Andrew R. Castle
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View article: Single extracellular vesicle detection assay identifies membrane-associated α-synuclein as an early-stage biomarker in Parkinson’s disease
Single extracellular vesicle detection assay identifies membrane-associated α-synuclein as an early-stage biomarker in Parkinson’s disease Open
View article: Prion Protein Endoproteolysis: Cleavage Sites, Mechanisms and Connections to Prion Disease
Prion Protein Endoproteolysis: Cleavage Sites, Mechanisms and Connections to Prion Disease Open
Highly abundant in neurons, the cellular prion protein (PrP C ) is an obligatory precursor to the disease‐associated misfolded isoform denoted PrP Sc that accumulates in the rare neurodegenerative disorders referred to either as transmissi…
View article: Monitoring α-synuclein ubiquitination dynamics reveals key endosomal effectors mediating its trafficking and degradation
Monitoring α-synuclein ubiquitination dynamics reveals key endosomal effectors mediating its trafficking and degradation Open
While defective α-synuclein homeostasis is central to Parkinson’s pathogenesis, fundamental questions about its degradation remain unresolved. We have developed a bimolecular fluorescence complementation assay in living cells to monitor de…
View article: Beta-endoproteolysis of the cellular prion protein by dipeptidyl peptidase-4 and fibroblast activation protein
Beta-endoproteolysis of the cellular prion protein by dipeptidyl peptidase-4 and fibroblast activation protein Open
The cellular prion protein (PrP C ) converts to alternatively folded pathogenic conformations (PrP Sc ) in prion infections and binds neurotoxic oligomers formed by amyloid-β α-synuclein, and tau. β-Endoproteolysis, which splits PrP C into…
View article: Investigating CRISPR/Cas9 gene drive for production of disease-preventing prion gene alleles
Investigating CRISPR/Cas9 gene drive for production of disease-preventing prion gene alleles Open
Prion diseases are a group of fatal neurodegenerative disorders that includes chronic wasting disease, which affects cervids and is highly transmissible. Given that chronic wasting disease prevalence exceeds 30% in some endemic areas of No…
View article: Susceptibility of Beavers to Chronic Wasting Disease
Susceptibility of Beavers to Chronic Wasting Disease Open
Chronic wasting disease (CWD) is a contagious, fatal, neurodegenerative prion disease of cervids. The expanding geographical range and rising prevalence of CWD are increasing the risk of pathogen transfer and spillover of CWD to non-cervid…
View article: Prion protein with a mutant N-terminal octarepeat region undergoes cobalamin-dependent assembly into high–molecular weight complexes
Prion protein with a mutant N-terminal octarepeat region undergoes cobalamin-dependent assembly into high–molecular weight complexes Open
View article: Author Index
Author Index Open
View article: Application of high-throughput, capillary-based Western analysis to modulated cleavage of the cellular prion protein
Application of high-throughput, capillary-based Western analysis to modulated cleavage of the cellular prion protein Open
View article: Physiological Functions of the Cellular Prion Protein
Physiological Functions of the Cellular Prion Protein Open
The prion protein, PrPC, is a small, cell-surface glycoprotein notable primarily for its critical role in pathogenesis of the neurodegenerative disorders known as prion diseases. A hallmark of prion diseases is the conversion of…