Andrew O. Kadlec
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View article: Anatomical Considerations and Emerging Strategies for Reducing New Onset Conduction Disturbances in Percutaneous Structural Heart Disease Interventions
Anatomical Considerations and Emerging Strategies for Reducing New Onset Conduction Disturbances in Percutaneous Structural Heart Disease Interventions Open
View article: Peri-Device Leaks after Percutaneous Left Atrial Appendage Closure: Clinical Significance and Unmet Diagnostic Needs
Peri-Device Leaks after Percutaneous Left Atrial Appendage Closure: Clinical Significance and Unmet Diagnostic Needs Open
View article: Cefepime-induced Neurotoxicity: Five Cases Reported in a Single Institution
Cefepime-induced Neurotoxicity: Five Cases Reported in a Single Institution Open
View article: Lysophosphatidic acid acts on LPA<sub>1</sub>receptor to increase H<sub>2</sub>O<sub>2</sub>during flow‐induced dilation in human adipose arterioles
Lysophosphatidic acid acts on LPA<sub>1</sub>receptor to increase H<sub>2</sub>O<sub>2</sub>during flow‐induced dilation in human adipose arterioles Open
Background and Purpose NO produces arteriolar flow‐induced dilation (FID) in healthy subjects but is replaced by mitochondria‐derived hydrogen peroxide (mtH 2 O 2 ) in patients with coronary artery disease (CAD). Lysophosphatidic acid (LPA…
View article: Physiological Consequences of Coronary Arteriolar Dysfunction and Its Influence on Cardiovascular Disease
Physiological Consequences of Coronary Arteriolar Dysfunction and Its Influence on Cardiovascular Disease Open
To date, the major focus of diagnostic modalities and interventions to treat coronary artery disease has been the large epicardial vessels. Despite substantial data showing that microcirculatory dysfunction is a strong predictor of future …
View article: The Yin and Yang of endothelium-derived vasodilator factors
The Yin and Yang of endothelium-derived vasodilator factors Open
View article: Telomerase reverse transcriptase protects against angiotensin II-induced microvascular endothelial dysfunction
Telomerase reverse transcriptase protects against angiotensin II-induced microvascular endothelial dysfunction Open
A rise in reactive oxygen species (ROS) may contribute to cardiovascular disease by reducing nitric oxide (NO) levels, leading to loss of NO’s vasodilator and anti-inflammatory effects. Although primarily studied in larger conduit arteries…
View article: Microvascular Adaptations to Exercise: Protective Effect of PGC-1 Alpha
Microvascular Adaptations to Exercise: Protective Effect of PGC-1 Alpha Open
BACKGROUND Sedentary behavior and obesity are major risk factors for cardiovascular disease. Regular physical activity has independent protective effects on the cardiovascular system, but the mechanisms responsible remain elusive. Recent s…
View article: PGC-1α (Peroxisome Proliferator–Activated Receptor γ Coactivator 1-α) Overexpression in Coronary Artery Disease Recruits NO and Hydrogen Peroxide During Flow-Mediated Dilation and Protects Against Increased Intraluminal Pressure
PGC-1α (Peroxisome Proliferator–Activated Receptor γ Coactivator 1-α) Overexpression in Coronary Artery Disease Recruits NO and Hydrogen Peroxide During Flow-Mediated Dilation and Protects Against Increased Intraluminal Pressure Open
Blood flow through healthy human vessels releases NO to produce vasodilation, whereas in patients with coronary artery disease (CAD), the mediator of dilation transitions to mitochondria-derived hydrogen peroxide ( mt H 2 O 2 ). Excessive …
View article: Adapt or Perish
Adapt or Perish Open
View article: Hypertension during Weight Lifting Reduces Flow-Mediated Dilation in Nonathletes
Hypertension during Weight Lifting Reduces Flow-Mediated Dilation in Nonathletes Open
The purpose of this study was to determine whether increased intraluminal pressure is the damaging factor that reduces flow-mediated dilation (FMD) in young, healthy subjects after resistance exercise to maximal exertion.Attenuating the ri…
View article: Friend or foe? Telomerase as a pharmacological target in cancer and cardiovascular disease
Friend or foe? Telomerase as a pharmacological target in cancer and cardiovascular disease Open
View article: Role of PGC-1α in Vascular Regulation
Role of PGC-1α in Vascular Regulation Open
Mitochondrial dysfunction results in high levels of oxidative stress and mitochondrial damage, leading to disruption of endothelial homeostasis. Recent discoveries have clarified several pathways, whereby mitochondrial dysregulation contri…
View article: Mitochondrial signaling in the vascular endothelium: beyond reactive oxygen species
Mitochondrial signaling in the vascular endothelium: beyond reactive oxygen species Open