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View article: Aging disrupts spatiotemporal coordination in the cycling ovary
Aging disrupts spatiotemporal coordination in the cycling ovary Open
Summary Throughout the female reproductive lifespan, the ovary completes hundreds of cycles of follicle development, ovulation, and tissue regeneration 1–3 . These processes rely on the precise coordination of intricate multicellular inter…
View article: Correction to: The Human Gut Microbiota: A Dynamic Biologic Factory
Correction to: The Human Gut Microbiota: A Dynamic Biologic Factory Open
View article: Leptomeningeal Metastatic Prostate Cancer Imitating a Subdural Hematoma
Leptomeningeal Metastatic Prostate Cancer Imitating a Subdural Hematoma Open
Metastases to the dura and adjacent parenchyma occur in 1%-2% of patients with prostate cancer. Dural metastases manifest as subdural fluid collections and present as a chronic subdural hematoma. We present a patient with advanced prostate…
View article: Human placental mesenchymal stem cells improve stroke outcomes via extracellular vesicles-mediated preservation of cerebral blood flow
Human placental mesenchymal stem cells improve stroke outcomes via extracellular vesicles-mediated preservation of cerebral blood flow Open
View article: SC411 treatment can enhance survival in a mouse model of sickle cell disease
SC411 treatment can enhance survival in a mouse model of sickle cell disease Open
View article: The Relationship Between Obstructive Sleep Apnea and Ruptured Intracranial Aneurysms
The Relationship Between Obstructive Sleep Apnea and Ruptured Intracranial Aneurysms Open
View article: Protein Arginine Methyltransferases in Cardiovascular and Neuronal Function
Protein Arginine Methyltransferases in Cardiovascular and Neuronal Function Open
View article: Brain Endothelial Cells Release Apical and Basolateral Microparticles in Response to Inflammatory Cytokine Stimulation: Relevance to Neuroinflammatory Stress?
Brain Endothelial Cells Release Apical and Basolateral Microparticles in Response to Inflammatory Cytokine Stimulation: Relevance to Neuroinflammatory Stress? Open
Microparticles (MP) are regarded both as biomarkers and mediators of many forms of pathology, including neurovascular inflammation. Here, we characterized vectorial release of apical and basolateral MPs (AMPs and BMPs) from control and TNF…
View article: Bioinformatics Analyses Determined the Distinct CNS and Peripheral Surrogate Biomarker Candidates Between Two Mouse Models for Progressive Multiple Sclerosis
Bioinformatics Analyses Determined the Distinct CNS and Peripheral Surrogate Biomarker Candidates Between Two Mouse Models for Progressive Multiple Sclerosis Open
Previously, we have established two distinct progressive multiple sclerosis (MS) models by induction of experimental autoimmune encephalomyelitis (EAE) with myelin oligodendrocyte glycoprotein (MOG) in two mouse strains. A.SW mice develop …
View article: Theiler's Virus-Mediated Immunopathology in the CNS and Heart: Roles of Organ-Specific Cytokine and Lymphatic Responses
Theiler's Virus-Mediated Immunopathology in the CNS and Heart: Roles of Organ-Specific Cytokine and Lymphatic Responses Open
Theiler's murine encephalomyelitis virus (TMEV) induces different diseases in the central nervous system (CNS) and heart, depending on the mouse strains and time course, with cytokines playing key roles for viral clearance and immune-media…
View article: Multiple sclerosis pathogenesis: missing pieces of an old puzzle
Multiple sclerosis pathogenesis: missing pieces of an old puzzle Open
Traditionally, multiple sclerosis (MS) was considered to be a CD4 T cell-mediated CNS autoimmunity, compatible with experimental autoimmune encephalitis model, which can be characterized by focal lesions in the white matter. However, studi…
View article: Evaluation of the risk of cervical cancer in patients with Multiple Sclerosis treated with cytotoxic agents: A cohort study.
Evaluation of the risk of cervical cancer in patients with Multiple Sclerosis treated with cytotoxic agents: A cohort study. Open
Background: Since most patients with relapsing-remitting multiple sclerosis (RRMS) are women, the present study aimed to determine whether treatment of patients with MS by cytotoxic agents is associated with an increased risk of cer…
View article: Immunoregulation of Theiler’s virus-induced demyelinating disease by glatiramer acetate without suppression of antiviral immune responses
Immunoregulation of Theiler’s virus-induced demyelinating disease by glatiramer acetate without suppression of antiviral immune responses Open
View article: Utilizing the Modified T-Maze to Assess Functional Memory Outcomes After Cardiac Arrest
Utilizing the Modified T-Maze to Assess Functional Memory Outcomes After Cardiac Arrest Open
We have developed a simple, yet effective strategy to delineate working (short-term) memory via the T-maze in our global cerebral ischemia model (ACA).
