Andrew Fagbemi
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View article: How can I help my pregnant patients quit using tobacco?
How can I help my pregnant patients quit using tobacco? Open
View article: Very Early-Onset IBD-Associated IL-18opathy Treated with an Anti-IL-18 Antibody
Very Early-Onset IBD-Associated IL-18opathy Treated with an Anti-IL-18 Antibody Open
Background/Objectives: The aetiology of inflammatory bowel disease (IBD), particularly if occurring early in childhood, is a diverse and patient-focused treatment that is required when standard therapy is ineffective. Materials and Methods…
View article: Reducing Metabolic Bone Disease Burden in Intestinal Failure Children on Home Parenteral Nutrition
Reducing Metabolic Bone Disease Burden in Intestinal Failure Children on Home Parenteral Nutrition Open
Objective: To determine the prevalence of secondary hyperparathyroidism in a cohort of pediatric patients receiving home parenteral nutrition. Methods: For a service review, a population‐based cohort of 37 pediatric intestinal failure pati…
View article: Efficacy and Safety of Teduglutide in Infants and Children With Short Bowel Syndrome Dependent on Parenteral Support
Efficacy and Safety of Teduglutide in Infants and Children With Short Bowel Syndrome Dependent on Parenteral Support Open
Objectives: Our objective was to evaluate the short‐ and long‐term safety and efficacy of teduglutide treatment in infants and children with short bowel syndrome with intestinal failure (SBS‐IF). Methods: Two open‐label phase 3 studies and…
View article: Non-GVHD enterocolitis following cord blood transplant
Non-GVHD enterocolitis following cord blood transplant Open
Enterocolitis is common after cord blood transplant (CBT) and a specific, non-GVHD entity with specific histopathologic features (“cord colitis”) has been described in certain cases in selected series. We conducted a blinded histopathologi…
View article: The Incidence and Characteristics of Venous Thromboembolisms in Paediatric-Onset Inflammatory Bowel Disease: A Prospective International Cohort Study Based on the PIBD-SETQuality Safety Registry
The Incidence and Characteristics of Venous Thromboembolisms in Paediatric-Onset Inflammatory Bowel Disease: A Prospective International Cohort Study Based on the PIBD-SETQuality Safety Registry Open
Background and Aims Guidelines regarding thromboprophylaxis for venous thromboembolisms [VTEs] in children with inflammatory bowel disease [IBD] are based on limited paediatric evidence. We aimed to prospectively assess the incidence of VT…
View article: P19 Efficacy of thiopurines in preventing infliximab antibody formation when used in dual therapy: experience from a single tertiary paediatric gastroenterology department
P19 Efficacy of thiopurines in preventing infliximab antibody formation when used in dual therapy: experience from a single tertiary paediatric gastroenterology department Open
Background and Aim There is evidence that shows addition of an immunomodulator (azathioprine or mercaptopurine) to Infliximab (IFX) therapy reduces antidrug antibodies, however, published evidence remains quite limited in paediatric popula…
View article: P09 Assessing vitamin E status in parental nutrition (PN) population in accordance to ESPGHAN guidance: Comparing serum vitamin E levels to vitamin E:cholesterol ratio
P09 Assessing vitamin E status in parental nutrition (PN) population in accordance to ESPGHAN guidance: Comparing serum vitamin E levels to vitamin E:cholesterol ratio Open
Introduction ESPGHAN guidance recommends measuring both serum vitamin E and its lipid ratio to accurately monitor vitamin E status amongst paediatric patients on PN. Alpha-tocopherol, the surrogate marker for vitamin E, is affected by lipi…
View article: G354(P) Experience of using anti-TNF infliximab in paediatric inflammatory bowel disease- single tertiary
G354(P) Experience of using anti-TNF infliximab in paediatric inflammatory bowel disease- single tertiary Open
Background The BSPGHAN and ESPGHAN 2018 standards on management of IBD advocate optimising the use of biological therapy by correlating infliximab drug and anti-body levels with clinical presentation, and subsequently altering treatment if…
View article: Neutrophil dysfunction triggers inflammatory bowel disease in G6PC3 deficiency
Neutrophil dysfunction triggers inflammatory bowel disease in G6PC3 deficiency Open
The glucose-6-phosphatase catalytic subunit 3 (G6PC3) encodes a ubiquitously expressed enzyme that regulates cytoplasmic glucose availability. Loss-of-function biallelic G6PC3 mutations cause severe congenital neutropenia and a diverse spe…
View article: Refractory very early-onset inflammatory bowel disease associated with cytosolic isoleucyl-tRNA synthetase deficiency: A case report
Refractory very early-onset inflammatory bowel disease associated with cytosolic isoleucyl-tRNA synthetase deficiency: A case report Open
This case report provides evidence that recessive mutations in cytosolic isoleucyl-tRNA synthetase are a novel monogenic cause of IBD, which should be considered, particularly in infants and children with a history of neonatal hepatitis an…
View article: REVIEW OF CELIAC DISEASE PRESENTATION IN A PEDIATRIC TERTIARY CENTRE
REVIEW OF CELIAC DISEASE PRESENTATION IN A PEDIATRIC TERTIARY CENTRE Open
BACKGROUND: Celiac disease is an immune-mediated disorder with a multiform presentation and therefore a challenging diagnosis. OBJECTIVE: Our purpose is to identify the epidemiological, clinical, laboratory and histologic characteristics o…
View article: ‘Holiday sickness’—reported exploratory outcome of over 500 United Kingdom holidaymakers with travellers’ diarrhoea
‘Holiday sickness’—reported exploratory outcome of over 500 United Kingdom holidaymakers with travellers’ diarrhoea Open
Very few patients provide a stool sample after experiencing holiday sickness abroad. Of those that do, only a small proportion have a positive stool sample indicative of a food poisoning microorganism. Around 6% of individuals were diagnos…
View article: Telephone Consultation as a Substitute for Routine Out-patient Face-to-face Consultation for Children With Inflammatory Bowel Disease: Randomised Controlled Trial and Economic Evaluation
Telephone Consultation as a Substitute for Routine Out-patient Face-to-face Consultation for Children With Inflammatory Bowel Disease: Randomised Controlled Trial and Economic Evaluation Open