Andrew S. Little
YOU?
Author Swipe
View article: SUN-056 The National Biorepository and Resource for Pituitary Neuroendocrine Tumor Translational Research (BioPitNeT)
SUN-056 The National Biorepository and Resource for Pituitary Neuroendocrine Tumor Translational Research (BioPitNeT) Open
Disclosure: Y. Zavros: None. A.S. Little: None. S. Santagata: None. J.M. Wells: None. C. Mayhew: None. A.H. Kim: None. G. Zada: None. J. Chakrabarti: None. J.M. Eschbacher: None. K.C. Yuen: None. J.J. Evans: None. D.R. Pacione: None. R. Pa…
View article: Short-term Surgical Outcomes of Papillary Craniopharyngiomas: A Multicenter Study
Short-term Surgical Outcomes of Papillary Craniopharyngiomas: A Multicenter Study Open
Purpose: Craniopharyngiomas are rare parasellar tumors, and papillary craniopharyngiomas (PCP) represent 8-20% of cases. We assessed surgical outcomes of these very rare tumors among patients treated in the last decade. Methods: Retrospect…
View article: Extracranial-intracranial bypass using a cephalic vein graft for iatrogenic internal carotid artery injury during functional endoscopic sinus surgery: illustrative case
Extracranial-intracranial bypass using a cephalic vein graft for iatrogenic internal carotid artery injury during functional endoscopic sinus surgery: illustrative case Open
BACKGROUND Injury to the internal carotid artery (ICA) during functional endoscopic sinus surgery is a rare but potentially fatal complication. Although treatment algorithms have been developed, guidelines for effectively managing iatrogen…
View article: SAT-075 Revealing the Heterogeneity and Behavior of Pituitary Neuroendocrine Tumors in Cushing’s Disease Patients using Spatial Multiomics
SAT-075 Revealing the Heterogeneity and Behavior of Pituitary Neuroendocrine Tumors in Cushing’s Disease Patients using Spatial Multiomics Open
J. Chakrabarti: None. N.E. Garrett: None. K. Hurth: None. J.D. Carmichael: None. M. Shiroishi: None. D. Weisenberger: None. E.R. Laws: None. C. Horbinski: None. A.B. Castro: None. J. Eschbacher: None. A.S. Little: None. Y. Zavros: None. G.…
View article: 7399 Validation of Cushing’s Diagnostic Scoring Systems in a Multicenter US Based Population
7399 Validation of Cushing’s Diagnostic Scoring Systems in a Multicenter US Based Population Open
Disclosure: S. Mehta: None. K.L. Havranek: None. D. Pacione: None. K. Yuen: Advisory Board Member; Self; Corcept, Recordati, Xeris. Consulting Fee; Self; Novo Nordisk, Ipsen, Amryt Pharma, Crinetics Pharmaceuticals, Recordati, Xeris Biopha…
View article: Improving heart rate monitoring in the obese with time-of-flight photoplethysmography (TOF-PPG): a quantitative analysis of source-detector-distance effect
Improving heart rate monitoring in the obese with time-of-flight photoplethysmography (TOF-PPG): a quantitative analysis of source-detector-distance effect Open
Commercial photoplethysmography (PPG) sensors rely on the measurement of continuous-wave diffuse reflection signals (CW-DRS) to monitor heart rate. Using Monte Carlo modeling of light propagation in skin, we quantitatively evaluate the dep…
View article: Clinical Implications of Pituitary Adenomas Exhibiting Dual Transcription Factor Staining: A Case Series of 27 Patients
Clinical Implications of Pituitary Adenomas Exhibiting Dual Transcription Factor Staining: A Case Series of 27 Patients Open
View article: SAT625 The EGF-TBX19-EGFR Positive Feedback Loop Regulates The Expression Of The CD44v9/SLC7A11 Antioxidant System Within Corticotroph Pituitary Neuroendocrine Tumors
SAT625 The EGF-TBX19-EGFR Positive Feedback Loop Regulates The Expression Of The CD44v9/SLC7A11 Antioxidant System Within Corticotroph Pituitary Neuroendocrine Tumors Open
Disclosure: J. Chakrabarti: None. J. Eschbacher: None. K. Yuen: None. A.S. Little: None. Y. Zavros: None. Background: Stereotactic radiosurgery is a therapeutic modality considered in the adjuvant setting of patients with failed transsphen…
View article: OR20-05 Generation Of CDH23-mutated Pituitary Neuroendocrine Tumor Organoids From Induced Pluripotent Stem Cells To Model Cushing’s Disease Pathogenesis
OR20-05 Generation Of CDH23-mutated Pituitary Neuroendocrine Tumor Organoids From Induced Pluripotent Stem Cells To Model Cushing’s Disease Pathogenesis Open
Disclosure: J. Chakrabarti: None. S. Mallick: None. J. Churko: None. J. Eschbacher: None. A.S. Little: None. K.C. Yuen: None. Y. Zavros: None. Background: Cushing's disease (CD) is a debilitating disease caused by an adrenocorticotropic ho…