View article: Cerebral ischemia and neuroregeneration
Cerebral ischemia and neuroregeneration Open
Cerebral ischemia is one of the leading causes of morbidity and mortality worldwide. Although stroke (a form of cerebral ischemia)-related costs are expected to reach 240.67 billion dollars by 2030, options for treatment against cerebral i…
View article: Variations in the cerebrospinal fluid proteome following traumatic brain injury and subarachnoid hemorrhage
Variations in the cerebrospinal fluid proteome following traumatic brain injury and subarachnoid hemorrhage Open
Consistent CSF elevation of CA-I and Prx-2 with concurrent depletion of Hp and Tf may represent a useful combination of biomarkers for the prediction of severity and prognosis following brain injury.
View article: 1018 RUPTURED CEREBRAL ANEURYSM AND OBSTRUCTIVE SLEEP APNEA: IS ANY LINK THERE?
1018 RUPTURED CEREBRAL ANEURYSM AND OBSTRUCTIVE SLEEP APNEA: IS ANY LINK THERE? Open
Obstructive sleep apnea (OSA) is associated with the progression of abdominal and thoracic aortic aneurysms. However, the role of OSA in the overall outcome of intracranial ruptured aneurysms (RIAs) has not yet been known. We have investig…
View article: Interruption of perivascular sympathetic nerves of cerebral arteries offers neuroprotection against ischemia
Interruption of perivascular sympathetic nerves of cerebral arteries offers neuroprotection against ischemia Open
Sympathetic nervous system activity is increased after cardiopulmonary arrest, resulting in vasoconstrictor release from the perivascular sympathetic nerves of cerebral arteries. However, the pathophysiological function of the perivascular…
View article: From trash to treasure: The untapped potential of endothelial microparticles in neurovascular diseases
From trash to treasure: The untapped potential of endothelial microparticles in neurovascular diseases Open
Discovered in 1947, microparticles (MP) represent a group of sub-micron cell-derived particles isolated by high speed centrifugation. Once regarded as cellular 'trash', in the past decade MP have gained tremendous attention in both basic s…
View article: Exploration of screening practices for obstructive sleep apnea in stroke medical community: A pilot study
Exploration of screening practices for obstructive sleep apnea in stroke medical community: A pilot study Open
Despite being an independent risk factor for stroke and TIA, majority of physicians in the pilot targeted cohort of medical professionals, who are involved in the management of stroke and TIA, do not screen these patients for SDB. Further …
View article: Erratum
Erratum Open
View article: Multiple Sclerosis Epidemiology in East Asia, South East Asia and South Asia: A Systematic Review
Multiple Sclerosis Epidemiology in East Asia, South East Asia and South Asia: A Systematic Review Open
Background: Multiple sclerosis (MS) is one of the most common chronic immune-mediated diseases of the human central nervous system and an important cause of non-traumatic neurologic disability among young population in severa…
View article: Neuromyelitis optica with linear enhancement of corpus callosum in brain magnetic resonance imaging with contrast: a case report
Neuromyelitis optica with linear enhancement of corpus callosum in brain magnetic resonance imaging with contrast: a case report Open
Linear enhancement of corpus callosum in magnetic resonance imaging with contrast agent could help in diagnosing neuromyelitis optica and differentiating it from other demyelinating disease, especially multiple sclerosis.
View article: Blood circulating microparticle species in relapsing–remitting and secondary progressive multiple sclerosis. A case–control, cross sectional study with conventional MRI and advanced iron content imaging outcomes
Blood circulating microparticle species in relapsing–remitting and secondary progressive multiple sclerosis. A case–control, cross sectional study with conventional MRI and advanced iron content imaging outcomes Open
View article: Heerfordt’s Syndrome : An interesting and under-recognised manifestation of sarcoidosis
Heerfordt’s Syndrome : An interesting and under-recognised manifestation of sarcoidosis Open
Sarcoidosis is a systemic granulomatous disease which principally involves the pulmonary and lymphatic systems. However, such a formal definition of sarcoidosis is simplistic since it can resemble many other diagnoses and may therefore hav…