Andrew Rhodes
YOU?
Author Swipe
View article: Rationale and Methodological Approach Underlying the Development of the Sequential Organ Failure Assessment (SOFA)–2 Score
Rationale and Methodological Approach Underlying the Development of the Sequential Organ Failure Assessment (SOFA)–2 Score Open
Importance The Sequential Organ Failure Assessment (SOFA) score was published in 1996 to describe organ dysfunction in critically ill adult patients in a readily quantifiable and sequential manner. Considerable changes have occurred over t…
View article: Intravenous Clarithromycin in Critically Ill Adults: A Population Pharmacokinetic Study
Intravenous Clarithromycin in Critically Ill Adults: A Population Pharmacokinetic Study Open
Background: Clarithromycin is a commonly used macrolide antibiotic. Infection is a major source of mortality and morbidity in critical care units. Pharmacokinetics may vary during critical illness and suboptimal antimicrobial exposure has …
View article: Levetiracetam dosing in continuous renal replacement therapy: A systematic review and development of a novel pharmacokinetic model to optimise dosing in critically ill patients. Do recommended doses achieve therapeutic drug concentrations?
Levetiracetam dosing in continuous renal replacement therapy: A systematic review and development of a novel pharmacokinetic model to optimise dosing in critically ill patients. Do recommended doses achieve therapeutic drug concentrations? Open
Aim: Levetiracetam is a widely used anti-epileptic in the critical care setting that is almost exclusively (>90%) renally excreted. The altered pharmacokinetics of levetiracetam have been widely studied in intermittent haemodialysis but th…
View article: Intravenous Clarithromycin in Critically Unwell Adults: A Population Pharmacokinetic Study
Intravenous Clarithromycin in Critically Unwell Adults: A Population Pharmacokinetic Study Open
Clarithromycin is a commonly used macrolide antibiotic. Infection is a major source of mortality and morbidity in critical care units. Pharmacokinetics may vary during critical illness and suboptimal pharmacokinetic exposure of antimicrobi…
View article: Bloodstream Infections in Critical Care Units in England, April 2017 to March 2023: Results from the First Six Years of a National Surveillance Programme
Bloodstream Infections in Critical Care Units in England, April 2017 to March 2023: Results from the First Six Years of a National Surveillance Programme Open
Background: Patients in critical care units (CCUs) are at an increased risk of bloodstream infections (BSIs), which can be associated with central vascular catheters (CVCs). This study describes BSIs, CVC-BSIs, organism distribution, perce…
View article: Intensive Care Medicine in Portugal
Intensive Care Medicine in Portugal Open
publishersversion
View article: Intensive care unit caseload and workload and their association with outcomes in critically unwell patients: a large registry-based cohort analysis
Intensive care unit caseload and workload and their association with outcomes in critically unwell patients: a large registry-based cohort analysis Open
Background Too high or too low patient volumes and work amounts may overwhelm health care professionals and obstruct processes or lead to inadequate personnel routine and process flow. We sought to evaluate, whether an association between …
View article: Continuous vs Intermittent β-Lactam Antibiotic Infusions in Critically Ill Patients With Sepsis
Continuous vs Intermittent β-Lactam Antibiotic Infusions in Critically Ill Patients With Sepsis Open
Importance Whether β-lactam antibiotics administered by continuous compared with intermittent infusion reduces the risk of death in patients with sepsis is uncertain. Objective To evaluate whether continuous vs intermittent infusion of a β…
View article: A Genome-Wide Association Study of Serum Metabolite Profiles in Septic Shock Patients
A Genome-Wide Association Study of Serum Metabolite Profiles in Septic Shock Patients Open
OBJECTIVES: We sought to assess whether genetic associations with metabolite concentrations in septic shock patients could be used to identify pathways of potential importance for understanding sepsis pathophysiology. DESIGN: Retrospective…
View article: Por que o escore Sequential Organ Failure Assessment precisa ser atualizado?
Por que o escore Sequential Organ Failure Assessment precisa ser atualizado? Open
O escore Sequential Organ Failure Assessment (SOFA) foi desenvolvido há quase 30 anos. Rapidamente, tornou-se um dos sistemas de pontuação mais utilizados em terapia intensiva, tanto para a prática clínica quanto para a pesquisa,(,) e cont…
View article: Why the Sequential Organ Failure Assessment score needs updating?
Why the Sequential Organ Failure Assessment score needs updating? Open
The Sequential Organ Failure Assessment (SOFA) score was developed almost 30 years ago. It rapidly became one of the most widely used scoring systems in intensive care, both for clinical practice and research,(,) and remains one of the mos…
View article: Analysis of Fiber Attrition and Mechanical Performance in Large-Format Additive Manufacturing of Long-Fiber Reinforced Polymer Composites
Analysis of Fiber Attrition and Mechanical Performance in Large-Format Additive Manufacturing of Long-Fiber Reinforced Polymer Composites Open
View article: A systematic review of the effect of continuous renal replacement therapy on levetiracetam pharmacokinetics in critically ill patients. Do recommended doses achieve therapeutic drug concentrations?
