Explanipedia

IL-25-induced memory type 2 innate lymphoid cells enforce mucosal immunity Open

Victor S. Cortez, Sara Viragova, Satoshi Koga, Meizi Liu, Claire E. O’Leary , et al. · 2025

Adaptation of intestinal helminths to vertebrates involved the evolution of strategies to attenuate host tissue damage to support parasite reproduction and dissemination of offspring to the environment. Helminths initiate the IL-25-mediate…

How Increasing Research Demands Threaten Equity in Dermatology Residency Selection and Strategies for Reform Open

Charlotte McRae, Andrew Schroeder, Michael P. Anderson, Laci Turner, Lauren Kole · 2025

The shift in United States Medical Licensing Examination (USMLE) Step 1 scoring to pass/fail has intensified the emphasis on research productivity in dermatology residency applications. Through a cross-sectional survey, we examined barrier…

Lichen planus onset during interleukin 23 blockade for treatment of psoriasis Open

Alia Abbas, Andrew Schroeder, Carly Elston, Chander Raman, Boni E. Elewski · 2025

IL-25-induced memory ILC2s mediate long-term small intestinal adaptation Open

Victor S. Cortez, Sara Viragova, S Koga, Meizi Liu, Claire E. O’Leary , et al. · 2025

SUMMARY The adaptation of intestinal helminths to vertebrates evolved strategies to attenuate host tissue damage to support reproductive needs of parasites necessary to disseminate offspring to the environment. Helminths initiate the IL-25…

Microbial dynamics and pulmonary immune responses in COVID-19 secondary bacterial pneumonia Open

Natasha Spottiswoode, Alexandra Tsitsiklis, Victoria Chu, Hoang Van Phan, Catherine DeVoe , et al. · 2024

Secondary bacterial pneumonia (2°BP) is associated with significant morbidity following respiratory viral infection, yet remains incompletely understood. In a prospective cohort of 112 critically ill adults intubated for COVID-19, we compa…

IL-31–dependent neurogenic inflammation restrains cutaneous type 2 immune response in allergic dermatitis Open

Marlys S. Fassett, João M. Bráz, Carlos A. Castellanos, Juan J. Salvatierra, Mahsa Sadeghi , et al. · 2023

Despite robust literature associating IL-31 with pruritic inflammatory skin diseases, its influence on cutaneous inflammation and the interplay between inflammatory and neurosensory pathways remain unmapped. Here, we examined the consequen…

A myeloid program associated with COVID-19 severity is decreased by therapeutic blockade of IL-6 signaling Open

Jason A. Hackney, Haridha Shivram, Jason A. Vander Heiden, Christopher C. Overall, Luz D. Orozco , et al. · 2023

Altered myeloid inflammation and lymphopenia are hallmarks of severe infections. We identified the upregulated EN-RAGE gene program in airway and blood myeloid cells from patients with acute lung injury from SARS-CoV-2 or other causes acro…

Multi-omic longitudinal study reveals immune correlates of clinical course among hospitalized COVID-19 patients Open

Joann Diray‐Arce, Slim Fourati, Naresh Doni Jayavelu, Ravi K. Patel, Cole Maguire , et al. · 2023

The IMPACC cohort, composed of >1,000 hospitalized COVID-19 participants, contains five illness trajectory groups (TGs) during acute infection (first 28 days), ranging from milder (TG1-3) to more severe disease course (TG4) and death (TG5)…

An essential role for miR-15/16 in Treg suppression and restriction of proliferation Open

Kristina Johansson, John D Gagnon, Simon K. Zhou, Marlys S. Fassett, Andrew Schroeder , et al. · 2023

The miR-15/16 family is a highly expressed group of tumor suppressor miRNAs that target a large network of genes in T cells to restrict their cell cycle, memory formation and survival. Upon T cell activation, miR-15/16 are downregulated, a…

An Essential Role for miR-15/16 in Treg Suppression and Restriction of Proliferation Open

Kristina Johansson, John D Gagnon, Simon K. Zhou, Marlys S. Fassett, Andrew Schroeder , et al. · 2023

Innate type 2 immunity controls hair follicle commensalism by Demodex mites Open

Roberto R. Ricardo-González, Maya E. Kotas, Claire E. O’Leary, Katelyn Singh, William Damsky , et al. · 2022

A functional circuit formed by the autonomic nerves and myofibroblasts controls mammalian alveolar formation for gas exchange Open

