Explanipedia

Targeting ecto‐5′‐nucleotidase (CD73) and cAMP alleviates carotid body hyperactivity and reduces blood pressure in chronically hypoxic rats Open

Demitris Nathanael, Andrew M. Coney, Dhaifallah Alotaibi, Andrew P. Holmes · 2025

Chronic hypoxia (CH) is a key feature of chronic obstructive pulmonary disease (COPD), and carotid body hyperactivity is a major contributor to the cardiovascular pathology seen in these patients. CD73, an ecto‐5′‐nucleotidase that convert…

Early Atrial Remodeling Drives Arrhythmia in Fabry Disease Open

Ashwin Roy, Christopher O’Shea, Albert Dasí, Leena Patel, Max J. Cumberland , et al. · 2025

BACKGROUND: Fabry disease (FD) is an X-linked lysosomal storage disorder caused by α-Gal A (α-galactosidase A) deficiency, resulting in multiorgan accumulation of sphingolipid, namely globotriaosylceramide. This triggers ventricular myocar…

Use of ElectroMap 2, a novel software, to investigate sympathetic nervous regulation of ventricular fibrillation Open

Christopher O’Shea, James Winter, Andrew P. Holmes, Kashif Rajpoot, Davor Pavlović · 2025

Early atrial remodelling drives arrhythmia in Fabry Disease Open

Ashwin Roy, Christopher O’Shea, Albert Dasi I Martinez, Leena Patel, Max Cumberland , et al. · 2024

Background Fabry disease (FD) is an X-linked lysosomal storage disorder caused by α-galactosidase A (α-Gal A) deficiency, resulting in multi-organ accumulation of sphingolipid, namely globotriaosylceramide (Gb3). This triggers ventricular …

BS12 Succinate disrupts human and mouse atrial action potentials and modifies sodium channel kinetics Open

Sean Benson, Molly O’Reilly, Max Cumberland, Andrew M. Coney, Katja Gehmlich , et al. · 2024

Introduction Mitochondrial succinate metabolism in the heart during acute or chronic hypoxia is a major cause of cellular death and dysfunction. However, its impact on cardiac electrical function is largely unknown. This could be of import…

BS52 Exploring the direct impact of sodium-glucose cotransporter 2 inhibitors on cardiac electrophysiology: insights from cellular models and murine hearts Open

Rina Sha, Olivia Baines, Andrew P. Holmes, Christopher O’Shea, Davor Pavlović · 2024

Background Sodium-glucose cotransporter 2 (SGLT2) inhibitors, an effective treatment for diabetes, have recently shown significant cardiac protective properties including a potential reduction in arrhythmias. The direct effects of SGLT2 in…

Arrhythmogenesis in Fabry Disease Open

Ashwin Roy, Max J. Cumberland, Christopher O’Shea, Andrew P. Holmes, Manish Kalla , et al. · 2024

Generation of a human iPSC-derived cardiomyocyte/fibroblast engineered heart tissue model Open

Max J. Cumberland, Jonas Euchner, Amar J. Azad, Nguyen T.N. Vo, Paulus Kirchhof , et al. · 2024

Animal models have proven integral to broadening our understanding of complex cardiac diseases but have been hampered by significant species-dependent differences in cellular physiology. Human-induced pluripotent stem cell-derived cardiomy…

Reduced plakoglobin increases the risk of sodium current defects and atrial conduction abnormalities in response to androgenic anabolic steroid abuse Open

Laura C. Sommerfeld, Andrew P. Holmes, Ting Yu, Christopher O’Shea, Deirdre M. Kavanagh , et al. · 2024

Androgenic anabolic steroids (AAS) are commonly abused by young men. Male sex and increased AAS levels are associated with earlier and more severe manifestation of common cardiac conditions, such as atrial fibrillation, and rare ones, such…

Publisher Correction: High resolution optical mapping of cardiac electrophysiology in pre-clinical models Open