View article: THU077 Differences In Clinicopathological Features Of Acidophil Stem Cell Adenomas Compared To Other Subtypes Of Acromegaly: A Retrospective Study
THU077 Differences In Clinicopathological Features Of Acidophil Stem Cell Adenomas Compared To Other Subtypes Of Acromegaly: A Retrospective Study Open
Disclosure: K.C. Yuen: Advisory Board Member; Self; Novo Nordisk, Ascendis, Corcept Therapeutics, Ipsen, Amryt, Strongbridge, Crinetics, Recordati, Xeris. Grant Recipient; Self; Corcept Therapeutics, Crinetics, Ascendis, Amryt. Speaker; Se…
View article: Genetically engineered human pituitary corticotroph tumor organoids exhibit divergent responses to glucocorticoid receptor modulators
Genetically engineered human pituitary corticotroph tumor organoids exhibit divergent responses to glucocorticoid receptor modulators Open
View article: A Prospective Comparative Analysis of Surgical Versus Non-Surgical Management of Pituitary Apoplexy: Analysis of The  Pituitary Apoplexy Surgical Treatment and Outcomes Registry (PASTOR)
A Prospective Comparative Analysis of Surgical Versus Non-Surgical Management of Pituitary Apoplexy: Analysis of The Pituitary Apoplexy Surgical Treatment and Outcomes Registry (PASTOR) Open
View article: The RAPID Consortium: A Platform for Clinical and Translational Pituitary Tumor Research
The RAPID Consortium: A Platform for Clinical and Translational Pituitary Tumor Research Open
Objectives Pituitary tumor treatment is hampered by the relative rarity of the disease, absence of a multicenter collaborative platform, and limited translational–clinical research partnerships. Prior studies offer limited insight into the…
View article: RF01 | PMON168 Hedgehog-Induced Somatostatin Receptor Expression is Inhibited by the Activation of the Glucocorticoid Receptor Signaling Pathway in Human Pituitary Adenoma Organoids
RF01 | PMON168 Hedgehog-Induced Somatostatin Receptor Expression is Inhibited by the Activation of the Glucocorticoid Receptor Signaling Pathway in Human Pituitary Adenoma Organoids Open
Background Cushing's disease (CD) is an endocrine disorder caused by an ACTH-secreting pituitary adenoma that is associated with increased morbidity and mortality. Because somatostatin inhibits pituitary ACTH secretion, the somatostatin re…
View article: Development of Human Pituitary Neuroendocrine Tumor Organoids to Facilitate Effective Targeted Treatments of Cushing’s Disease
Development of Human Pituitary Neuroendocrine Tumor Organoids to Facilitate Effective Targeted Treatments of Cushing’s Disease Open
(1) Background: Cushing’s disease (CD) is a serious endocrine disorder caused by an adrenocorticotropic hormone (ACTH)-secreting pituitary neuroendocrine tumor (PitNET) that stimulates the adrenal glands to overproduce cortisol. Chronic ex…
View article: Twisting Ovaries: Three Cases of Ovarian Torsion
Twisting Ovaries: Three Cases of Ovarian Torsion Open
View article: Genetically Engineered Human Pituitary Corticotroph Tumor Organoids Exhibit Divergent Responses To Glucocorticoid Receptor Modulators
Genetically Engineered Human Pituitary Corticotroph Tumor Organoids Exhibit Divergent Responses To Glucocorticoid Receptor Modulators Open
Cushing’s disease (CD) is a serious endocrine disorder attributed to an ACTH-secreting pituitary neuroendocrine tumor (PitNET) that subsequently causes chronic hypercortisolemia. PitNET regression has been reported following treatment with…
View article: Intraoperative confocal laser endomicroscopy: prospective in vivo feasibility study of a clinical-grade system for brain tumors
Intraoperative confocal laser endomicroscopy: prospective in vivo feasibility study of a clinical-grade system for brain tumors Open
OBJECTIVE The authors evaluated the feasibility of using the first clinical-grade confocal laser endomicroscopy (CLE) system using fluorescein sodium for intraoperative in vivo imaging of brain tumors. METHODS A CLE system cleared by the F…
View article: Unique Presentation and Novel Surgical Approach to a Transcribriform Penetrating Head Injury Caused by a Nail Gun
Unique Presentation and Novel Surgical Approach to a Transcribriform Penetrating Head Injury Caused by a Nail Gun Open
A penetrating head injury caused by a nail gun is an infrequent clinically diverse condition that varies in severity by the neurovascular structures involved. The authors present the case of a patient whose frontal lobe was pierced by a na…
