Andrew S. Hanzlicek
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View article: Histoplasma capsulatum seroprevalence in free-roaming cats from 2 endemic regions
Histoplasma capsulatum seroprevalence in free-roaming cats from 2 endemic regions Open
Objective The aim of this study was to investigate Histoplasma seroprevalence and associated risk factors in free-roaming cats from 2 endemic regions: north central Oklahoma and eastern Tennessee. Methods Seroprevalence was determined usin…
View article: The 4 prokinetic drugs metoclopramide, cisapride, pyridostigmine, and capromorelin do not increase fecal output or food intake in healthy New Zealand rabbits (Oryctolagus cuniculus)
The 4 prokinetic drugs metoclopramide, cisapride, pyridostigmine, and capromorelin do not increase fecal output or food intake in healthy New Zealand rabbits (Oryctolagus cuniculus) Open
Objective To determine the effects of drugs with potential prokinetic effect through different mechanisms of action (metoclopramide, cisapride, pyridostigmine, and capromorelin) on food consumption, fecal production, water intake, and urin…
View article: P-2142. Cross-Reactivity of Fungal Enzyme Immunoassays (EIA): Implications for Clinical Diagnosis in Patients with Autoimmune Disease
P-2142. Cross-Reactivity of Fungal Enzyme Immunoassays (EIA): Implications for Clinical Diagnosis in Patients with Autoimmune Disease Open
Background The immune system exhibits remarkable discriminatory power, distinguishing between self and non-self to mount protective responses against infections. In clinical diagnostics targeting dimorphic fungi, this immunological discrim…
View article: Human and Canine Blastomycosis Cases Associated with Riverside Neighborhood, Wisconsin, USA, December 2021–March 20221
Human and Canine Blastomycosis Cases Associated with Riverside Neighborhood, Wisconsin, USA, December 2021–March 20221 Open
We investigated a blastomycosis cluster among humans and canines in a neighborhood in Wisconsin, United States. We conducted interviews and collected serum specimens for Blastomyces antibody testing by enzyme immunoassay. Although no defin…
View article: Pharmacokinetics of isavuconazonium sulfate and its active metabolite isavuconazole in healthy dogs
Pharmacokinetics of isavuconazonium sulfate and its active metabolite isavuconazole in healthy dogs Open
Invasive fungal infections (IFIs) are growing in importance in veterinary and human medicine. IFIs such as aspergillosis, blastomycosis, coccidioidomycosis and histoplasmosis remain challenging to treat in dogs. Isavuconazole is a novel an…
View article: Serial evaluation of liver enzyme activities in dogs with pulmonary coccidioidomycosis administered per os fluconazole
Serial evaluation of liver enzyme activities in dogs with pulmonary coccidioidomycosis administered per os fluconazole Open
Pulmonary coccidioidomycosis is a relatively common fungal disorder in dogs that have lived in or traveled to endemic regions and fluconazole is a common antifungal treatment. Liver enzymopathy can occur with fluconazole administration, bu…
View article: Serum C-reactive protein and haptoglobin decrease in the first three months of treatment and relative change in haptoglobin predict remission in dogs with pulmonary coccidioidomycosis
Serum C-reactive protein and haptoglobin decrease in the first three months of treatment and relative change in haptoglobin predict remission in dogs with pulmonary coccidioidomycosis Open
OBJECTIVE To evaluate temporal changes in serum C-reactive protein (CRP) and haptoglobin (Hp) concentrations in dogs with pulmonary coccidioidomycosis and assess their utility to detect remission. METHODS 31 client-owned dogs with newly di…
View article: A commercial whole blood polymerase chain reaction assay failed to diagnose histoplasmosis in cats confirmed by cytology or urine antigen detection
A commercial whole blood polymerase chain reaction assay failed to diagnose histoplasmosis in cats confirmed by cytology or urine antigen detection Open
OBJECTIVE To determine the sensitivity and specificity of a commercial whole blood real-time PCR assay (RT-PCR) for the diagnosis of histoplasmosis when compared to direct organism identification and/or urine antigen quantification by enzy…
View article: Histoplasmosis in domestic cats: new minimally invasive diagnostic techniques
Histoplasmosis in domestic cats: new minimally invasive diagnostic techniques Open
Objectives The aim of the present study was to evaluate minimally invasive diagnostic techniques, such as the semi-quantitative indirect IgG antibody enzyme immunoassay (EIA) using blood serum and the urinary lateral flow assay (LFA), for …
View article: <scp>ACVIM</scp> consensus statement on the diagnosis of immune thrombocytopenia in dogs and cats
