Andrew R. Hamel
YOU?
Author Swipe
View article: Genome-wide meta-analysis identifies 22 loci for normal tension glaucoma with significant overlap with high tension glaucoma
Genome-wide meta-analysis identifies 22 loci for normal tension glaucoma with significant overlap with high tension glaucoma Open
View article: QTL mapping of human retina DNA methylation identifies 87 gene-epigenome interactions in age-related macular degeneration
QTL mapping of human retina DNA methylation identifies 87 gene-epigenome interactions in age-related macular degeneration Open
DNA methylation provides a crucial epigenetic mark linking genetic variations to environmental influence. We have analyzed array-based DNA methylation profiles of 160 human retinas with co-measured RNA-seq and >8 million genetic variants, …
View article: Integrating genetic regulation and single-cell expression with GWAS prioritizes causal genes and cell types for glaucoma
Integrating genetic regulation and single-cell expression with GWAS prioritizes causal genes and cell types for glaucoma Open
View article: QTL mapping of human retina DNA methylation identifies 87 gene-epigenome interactions in age-related macular degeneration
QTL mapping of human retina DNA methylation identifies 87 gene-epigenome interactions in age-related macular degeneration Open
The summary statistics (nominal p-values, beta and standard error) for all significant variant-CpG pair mQTLs, all significant variant-gene pair eQTLs, and all significant CpG-gene pair eQTMs identified in retina in the Advani et al., http…
View article: QTL mapping of human retina DNA methylation identifies 87 gene-epigenome interactions in age-related macular degeneration
QTL mapping of human retina DNA methylation identifies 87 gene-epigenome interactions in age-related macular degeneration Open
The summary statistics (nominal p-values, beta and standard error) for all significant variant-CpG pair mQTLs, all significant variant-gene pair eQTLs, and all significant CpG-gene pair eQTMs identified in the Advani et al., https://www.re…
View article: QTL mapping of human retina DNA methylation identifies 87 gene-epigenome interactions in age-related macular degeneration
QTL mapping of human retina DNA methylation identifies 87 gene-epigenome interactions in age-related macular degeneration Open
The summary statistics (nominal p-values, beta and standard error) for all significant variant-CpG pair mQTLs, all significant variant-gene pair eQTLs, and all significant CpG-gene pair eQTMs identified in retina in the Advani et al., http…
View article: Large-scale multitrait genome-wide association analyses identify hundreds of glaucoma risk loci
Large-scale multitrait genome-wide association analyses identify hundreds of glaucoma risk loci Open
View article: QTL mapping of human retina DNA methylation identifies 87 gene-epigenome interactions in age-related macular degeneration
QTL mapping of human retina DNA methylation identifies 87 gene-epigenome interactions in age-related macular degeneration Open
DNA methylation (DNAm) provides a crucial epigenetic mark linking genetic variations to environmental influence. We analyzed array-based DNAm profiles of 160 human retinas with co-measured RNA-seq and > 8 million genetic variants, uncoveri…
View article: Integrating genetic regulation and single-cell expression with GWAS prioritizes causal genes and cell types for glaucoma
Integrating genetic regulation and single-cell expression with GWAS prioritizes causal genes and cell types for glaucoma Open
Primary open-angle glaucoma (POAG), characterized by retinal ganglion cell death, is a leading cause of irreversible blindness worldwide; however, the molecular and cellular causes are not well understood. Elevated intraocular pressure (IO…
View article: ECLIPSER: identifying causal cell types and genes for complex traits through single cell enrichment of e/sQTL-mapped genes in GWAS loci
ECLIPSER: identifying causal cell types and genes for complex traits through single cell enrichment of e/sQTL-mapped genes in GWAS loci Open
Summary ECLIPSER was developed to identify pathogenic cell types and cell type-specific genes that may affect complex disease susceptibility and trait variation by integrating single cell data with known GWAS loci. ECLIPSER maps genes to G…
View article: Data used in ECLIPSER methods paper and GTEx snRNA-seq cross-tissue reference map analysis
Data used in ECLIPSER methods paper and GTEx snRNA-seq cross-tissue reference map analysis Open
The tables were used in the papers: Rouhana*, Wang* et al., ECLIPSER: identifying causal cell types and genes for complex traits through single cell enrichment of e/sQTL-mapped genes in GWAS loci, bioRxiv 2021, doi: https://doi.or…
View article: Data used in ECLIPSER methods paper and GTEx snRNA-seq cross-tissue reference map analysis
Data used in ECLIPSER methods paper and GTEx snRNA-seq cross-tissue reference map analysis Open
The tables were used in the papers: Rouhana*, Wang* et al., ECLIPSER: identifying causal cell types and genes for complex traits through single cell enrichment of e/sQTL-mapped genes in GWAS loci, bioRxiv 2021, doi: https://doi.or…