Christopher O’Shea, James Winter, S. Nashitha Kabir, Molly O’Reilly, Simon P. Wells , et al. · 2024

Optical mapping and optogenetics in cardiac electrophysiology research and therapy: a state-of-the-art review Open

Olivia Baines, Rina Sha, Manish Kalla, Andrew P. Holmes, Igor R. Efimov , et al. · 2024

State-of-the-art innovations in optical cardiac electrophysiology are significantly enhancing cardiac research. A potential leap into patient care is now on the horizon. Optical mapping, using fluorescent probes and high-speed cameras, off…

Impact of Obesity on Atrial Fibrillation Pathogenesis and Treatment Options Open

Rina Sha, Olivia Baines, Abbie Hayes, Katie Tompkins, Manish Kalla , et al. · 2023

Atrial fibrillation (AF) is the most common cardiac arrhythmia. AF increases the risk of stroke, heart failure, dementia, and hospitalization. Obesity significantly increases AF risk, both directly and indirectly, through related condition…

Generation of a human iPSC-derived cardiomyocyte/fibroblast engineered heart tissue model Open

Max J. Cumberland, Jonas Euchner, Amar J. Azad, Nguyen T.N. Vo, Paulus Kirchhof , et al. · 2023

Animal models have proven integral to broadening our understanding of complex cardiac diseases but have been hampered by significant species-dependent differences in cellular physiology. Human-induced pluripotent stem cell-derived cardiomy…

Discitis and Osteomyelitis Caused by a Migrated Laparoscopic Adjustable Gastric Banding (LAGB) Catheter Open

Tanner Redlin, Andrew P. Holmes, Megan Albertson · 2023

Mechanisms of Atrial Fibrillation in Obstructive Sleep Apnoea Open

James Saleeb-Mousa, Demitris Nathanael, Andrew M. Coney, Manish Kalla, Keith L. Brain , et al. · 2023

Obstructive sleep apnoea (OSA) is a strong independent risk factor for atrial fibrillation (AF). Emerging clinical data cite adverse effects of OSA on AF induction, maintenance, disease severity, and responsiveness to treatment. Prevention…

Low sugar and the drive to breathe: Is insulin another adequate stimulus for the carotid body? Open

Andrew P. Holmes, Prem Kumar · 2023

Analyzing Angiotensin II Receptor Type 1 Clustering in PC12 Cells in Response to Hypoxia Using Direct Stochastic Optical Reconstruction Microscopy (dSTORM) Open

Hayyaf S. Aldossary, Daniel J. Nieves, Deirdre M. Kavanagh, Dylan M. Owen, Clare J. Ray , et al. · 2023

Familial atrial fibrillation mutation M1875T-SCN5A increases early sodium current and dampens the effect of flecainide Open

Molly O’Reilly, Laura C. Sommerfeld, Christopher O’Shea, Sophie Broadway‐Stringer, S Andaleeb , et al. · 2022

Aims Atrial fibrillation (AF) is the most common cardiac arrhythmia. Pathogenic variants in genes encoding ion channels are associated with familial AF. The point mutation M1875T in the SCN5A gene, which encodes the α-subunit of the cardia…

Exploring the neurogenic differentiation of human dental pulp stem cells Open

Arwa A. Al‐Maswary, Molly O’Reilly, Andrew P. Holmes, A. D. Walmsley, Paul R. Cooper , et al. · 2022

Human dental pulp stem cells (hDPSCs) have increasingly gained interest as a potential therapy for nerve regeneration in medicine and dentistry, however their neurogenic potential remains a matter of debate. This study aimed to characteriz…

Publisher Correction: LKB1 is the gatekeeper of carotid body chemosensing and the hypoxic ventilatory response Open

Sandy MacMillan, Andrew P. Holmes, Mark Dallas, Amira D. Mahmoud, Michael J. Shipston , et al. · 2022

Correction to: Communications Biology https://doi.org/10.1038/s42003-022-03583-7, published online 29 June 2022.