<span>ACVIM</span> consensus statement on the diagnosis of immune thrombocytopenia in dogs and cats Open
Immune thrombocytopenia (ITP) is the most common acquired primary hemostatic disorder in dogs. Immune thrombocytopenia less commonly affects cats but is an important cause of mortality and treatment‐associated morbidity in both species. Im…
View article: Tracing histoplasmosis genomic epidemiology and species occurrence across the USA
Tracing histoplasmosis genomic epidemiology and species occurrence across the USA Open
ABSTRACTHistoplasmosis is an endemic mycosis in North America frequently reported along the Ohio and Mississippi River Valleys, although autochthonous cases occur in non-endemic areas. In the United States, the disease is provoked b…
View article: A single injection of high-concentration buprenorphine significantly reduces food and water intake as well as fecal and urine production in New Zealand White rabbits (Oryctolagus cuniculus)
A single injection of high-concentration buprenorphine significantly reduces food and water intake as well as fecal and urine production in New Zealand White rabbits (Oryctolagus cuniculus) Open
OBJECTIVE To evaluate selected gastrointestinal side effects of high-concentration buprenorphine (HCB) in healthy rabbits. ANIMALS 10 healthy New Zealand White rabbits ranging in body weight between 3.0 and 3.8 kg. METHODS Eight, 6-month-o…
View article: 609. Development of an Aspergillus Antigen Detection EIA
609. Development of an Aspergillus Antigen Detection EIA Open
Background Aspergillosis is a mycosis caused by Aspergillus spp. Invasive infections are often life threatening in individuals with weakened immune systems. Detection of Aspergillus galactomannan by enzyme immunoassay (EIA) is the method u…
View article: Evaluation of an enzyme immunoassay and immunodiffusion for detection of<scp>anti‐<i>Histoplasma</i></scp>antibodies in serum from cats and dogs
Evaluation of an enzyme immunoassay and immunodiffusion for detection of<span>anti‐<i>Histoplasma</i></span>antibodies in serum from cats and dogs Open
Background Histoplasma antigen and anti‐ Histoplasma antibody detection are used to support the diagnosis of histoplasmosis. There is a paucity of published data on antibody assays. Objectives Our primary hypothesis was that anti‐ Histopla…
View article: Clinical utility of fungal culture and antifungal susceptibility in cats and dogs with histoplasmosis
Clinical utility of fungal culture and antifungal susceptibility in cats and dogs with histoplasmosis Open
Background Culture can be used for diagnosis and antifungal susceptibility testing in animals with fungal infections. Limited information is available regarding the diagnostic performance of culture and the susceptibility patterns of Histo…
View article: Evaluation of serum 25‐hydroxyvitamin D, C‐reactive protein, and haptoglobin as biomarkers in dogs newly diagnosed with histoplasmosis
Evaluation of serum 25‐hydroxyvitamin D, C‐reactive protein, and haptoglobin as biomarkers in dogs newly diagnosed with histoplasmosis Open
Background Serum 25‐hydroxyvitamin (OH)D, C‐reactive protein (CRP), and haptoglobin are useful biomarkers in various infectious diseases and inflammatory disorders in dogs, but their utility in histoplasmosis is unknown. Objective Determin…
View article: Clinical utility of an immunoglobulin A‐based serological panel for the diagnosis of chronic enteropathy in dogs
Clinical utility of an immunoglobulin A‐based serological panel for the diagnosis of chronic enteropathy in dogs Open
Background A panel of IgA‐based serologic assays might aid in the diagnosis of chronic enteropathy (CE) in dogs, a syndrome encompassing conditions such as food‐responsive enteropathy, immunosuppressant‐responsive enteropathy, and inflamma…
View article: Prevalence of ocular lesions in cats newly diagnosed with histoplasmosis: 55 cases (2015–2022)
Prevalence of ocular lesions in cats newly diagnosed with histoplasmosis: 55 cases (2015–2022) Open
OBJECTIVE To describe the prevalence of ocular lesions in cats with newly diagnosed histoplasmosis. ANIMALS 55 client-owned domestic cats. PROCEDURES As part of this prospective case series, cats diagnosed with histoplasmosis between the y…
View article: In vitro effect of hydroxyethyl starch on coagulation in dogs as assessed by dynamic viscoelastic coagulometry
In vitro effect of hydroxyethyl starch on coagulation in dogs as assessed by dynamic viscoelastic coagulometry Open
OBJECTIVE To evaluate the effect of 6% hydroxyethyl starch (HES) 670/0.75 and 6% HES 130/0.4 dilution of canine whole blood on coagulation using dynamic viscoelastic coagulometry (DVC). ANIMALS 56 healthy adult dogs. PROCEDURES 2 blood sam…