View article: Real-time intraoperative surgical telepathology using confocal laser endomicroscopy
Real-time intraoperative surgical telepathology using confocal laser endomicroscopy Open
OBJECTIVE Communication between neurosurgeons and pathologists is mandatory for intraoperative decision-making and optimization of resection, especially for invasive masses. Handheld confocal laser endomicroscopy (CLE) technology provides …
View article: Provider Perspective on Being Recorded During Emergency Medicine Discharge Conversations
Provider Perspective on Being Recorded During Emergency Medicine Discharge Conversations Open
View article: Cost-Effective Training Models in Point-of-Care Ultrasound for Medical Students in Emergency Medicine: An Evaluation of Current Resources
Cost-Effective Training Models in Point-of-Care Ultrasound for Medical Students in Emergency Medicine: An Evaluation of Current Resources Open
View article: Changing face of training in light of the COVID-19 pandemic: trainee survey reflections
Changing face of training in light of the COVID-19 pandemic: trainee survey reflections Open
View article: O-18 A qualitative exploration of advance care planning in patients with home NIV for COPD
O-18 A qualitative exploration of advance care planning in patients with home NIV for COPD Open
Background The HOT-HMV study in 2017 demonstrated that patients with persistent hypercapnia following an exacerbation of chronic obstructive pulmonary disease (COPD) who received home non-invasive ventilation (NIV) benefitted from prolonge…
View article: P-40 The changing face of training in light of the COVID-19 pandemic
P-40 The changing face of training in light of the COVID-19 pandemic Open
Background The Covid-19 pandemic brought many changes to palliative care. Services had to rapidly adapt to provide the structures needed in challenging and evolving conditions. Service workforces contained palliative medicine trainees who,…
View article: Comparative Analysis of Surgical Exposure among Endoscopic Endonasal Approaches to Petrosectomy: An Experimental Study in Cadavers
Comparative Analysis of Surgical Exposure among Endoscopic Endonasal Approaches to Petrosectomy: An Experimental Study in Cadavers Open
Objectives Endoscopic endonasal approaches (EEAs) for petrosectomies are evolving to reduce perioperative brain injuries and complications. Surgical terminology, techniques, landmarks, advantages, and limitations of these approaches remain…
View article: Perioperative Complication Profile of Skull Base Meningioma Resection in Older versus Younger Adult Patients
Perioperative Complication Profile of Skull Base Meningioma Resection in Older versus Younger Adult Patients Open
Objectives To better understand the risk-benefit profile of skull base meningioma resection in older patients, we compared perioperative complications among older and younger patients. Design Present study is based on retrospective outcome…
View article: Residual Tumor Volume and Tumor Progression after Subtotal Resection and Observation of WHO Grade I Skull Base Meningiomas
Residual Tumor Volume and Tumor Progression after Subtotal Resection and Observation of WHO Grade I Skull Base Meningiomas Open
Objective This study investigated the impact of residual tumor volume (RTV) on tumor progression after subtotal resection and observation of WHO grade I skull base meningiomas. Study Design This study is a retrospective volumetric analysis…
View article: Postoperative 30-day emergency department utilization after 7294 cranial neurosurgery procedures at a tertiary neuroscience center
Postoperative 30-day emergency department utilization after 7294 cranial neurosurgery procedures at a tertiary neuroscience center Open
OBJECTIVE Hospital readmission and the reduction thereof has become a major quality improvement initiative in organized medicine and neurosurgery. However, little research has been performed on why neurosurgical patients utilize hospital e…
View article: Confocal Laser Endomicroscopy Assessment of Pituitary Tumor Microstructure: A Feasibility Study
Confocal Laser Endomicroscopy Assessment of Pituitary Tumor Microstructure: A Feasibility Study Open
This is the first study to assess confocal laser endomicroscopy (CLE) use within the transsphenoidal approach and show the feasibility of obtaining digital diagnostic biopsies of pituitary tumor tissue after intravenous fluorescein injecti…