Andrew P. Prescot
YOU?
Author Swipe
View article: Weekly sleep loss is associated with reduced cortical glutathione and antioxidant capacity in adolescents
Weekly sleep loss is associated with reduced cortical glutathione and antioxidant capacity in adolescents Open
View article: Glutamate measurements using edited MRS
Glutamate measurements using edited MRS Open
Purpose To demonstrate J‐ difference coediting of glutamate using Hadamard encoding and reconstruction of Mescher‐Garwood‐edited spectroscopy (HERMES). Methods Density‐matrix simulations of HERMES (TE 80 ms) and 1D J ‐resolved (TE 31–229 m…
View article: Examination of gamma-aminobutyric acid and glutamate-glutamine levels in association with impulsive behavior in adolescent marijuana users
Examination of gamma-aminobutyric acid and glutamate-glutamine levels in association with impulsive behavior in adolescent marijuana users Open
View article: Supplementation with a putative calorie restriction mimetic micronutrient blend increases glutathione concentrations and improves neuroenergetics in brain of healthy middle-aged men and women
Supplementation with a putative calorie restriction mimetic micronutrient blend increases glutathione concentrations and improves neuroenergetics in brain of healthy middle-aged men and women Open
The present study reveals that 6-weeks daily supplementation with a micronutrient blend elicits positive changes in brain neurochemistry. This is the first study to demonstrate that a putative CR mimetic increases brain GSH concentrations …
View article: An exploratory proton MRS examination of gamma-aminobutyric acid, glutamate, and glutamine and their relationship to affective aspects of chronic pain
An exploratory proton MRS examination of gamma-aminobutyric acid, glutamate, and glutamine and their relationship to affective aspects of chronic pain Open
Veterans experience chronic pain more frequently than civilians. Identification of neurobiological mechanisms underlying the pathophysiology of chronic pain in a veteran population may aid in the development of novel treatment targets. In …
View article: Intraindividual changes in brain GABA, glutamate, and glutamine during monitored abstinence from alcohol in treatment‐naive individuals with alcohol use disorder
Intraindividual changes in brain GABA, glutamate, and glutamine during monitored abstinence from alcohol in treatment‐naive individuals with alcohol use disorder Open
Proton magnetic resonance spectroscopy ( 1 H‐MRS) studies have demonstrated abnormal levels of a variety of neurometabolites in treatment‐seeking individuals with moderate‐severe alcohol use disorder (AUD) following acute withdrawal. In co…
View article: Evidence for a unique association between fronto-cortical glycine levels and recent heavy drinking in treatment naïve individuals with alcohol use disorder
Evidence for a unique association between fronto-cortical glycine levels and recent heavy drinking in treatment naïve individuals with alcohol use disorder Open
View article: Reduced gamma-amino butyric acid (GABA) and glutamine in the anterior cingulate cortex (ACC) of veterans exposed to trauma
Reduced gamma-amino butyric acid (GABA) and glutamine in the anterior cingulate cortex (ACC) of veterans exposed to trauma Open
Exposure to trauma in veterans may be associated with lower GABA/H2O and Gln/H2O in the dACC, suggesting disruption in the GABA-Gln-glutamate cycle. Further, altered Glu/GABA in the dACC in the PTSD group may indicate…
View article: Brain Glutamate, GABA, and Glutamine Levels and Associations with Recent Drinking in Treatment‐Naïve Individuals with Alcohol Use Disorder Versus Light Drinkers
Brain Glutamate, GABA, and Glutamine Levels and Associations with Recent Drinking in Treatment‐Naïve Individuals with Alcohol Use Disorder Versus Light Drinkers Open
Background Proton magnetic resonance spectroscopy ( 1 H‐ MRS ) studies have demonstrated abnormal levels of a variety of neurometabolites in inpatients/outpatients with alcohol use disorder ( AUD ) following acute alcohol withdrawal relati…