View article: Data used in ECLIPSER methods paper and GTEx snRNA-seq cross-tissue reference map analysis
Data used in ECLIPSER methods paper and GTEx snRNA-seq cross-tissue reference map analysis Open
The tables were used in the papers: Rouhana*, Wang* et al., ECLIPSER: identifying causal cell types and genes for complex traits through single cell enrichment of e/sQTL-mapped genes in GWAS loci, bioRxiv 2021, doi: https://doi.or…
View article: Data used in ECLIPSER methods paper and GTEx snRNA-seq cross-tissue reference map analysis
Data used in ECLIPSER methods paper and GTEx snRNA-seq cross-tissue reference map analysis Open
The tables were used in the papers: Rouhana*, Wang* et al., ECLIPSER: identifying causal cell types and genes for complex traits through single cell enrichment of e/sQTL-mapped genes in GWAS loci, bioRxiv 2021, doi: https://doi.or…
View article: Population-scale tissue transcriptomics maps long non-coding RNAs to complex disease
Population-scale tissue transcriptomics maps long non-coding RNAs to complex disease Open
View article: Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries
Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries Open
Primary open-angle glaucoma (POAG), is a heritable common cause of blindness world-wide. To identify risk loci, we conduct a large multi-ethnic meta-analysis of genome-wide association studies on a total of 34,179 cases and 349,321 control…
View article: Exploiting the GTEx resources to decipher the mechanisms at GWAS loci
Exploiting the GTEx resources to decipher the mechanisms at GWAS loci Open
View article: Additional file 3 of Exploiting the GTEx resources to decipher the mechanisms at GWAS loci
Additional file 3 of Exploiting the GTEx resources to decipher the mechanisms at GWAS loci Open
Additional file 3 Presumed causal genes included in the OMIM database
View article: Additional file 2 of Exploiting the GTEx resources to decipher the mechanisms at GWAS loci
Additional file 2 of Exploiting the GTEx resources to decipher the mechanisms at GWAS loci Open
Additional file 2 The metadata of the full list of 114 GWASs
View article: Additional file 5 of Exploiting the GTEx resources to decipher the mechanisms at GWAS loci
Additional file 5 of Exploiting the GTEx resources to decipher the mechanisms at GWAS loci Open
Additional file 5 BioVU table
View article: Additional file 8 of Exploiting the GTEx resources to decipher the mechanisms at GWAS loci
Additional file 8 of Exploiting the GTEx resources to decipher the mechanisms at GWAS loci Open
Additional file 8 PrediXcan and enloc results for predicted causal genes selected based on OMIM
View article: Additional file 4 of Exploiting the GTEx resources to decipher the mechanisms at GWAS loci
Additional file 4 of Exploiting the GTEx resources to decipher the mechanisms at GWAS loci Open
Additional file 4 Genes suggested as causal by rare variant association studies
View article: Additional file 7 of Exploiting the GTEx resources to decipher the mechanisms at GWAS loci
Additional file 7 of Exploiting the GTEx resources to decipher the mechanisms at GWAS loci Open
Additional file 7 Rare variant silver standard genes included in the analysis
View article: Additional file 6 of Exploiting the GTEx resources to decipher the mechanisms at GWAS loci
Additional file 6 of Exploiting the GTEx resources to decipher the mechanisms at GWAS loci Open
Additional file 6 OMIM genes included in the analysis
View article: Additional file 9 of Exploiting the GTEx resources to decipher the mechanisms at GWAS loci
Additional file 9 of Exploiting the GTEx resources to decipher the mechanisms at GWAS loci Open
Additional file 9 PrediXcan and enloc results for presumed causal genes in the rare variant based silver standard
View article: A Quantitative Proteome Map of the Human Body
A Quantitative Proteome Map of the Human Body Open
View article: Cell type–specific genetic regulation of gene expression across human tissues
Cell type–specific genetic regulation of gene expression across human tissues Open
Cell type composition, estimated from bulk tissue, maps the cellular specificity of genetic variants.
View article: The impact of sex on gene expression across human tissues
The impact of sex on gene expression across human tissues Open
Sex differences in the human transcriptome are widespread and tissue specific, and they contribute to complex traits.
View article: Glucocorticoid receptor binding sites are enriched for genetic associations with intraocular pressure variation
Glucocorticoid receptor binding sites are enriched for genetic associations with intraocular pressure variation Open
View article: GTEx v8 SMR sQTL results
GTEx v8 SMR sQTL results Open
SMR results using sQTLs from GTEx (release 8) # Data usage policy When using this data, you must acknowledge the source by citing the publication "Widespread dose-dependent effects of RNA expression and splicing on complex diseases and tra…