A systematic review of the effect of continuous renal replacement therapy on levetiracetam pharmacokinetics in critically ill patients. Do recommended doses achieve therapeutic drug concentrations? Open
AIM Levetiracetam is a widely used anti-epileptic in the critical care setting that is almost exclusively (>90%) renally excreted. A significant number of critically unwell patients develop renal failure requiring haemofiltration. This pap…
View article: Real-world inter-observer variability of the sequential organ failure assessment (SOFA) score in intensive care medicine: the time has come for an update: authors’ reply
Real-world inter-observer variability of the sequential organ failure assessment (SOFA) score in intensive care medicine: the time has come for an update: authors’ reply Open
View article: Population Pharmacokinetic Study of Benzylpenicillin in Critically Unwell Adults
Population Pharmacokinetic Study of Benzylpenicillin in Critically Unwell Adults Open
Pharmacokinetics are highly variable in critical illness, and suboptimal antibiotic exposure is associated with treatment failure. Benzylpenicillin is a commonly used beta-lactam antibiotic, and pharmacokinetic data of its use in criticall…
View article: Prognostic performance of the REDS score, SOFA score, NEWS2 score, and the red-flag, NICE high-risk, and SIRS criteria to predict survival at 180 days, in emergency department patients admitted with suspected sepsis – An observational cohort study
Prognostic performance of the REDS score, SOFA score, NEWS2 score, and the red-flag, NICE high-risk, and SIRS criteria to predict survival at 180 days, in emergency department patients admitted with suspected sepsis – An observational cohort study Open
Background Patients admitted to hospital with sepsis are at persistent risk of poor outcome after discharge. Many tools are available to risk-stratify sepsis patients for in-hospital mortality. This study aimed to identify the best risk-st…
View article: Corrigendum to “Statistical analysis plan for the BLING III study: a phase 3 multicentre randomised controlled trial of continuous versus intermittent β-lactam antibiotic infusion in critically ill patients with sepsis” [Crit Care Resusc 23(3) (2021) 273–284]
Corrigendum to “Statistical analysis plan for the BLING III study: a phase 3 multicentre randomised controlled trial of continuous versus intermittent β-lactam antibiotic infusion in critically ill patients with sepsis” [Crit Care Resusc 23(3) (2021) 273–284] Open
View article: The Sequential Organ Failure Assessment (SOFA) Score: has the time come for an update?
The Sequential Organ Failure Assessment (SOFA) Score: has the time come for an update? Open
View article: Abstracts\' Service
Abstracts\' Service Open
Importance.The coronavirus disease 2019 pandemic, due to the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused a worldwide sudden and substantial increase in hospitalizations for pneumonia with multiorgan disea…
View article: Short-term mortality of patients ≥80 years old admitted to European intensive care units: an international observational study
Short-term mortality of patients ≥80 years old admitted to European intensive care units: an international observational study Open
View article: 892 Treatment variables associated with outcome in emergency department suspected sepsis
892 Treatment variables associated with outcome in emergency department suspected sepsis Open
Aims/Objectives/Background Early treatment is advocated in the management of patients with suspected sepsis. We sought to understand the association between the emergency department (ED) treatments and outcome in these patients. The treatm…
View article: Infection control in the intensive care unit: expert consensus statements for SARS-CoV-2 using a Delphi method
Infection control in the intensive care unit: expert consensus statements for SARS-CoV-2 using a Delphi method Open
View article: Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021
Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021 Open
INTRODUCTION Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to infection (1). Sepsis and septic shock are major healthcare problems, impacting millions of people around the world each year and killing b…
View article: Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021
Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021 Open
View article: Statistical analysis plan for the BLING III study: a phase 3 multicentre randomised controlled trial of continuous versus intermittent β-lactam antibiotic infusion in critically ill patients with sepsis
Statistical analysis plan for the BLING III study: a phase 3 multicentre randomised controlled trial of continuous versus intermittent β-lactam antibiotic infusion in critically ill patients with sepsis Open
View article: Relationship between the Clinical Frailty Scale and short-term mortality in patients ≥ 80 years old acutely admitted to the ICU: a prospective cohort study
Relationship between the Clinical Frailty Scale and short-term mortality in patients ≥ 80 years old acutely admitted to the ICU: a prospective cohort study Open
View article: Postoperative continuous positive airway pressure to prevent pneumonia, re-intubation, and death after major abdominal surgery (PRISM): a multicentre, open-label, randomised, phase 3 trial
Postoperative continuous positive airway pressure to prevent pneumonia, re-intubation, and death after major abdominal surgery (PRISM): a multicentre, open-label, randomised, phase 3 trial Open
View article: Reducing the global burden of sepsis: a positive legacy for the COVID-19 pandemic?
Reducing the global burden of sepsis: a positive legacy for the COVID-19 pandemic? Open
View article: Peripherally inserted central catheters: spreading the MAGIC beyond Michigan
Peripherally inserted central catheters: spreading the MAGIC beyond Michigan Open
Central venous access catheters are often used for patients requiring repeated infusions, blood sampling, invasive monitoring or where peripheral access is difficult. For intravenous access of up to 2 weeks in duration, a midline catheter …
View article: Clinician preferences for prescription of corticosteroids in patients with septic shock: an international survey
Clinician preferences for prescription of corticosteroids in patients with septic shock: an international survey Open