LKB1 is the gatekeeper of carotid body chemosensing and the hypoxic ventilatory response Open

Sandy MacMillan, Andrew P. Holmes, Mark Dallas, Amira D. Mahmoud, Michael J. Shipston , et al. · 2022

LKB1 is the gatekeeper of carotid body chemo-sensing and the hypoxic ventilatory response: deficiency precipitates Cheyne Stokes breathing Open

Sandy MacMillan, Andrew P. Holmes, Mark Dallas, Amira D. Mahmoud, Michael J. Shipston , et al. · 2022

The hypoxic ventilatory response (HVR) is critical to breathing and thus oxygen supply to the body and is primarily mediated by the carotid bodies. Here we reveal that carotid body afferent discharge during hypoxia and hypercapnia is deter…

Male sex hormone and reduced plakoglobin jointly impair atrial conduction and cardiac sodium currents Open

Laura C. Sommerfeld, Andrew P. Holmes, Ting Yu, Christopher O’Shea, Deirdre M. Kavanagh , et al. · 2022

Androgenic anabolic steroids (AAS) are commonly abused by young men. Male sex associates with earlier manifestation of common and rare cardiac conditions including atrial fibrillation and arrhythmogenic right ventricular cardiomyopathy (AR…

Are Multiple Mitochondrial Related Signalling Pathways Involved in Carotid Body Oxygen Sensing? Open

Andrew P. Holmes, Agnieszka Swiderska, Demitris Nathanael, Hayyaf S. Aldossary, Clare J. Ray , et al. · 2022

It is generally acknowledged that the carotid body (CB) type I cell mitochondria are unique, being inhibited by relatively small falls in P a O 2 well above those known to inhibit electron transport in other cell types. This feature is sug…

LKB1 is the gatekeeper of carotid body chemo-sensing and the hypoxic ventilatory response Open

Sandy MacMillan, Andrew P. Holmes, Mark Dallas, Amira D. Mahmoud, Michael J. Shipston , et al. · 2022

The hypoxic ventilatory response (HVR) is critical to breathing and thus oxygen supply to the body and is primarily mediated by the carotid bodies. Here we reveal that carotid body afferent discharge during hypoxia and hypercapnia is deter…

High resolution optical mapping of cardiac electrophysiology in pre-clinical models Open

Christopher O’Shea, James Winter, S. Nashitha Kabir, Molly O’Reilly, Simon P. Wells , et al. · 2022

Basic Research Approaches to Evaluate Cardiac Arrhythmia in Heart Failure and Beyond Open

Max J. Cumberland, Leto Luana Riebel, Ashwin Roy, Christopher O’Shea, Andrew P. Holmes , et al. · 2022

Patients with heart failure often develop cardiac arrhythmias. The mechanisms and interrelations linking heart failure and arrhythmias are not fully understood. Historically, research into arrhythmias has been performed on affected individ…

Increased atrial effectiveness of flecainide conferred by altered biophysical properties of sodium channels Open

Sian O' Brien, Andrew P. Holmes, Daniel M. Johnson, S. Nashitha Kabir, Christopher O' Shea , et al. · 2022

Increased early sodium current causes familial atrial fibrillation and dampens effect of flecainide Open

Molly O’Reilly, Laura C. Sommerfeld, Christopher O’Shea, Sophie Broadway‐Stringer, S Andaleeb , et al. · 2022

(1) Aims Atrial fibrillation (AF) is the most common cardiac arrhythmia. Pathogenic variants in genes encoding ion channels are associated with familial AF. The point mutation M1875T in the SCN5A gene, which encodes the α-subunit of the ca…

Mouse Left Atria Optical Mapping Data Open

Ming Lei, Davor Pavlović, Larissa Fabritz, Christopher O’Shea, James Winter , et al. · 2022

All data are provided in .mat format, and organised so that each folder contains an individual experiment (i.e. whole heart or isolated atrium). All PCLs are within single experimental files. .txt are also provided that contain suggested s…

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