View article: Invasive fungal rhinitis with adnexal involvement caused by <i>Histoplasma capsulatum</i> in a cat from a non-enzootic location
Invasive fungal rhinitis with adnexal involvement caused by <i>Histoplasma capsulatum</i> in a cat from a non-enzootic location Open
Case summary This report describes a cat with a rare form of histoplasmosis: invasive rhinitis with adnexal involvement, mimicking disease more commonly caused by cryptococcosis or aspergillosis. This case is especially noteworthy as it wa…
View article: Evaluation of a novel monoclonal antibody‐based enzyme immunoassay for detection of <i>Histoplasma</i> antigen in urine of dogs
Evaluation of a novel monoclonal antibody‐based enzyme immunoassay for detection of <i>Histoplasma</i> antigen in urine of dogs Open
Background Commercially available, noninvasive testing options for histoplasmosis are limited outside of the United States. Objectives To describe the diagnostic performance of a novel Histoplasma antigen enzyme immunoassay (IM EIA) for th…
View article: Effect of rest temperature on rotational thromboelastometry in New Zealand White rabbits
Effect of rest temperature on rotational thromboelastometry in New Zealand White rabbits Open
With the increasing popularity of viscoelastic coagulation analyzers, such as rotational thromboelastometry [ROTEM] and thromboelastography, the need for standardized methodology for appropriate interpretation has become increasingly impor…
View article: A monoclonal antibody‐based urine <i>Histoplasma</i> antigen enzyme immunoassay (IMMY®) for the diagnosis of histoplasmosis in cats
A monoclonal antibody‐based urine <i>Histoplasma</i> antigen enzyme immunoassay (IMMY®) for the diagnosis of histoplasmosis in cats Open
Background An in‐house Histoplasma urine antigen test for cats might be desirable in certain situations. Objective To validate and compare the diagnostic performance of a monoclonal antibody‐based IMMY urine Histoplasma antigen enzyme immu…
View article: Feline histoplasmosis presenting with bone and joint involvement: clinical and diagnostic findings in 25 cats
Feline histoplasmosis presenting with bone and joint involvement: clinical and diagnostic findings in 25 cats Open
Objectives The aim of this study was to describe clinical and diagnostic findings in cats with bone and joint disease associated with histoplasmosis. Methods Medical records from between 2011 and 2017 were reviewed. Inclusion criteria requ…
View article: Pretreatment <i>Histoplasma capsulatum</i> urine enzymatic immunoassay concentrations do not correlate with outcome but may be influenced by renal function in cats with histoplasmosis
Pretreatment <i>Histoplasma capsulatum</i> urine enzymatic immunoassay concentrations do not correlate with outcome but may be influenced by renal function in cats with histoplasmosis Open
Objectives The objective of this study was to determine if urine Histoplasma antigen (HAg) enzyme immunoassay (EIA) concentrations at the time of diagnosis and prior to the administration of antifungal agents are predictive of outcome for …
View article: Candidate prognostic indicators in cats with histoplasmosis treated with antifungal therapy
Candidate prognostic indicators in cats with histoplasmosis treated with antifungal therapy Open
Objectives The aim of this study was to retrospectively identify candidate prognostic indicators in cats with histoplasmosis treated with antifungal therapy. Methods Medical records of cats diagnosed with histoplasmosis were reviewed. Cand…
View article: Reduced susceptibility to fluconazole in a cat with histoplasmosis
Reduced susceptibility to fluconazole in a cat with histoplasmosis Open
Case summary An 11-year-old neutered male domestic longhair cat was diagnosed with histoplasmosis from fine-needle aspirates of an abdominal lymph node. Lymph node size initially decreased with fluconazole therapy (11.8 mg/kg PO q12h); how…
View article: Antigen Concentrations as an Indicator of Clinical Remission and Disease Relapse in Cats with Histoplasmosis
Antigen Concentrations as an Indicator of Clinical Remission and Disease Relapse in Cats with Histoplasmosis Open
Background Treatment monitoring is subjective and disease relapse is common in cats with histoplasmosis. The Histoplasma antigen enzyme immunoassay ( EIA ) is a noninvasive test used for determining disease remission and detecting disease …
View article: Antigenemia without antigenuria in a cat with histoplasmosis
Antigenemia without antigenuria in a cat with histoplasmosis Open
Case summary Based on demonstration of the yeast phase of Histoplasma capsulatum on fine-needle aspirate cytology of the kidney, a 5-year-old cat was diagnosed with histoplasmosis. Urine and serum were tested for antigen via a Histoplasma …