Andrew Riselli
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View article: Proteomic profiling reveals age-related changes in transporter proteins in the human blood–brain barrier
Proteomic profiling reveals age-related changes in transporter proteins in the human blood–brain barrier Open
The Blood–Brain Barrier (BBB) is a selective barrier that regulates the entry of molecules including nutrients, environmental toxins, and therapeutic medications into the brain. Its function continues to evolve postnatally, through aging, …
View article: Identification and Clinical Evaluation of Potential Biomarkers for Breast Cancer Resistance Protein (<scp>BCRP</scp>/<scp><i>ABCG2</i></scp>)
Identification and Clinical Evaluation of Potential Biomarkers for Breast Cancer Resistance Protein (<span>BCRP</span>/<span><i>ABCG2</i></span>) Open
Clinical inhibition and genetic variation of the Breast Cancer Resistance Protein (BCRP/ ABCG2 ) efflux transporter can significantly influence drug exposure, highlighting the need for reliable BCRP functional biomarkers. This study aimed …
View article: Proteomic Profiling Reveals Age-Related Changes in Transporter Proteins in the Human Blood-Brain Barrier
Proteomic Profiling Reveals Age-Related Changes in Transporter Proteins in the Human Blood-Brain Barrier Open
The Blood-Brain Barrier (BBB) is a crucial, selective barrier that regulates the entry of molecules including nutrients, environmental toxins, and therapeutic medications into the brain. This function relies heavily on brain endothelial ce…
View article: Protocol for producing hyperpolarized 13C-bicarbonate for clinical MRI of extracellular pH in aggressive tumors
Protocol for producing hyperpolarized 13C-bicarbonate for clinical MRI of extracellular pH in aggressive tumors Open
Tumor acidosis is one of the hallmarks indicating the initiation and progression of various cancers. Here, we present a protocol for preparing a hyperpolarized (HP) 13C-bicarbonate tissue pH MRI imaging contrast agent to detect aggressive …
View article: Clinically Translatable Hyperpolarized <sup>13</sup>C Bicarbonate pH Imaging Method for Use in Prostate Cancer
Clinically Translatable Hyperpolarized <sup>13</sup>C Bicarbonate pH Imaging Method for Use in Prostate Cancer Open
Solid tumors such as prostate cancer (PCa) commonly develop an acidic microenvironment with pH 6.5-7.2, owing to heterogeneous perfusion, high metabolic activity, and rapid cell proliferation. In preclinical prostate cancer models, disease…
View article: Probing Human Heart TCA Cycle Metabolism and Response to Glucose Load using Hyperpolarized [2-<sup>13</sup>C]Pyruvate MR Spectroscopy
Probing Human Heart TCA Cycle Metabolism and Response to Glucose Load using Hyperpolarized [2-<sup>13</sup>C]Pyruvate MR Spectroscopy Open
Summary Introduction The normal heart has remarkable metabolic flexibility that permits rapid switching between mitochondrial glucose oxidation and fatty acid (FA) oxidation to generate ATP. Loss of metabolic flexibility has been implicate…
View article: Characterization of P‐glycoprotein orthologs from human, sheep, pig, dog, and cat
Characterization of P‐glycoprotein orthologs from human, sheep, pig, dog, and cat Open
The ATP‐binding cassette transporter P‐glycoprotein (P‐gp) limits the oral bioavailability of many drugs. Although P‐gp has been well studied in humans and mice, little is known about the substrate specificities of many of its species orth…
View article: Development of specialized magnetic resonance acquisition techniques for human hyperpolarized [<sup>13</sup><scp>C</scp>,<sup>15</sup><scp>N<sub>2</sub></scp>]urea + [<scp>1‐</scp><sup>13</sup><scp>C</scp>]pyruvate simultaneous perfusion and metabolic imaging
Development of specialized magnetic resonance acquisition techniques for human hyperpolarized [<sup>13</sup><span>C</span>,<sup>15</sup><span>N<sub>2</sub></span>]urea + [<span>1‐</span><sup>13</sup><span>C</span>]pyruvate simultaneous perfusion and metabolic imaging Open
Purpose This study aimed to develop and demonstrate the in vivo feasibility of a 3D stack‐of‐spiral balanced steady‐state free precession(3D‐bSSFP) urea sequence, interleaved with a metabolite‐specific gradient echo (GRE) sequence for pyru…
View article: Naloxegol to Prevent Constipation in ICU Adults Receiving Opioids: A Randomized Double-Blind Placebo-Controlled Pilot Trial
Naloxegol to Prevent Constipation in ICU Adults Receiving Opioids: A Randomized Double-Blind Placebo-Controlled Pilot Trial Open
Background. Constipation is frequent in critically ill adults receiving opioids. Naloxegol (N), a peripherally acting mu-receptor antagonist (PAMORA), may reduce constipation. The objective of this trial was to evaluate the efficacy and sa…
View article: Clinical translation of hyperpolarized<sup>13</sup>C pyruvate and urea MRI for simultaneous metabolic and perfusion imaging
Clinical translation of hyperpolarized<sup>13</sup>C pyruvate and urea MRI for simultaneous metabolic and perfusion imaging Open
Purpose The combined hyperpolarized (HP) 13 C pyruvate and urea MRI has provided a simultaneous assessment of glycolytic metabolism and tissue perfusion for improved cancer diagnosis and therapeutic evaluation in preclinical studies. This …