View article: Two-Dimensional Proton Magnetic Resonance Spectroscopy versus J-Editing for GABA Quantification in Human Brain: Insights from a GABA-Aminotransferase Inhibitor Study
Two-Dimensional Proton Magnetic Resonance Spectroscopy versus J-Editing for GABA Quantification in Human Brain: Insights from a GABA-Aminotransferase Inhibitor Study Open
View article: Altered Cortical Gamma-Amino Butyric Acid in Female Veterans With Suicidal Behavior: Sex Differences and Clinical Correlates
Altered Cortical Gamma-Amino Butyric Acid in Female Veterans With Suicidal Behavior: Sex Differences and Clinical Correlates Open
Background Suicide is a public health concern in the civilian and veteran populations. Stressful life events are precipitating factors for suicide. The neurochemical underpinnings of the association between stress/trauma and suicide risk a…
View article: Hippocampal GABA enables inhibitory control over unwanted thoughts
Hippocampal GABA enables inhibitory control over unwanted thoughts Open
View article: In Vivo Detection of CPP-115 Target Engagement in Human Brain
In Vivo Detection of CPP-115 Target Engagement in Human Brain Open
View article: Unique prefrontal GABA and glutamate disturbances in co-occurring bipolar disorder and alcohol dependence
Unique prefrontal GABA and glutamate disturbances in co-occurring bipolar disorder and alcohol dependence Open
Bipolar disorder (BD) and alcohol dependence (AD) frequently co-occur, and co-occurring BD and AD are associated with devastating public health costs. Minimal neurobiological research exists to guide the development of effective treatments…
View article: Associations Between Recent Heavy Drinking and Dorsal Anterior Cingulate<i>N</i>-Acetylaspartate and Glutamate Concentrations in Non-Treatment-Seeking Individuals with Alcohol Dependence
Associations Between Recent Heavy Drinking and Dorsal Anterior Cingulate<i>N</i>-Acetylaspartate and Glutamate Concentrations in Non-Treatment-Seeking Individuals with Alcohol Dependence Open
This study extends the literature by demonstrating inverse associations between recent heavy drinking and dACC glutamate and NAA concentrations in a sample of nonsevere, non-treatment-seeking individuals with AD. These findings may support…
View article: A ‘complex’ of brain metabolites distinguish altered chemistry in the cingulate cortex of episodic migraine patients
A ‘complex’ of brain metabolites distinguish altered chemistry in the cingulate cortex of episodic migraine patients Open
Despite the prevalence of migraine, the pathophysiology of the disease remains unclear. Current understanding of migraine has alluded to the possibility of a hyperexcitable brain. The aim of the current study is to investigate human brain …
View article: NIMG-08EVALUATION OF 2HG MR SPECTROSCOPY IN RELATION TO DISEASE ACTIVITY IN GLIOMAS
NIMG-08EVALUATION OF 2HG MR SPECTROSCOPY IN RELATION TO DISEASE ACTIVITY IN GLIOMAS Open
The oncometabolite 2-hydroxyglutarate (2HG) is produced by mutated isocitrate dehydrogenase (IDH). Magnetic resonance spectroscopy (MRS) detects 2HG noninvasively and has been reported to accurately identify IDH mutated tumors. 2HG-MRS may…
View article: Final Program Addendum Forty Third Annual Meeting International Neuropsychological Society February 4–7, 2015 Denver, Colorado, USA
Final Program Addendum Forty Third Annual Meeting International Neuropsychological Society February 4–7, 2015 Denver, Colorado, USA Open
An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
View article: Molecular features assisting in diagnosis, surgery, and treatment decision making in low-grade gliomas
Molecular features assisting in diagnosis, surgery, and treatment decision making in low-grade gliomas Open
The preferred management of suspected low-grade gliomas (LGGs) has been disputed, and the implications of molecular changes for medical and surgical management of LGGs are important to consider. Current strategies that make use of molecula…