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View article: Metabolic Characterization of Deceased Donor Kidneys Undergoing Hypothermic Machine Perfusion Before Transplantation Using 13C-enriched Glucose
Metabolic Characterization of Deceased Donor Kidneys Undergoing Hypothermic Machine Perfusion Before Transplantation Using 13C-enriched Glucose Open
Background. The provision of a metabolic substrate is one mechanism by which hypothermic machine perfusion (HMP) of kidneys provides clinical benefit. This study aimed to describe de novo metabolism in ex vivo human kidneys undergoing HMP …
View article: Management of Parathyroid Disease during the COVID-19 Pandemic
Management of Parathyroid Disease during the COVID-19 Pandemic Open
The coronavirus disease, COVID-19, has caused widespread and sustained disruption to healthcare, not only in the delivery of emergency care, but knock-on consequences have resulted in major delays to the delivery of elective care, includin…
View article: ShearFAST: a user-friendly<i>in vitro</i>toolset for high throughput, inexpensive fluid shear stress experiments
ShearFAST: a user-friendly<i>in vitro</i>toolset for high throughput, inexpensive fluid shear stress experiments Open
Fluid shear stress is a key modulator of cellular physiology in vitro and in vivo , but its effects are under-investigated due to requirements for complicated induction methods. Herein we report the validation of ShearFAST; a smartphone ap…
View article: Late Breaking Poster
Late Breaking Poster Open
Introduction and Aim: It is a genetic and metabolic disease characterized by accumulation of metabolic wastes in lysozomes as a result of muopolysaccharides that have been destroyed in the body.In this study, care of the child with mucopol…
View article: Recipient Outcomes From Nondirected Live Kidney Donors: A UK-based Cohort Study
Recipient Outcomes From Nondirected Live Kidney Donors: A UK-based Cohort Study Open
Background Increasing numbers of patients with end-stage renal failure are receiving kidneys from nondirected kidney donors (NKDs), also known as altruistic donors. Transplant outcomes for recipients of such kidneys are largely inferred fr…
View article: The impact of donor body mass index on outcomes after deceased kidney transplantation - a national population-cohort study
The impact of donor body mass index on outcomes after deceased kidney transplantation - a national population-cohort study Open
The aim of this study was to determine the effect of donor body mass index (BMI) on deceased donor kidney transplant outcomes. Data were collected from the UK Transplant Registry for all deceased donor kidney transplant recipients between …
View article: Outcomes of donation after circulatory death kidneys undergoing hypothermic machine perfusion following static cold storage: A UK population-based cohort study
Outcomes of donation after circulatory death kidneys undergoing hypothermic machine perfusion following static cold storage: A UK population-based cohort study Open
Evidence is currently lacking regarding the outcomes of kidneys undergoing hypothermic machine perfusion (HMP) in patients in the United Kingdom. Using the National Health Service Blood and Transplant database, the authors compared outcome…
View article: 13C glucose labelling studies using 2D NMR are a useful tool for determining ex vivo whole organ metabolism during hypothermic machine perfusion of kidneys
13C glucose labelling studies using 2D NMR are a useful tool for determining ex vivo whole organ metabolism during hypothermic machine perfusion of kidneys Open
This study conclusively demonstrates that de novo metabolism occurs during HMP and highlights active metabolic pathways in this hypothermic, hypoxic environment. Whilst the majority of the (13)C-enriched glucose is metabolised into glycoly…
View article: Effect of cold ischaemia time on outcome after living donor renal transplantation
Effect of cold ischaemia time on outcome after living donor renal transplantation Open
Background The aim of the present study was to determine the effects of cold ischaemia time (CIT) on living donor kidney transplant recipients in a large national data set. Methods Data from the National Health Service Blood and Transplant…
View article: Manipulating the HIF Pathway in Renal Transplantation, Current Progress and Future Developments
Manipulating the HIF Pathway in Renal Transplantation, Current Progress and Future Developments Open
Renal transplantation is the gold standard treatment for end stage renal disease; however, there are currently not enough suitable organs to meet a growing demand. The Hypoxia Inducible Factor (HIF) pathway comprises a number of oxygen sen…