Kuan Zhang, Erica Yao, Shao‐An Wang, Ethan Chuang, Julia Wong , et al. · 2022

Bile acid–sensitive tuft cells regulate biliary neutrophil influx Open

Claire E. O’Leary, Julia Sbierski‐Kind, Maya E. Kotas, Johanna Wagner, Hong-Erh Liang , et al. · 2022

Inflammation and dysfunction of the extrahepatic biliary tree are common causes of human pathology, including gallstones and cholangiocarcinoma. Despite this, we know little about the local regulation of biliary inflammation. Tuft cells, r…

Innate Type 2 Immunity Controls Hair Follicle Commensalism by <i>Demodex</i> Mites Open

Roberto R. Ricardo-González, Maya E. Kotas, Claire E. O’Leary, Iliana Tenvooren, Diana M. Marquez , et al. · 2022

Lymph node–resident dendritic cells drive T <sub>H</sub> 2 cell development involving MARCH1 Open

Carlos A. Castellanos, Xin Ren, Steven Lomeli Gonzalez, Hong Kun Li, Andrew Schroeder , et al. · 2021

Type 2 immune development depends on MARCH1-mediated turnover of MHCII and CD86 by lymph node–resident dendritic cells.

CISH constrains the tuft–ILC2 circuit to set epithelial and immune tone Open

Maya E. Kotas, Nicholas M. Mroz, Satoshi Koga, Hong-Erh Liang, Andrew Schroeder , et al. · 2021

Corrigendum: Near-Single-Cell Proteomics Profiling of the Proximal Tubular and Glomerulus of the Normal Human Kidney Open

Tara K. Sigdel, Paul Piehowski, Sudeshna Roy, Juliane Liberto, Joshua Hansen , et al. · 2021

[This corrects the article DOI: 10.3389/fmed.2020.00499.].

Large-scale, three-dimensional tissue cytometry of the human kidney: a complete and accessible pipeline Open

Michael J. Ferkowicz, Seth Winfree, Angela R. Sabo, Malgorzata M. Kamocka, Suraj Khochare , et al. · 2021

Near-Single-Cell Proteomics Profiling of the Proximal Tubular and Glomerulus of the Normal Human Kidney Open

Tara K. Sigdel, Paul Piehowski, Sudeshna Roy, Juliane Liberto, Joshua Hansen , et al. · 2020

Molecular assessments at the single cell level can accelerate biological research by providing detailed assessments of cellular organization and tissue heterogeneity in both disease and health. The human kidney has complex multi-cellular s…

Targeted Urine Metabolomics for Monitoring Renal Allograft Injury and Immunosuppression in Pediatric Patients Open

Tara K. Sigdel, Andrew Schroeder, Joshua Yang, Reuben D. Sarwal, Juliane Liberto , et al. · 2020

Despite new advancements in surgical tools and therapies, exposure to immunosuppressive drugs related to non-immune and immune injuries can cause slow deterioration and premature failure of organ transplants. Diagnosis of these injuries by…

Novel Human Kidney Cell Subsets Identified by Mux-Seq Open

Andrew Schroeder, Swastika Sur, Priyanka Rashmi, Izabella Damm, Arya Zarinsefat , et al. · 2020

Background The kidney is a highly complex organ that performs multiple functions necessary to maintain systemic homeostasis, with complex interplay from different kidney sub-structures and the coordinated response of diverse cell types, fe…

Corrigendum to ‘Society of Cardiovascular Anesthesiologists (SCA) Clinical Practice Improvement (CPI) Advisory for Management of Perioperative Bleeding and Hemostasis in Cardiac Surgery Patients’ [Journal of Cardiothoracic and Vascular Anesthesia 33 (2019) 2887-2899] Open

Jacob Raphael, C. David Mazer, Andrew Wilkey, Sudhakar Subramani, Andrew Schroeder , et al. · 2019

Articles to Appear in Future Issues Open

Giovanni Cianchi, Chiara Lazzeri, Manuela Bonizzoli, Stefano Batacchi, Gabriella Di Lascio , et al. · 2019

A urinary Common Rejection Module (uCRM) score for non-invasive kidney transplant monitoring Open

Tara K. Sigdel, Joshua Yang, Oriol Bestard, Andrew Schroeder, Szu‐Chuan Hsieh , et al. · 2019

A Common Rejection Module (CRM) consisting of 11 genes expressed in allograft biopsies was previously reported to serve as a biomarker for acute rejection (AR), correlate with the extent of graft injury, and predict future allograft damage…

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