Michael A. Silver
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View article: A novel method for quantitative analysis of subjective experience reports: application to psychedelic visual experiences
A novel method for quantitative analysis of subjective experience reports: application to psychedelic visual experiences Open
Introduction Psychedelic compounds such as LSD, psilocybin, mescaline, and DMT can dramatically alter visual perception. However, the extent to which visual effects of psychedelics consistently vary for different substances is an open ques…
View article: A randomized double-blind placebo-controlled clinical trial of Guanfacine Extended Release for aggression and self-injurious behavior associated with Prader-Willi Syndrome
A randomized double-blind placebo-controlled clinical trial of Guanfacine Extended Release for aggression and self-injurious behavior associated with Prader-Willi Syndrome Open
Introduction: Prader-Willi Syndrome (PWS), a rare genetic disorder, affects development and behavior, frequently resulting in self-injury, aggression, hyperphagia, oppositional behavior, impulsivity and over-activity causing significant mo…
View article: Top-Down Priors Disambiguate Target and Distractor Features in Simulated Covert Visual Search
Top-Down Priors Disambiguate Target and Distractor Features in Simulated Covert Visual Search Open
Several models of visual search consider visual attention as part of a perceptual inference process, in which top-down priors disambiguate bottom-up sensory information. Many of these models have focused on gaze behavior, but there are rel…
View article: Enhanced perceptual selection of predicted stimulus orientations following statistical learning
Enhanced perceptual selection of predicted stimulus orientations following statistical learning Open
Perception is influenced by predictions about the sensory environment. These predictions are informed by past experience and can be shaped by exposure to recurring patterns of sensory stimulation. Predictions can enhance perception of a pr…
View article: Data from A Noninvasive Blood-based Combinatorial Proteomic Biomarker Assay to Detect Breast Cancer in Women over age 50 with BI-RADS 3, 4, or 5 Assessment
Data from A Noninvasive Blood-based Combinatorial Proteomic Biomarker Assay to Detect Breast Cancer in Women over age 50 with BI-RADS 3, 4, or 5 Assessment Open
Purpose:With improvements in breast cancer imaging, there has been a corresponding increase in false-positives and avoidable biopsies. There is a need to better differentiate when a breast biopsy is warranted and determine appropriate foll…
View article: Data from A Noninvasive Blood-based Combinatorial Proteomic Biomarker Assay to Detect Breast Cancer in Women over age 50 with BI-RADS 3, 4, or 5 Assessment
Data from A Noninvasive Blood-based Combinatorial Proteomic Biomarker Assay to Detect Breast Cancer in Women over age 50 with BI-RADS 3, 4, or 5 Assessment Open
Purpose:With improvements in breast cancer imaging, there has been a corresponding increase in false-positives and avoidable biopsies. There is a need to better differentiate when a breast biopsy is warranted and determine appropriate foll…
View article: Figure S5 from A Noninvasive Blood-based Combinatorial Proteomic Biomarker Assay to Detect Breast Cancer in Women over age 50 with BI-RADS 3, 4, or 5 Assessment
Figure S5 from A Noninvasive Blood-based Combinatorial Proteomic Biomarker Assay to Detect Breast Cancer in Women over age 50 with BI-RADS 3, 4, or 5 Assessment Open
Figure S5: Individual ROC curves for Videssa Breast model training and validation. Curves shown correspond to those in Fig. 2.
View article: Figure S3 from A Noninvasive Blood-based Combinatorial Proteomic Biomarker Assay to Detect Breast Cancer in Women over age 50 with BI-RADS 3, 4, or 5 Assessment
Figure S3 from A Noninvasive Blood-based Combinatorial Proteomic Biomarker Assay to Detect Breast Cancer in Women over age 50 with BI-RADS 3, 4, or 5 Assessment Open
Figure S3: Breakdown of subjects excluded in the Provista-002 trial. Reasons for exclusion shown in legend.
View article: Figure S5 from A Noninvasive Blood-based Combinatorial Proteomic Biomarker Assay to Detect Breast Cancer in Women over age 50 with BI-RADS 3, 4, or 5 Assessment
Figure S5 from A Noninvasive Blood-based Combinatorial Proteomic Biomarker Assay to Detect Breast Cancer in Women over age 50 with BI-RADS 3, 4, or 5 Assessment Open
Figure S5: Individual ROC curves for Videssa Breast model training and validation. Curves shown correspond to those in Fig. 2.
View article: Figure S3 from A Noninvasive Blood-based Combinatorial Proteomic Biomarker Assay to Detect Breast Cancer in Women over age 50 with BI-RADS 3, 4, or 5 Assessment
Figure S3 from A Noninvasive Blood-based Combinatorial Proteomic Biomarker Assay to Detect Breast Cancer in Women over age 50 with BI-RADS 3, 4, or 5 Assessment Open
Figure S3: Breakdown of subjects excluded in the Provista-002 trial. Reasons for exclusion shown in legend.
View article: Figure S4 from A Noninvasive Blood-based Combinatorial Proteomic Biomarker Assay to Detect Breast Cancer in Women over age 50 with BI-RADS 3, 4, or 5 Assessment
Figure S4 from A Noninvasive Blood-based Combinatorial Proteomic Biomarker Assay to Detect Breast Cancer in Women over age 50 with BI-RADS 3, 4, or 5 Assessment Open
Figure S4: ROC overlay demonstrating relationship between FSH values and menopause status. Separate curves were generated for pre (n=333) vs. post (n=317) and vs. post/peri (n=390). Subjects who had undergone hysterectomy were excluded in …
View article: Supplementary Tables from A Noninvasive Blood-based Combinatorial Proteomic Biomarker Assay to Detect Breast Cancer in Women over age 50 with BI-RADS 3, 4, or 5 Assessment
Supplementary Tables from A Noninvasive Blood-based Combinatorial Proteomic Biomarker Assay to Detect Breast Cancer in Women over age 50 with BI-RADS 3, 4, or 5 Assessment Open
Table S1. Enrollment Criteria Table S2. Enrollment Sites Table S3. Serum protein biomarkers (SPB) and tumor-associated autoantibodies (TAAb) evaluated in the current study. Table S4: Clinical conditions and criteria for inclusion. Table S5…
View article: Figure S2 from A Noninvasive Blood-based Combinatorial Proteomic Biomarker Assay to Detect Breast Cancer in Women over age 50 with BI-RADS 3, 4, or 5 Assessment
Figure S2 from A Noninvasive Blood-based Combinatorial Proteomic Biomarker Assay to Detect Breast Cancer in Women over age 50 with BI-RADS 3, 4, or 5 Assessment Open
Figure S2: Clinical management workflow with inclusion/exclusion criteria for the PDX-002 clinical trial. *Details on malignancy risk from D'Orsi et al.[3]
View article: Figure S4 from A Noninvasive Blood-based Combinatorial Proteomic Biomarker Assay to Detect Breast Cancer in Women over age 50 with BI-RADS 3, 4, or 5 Assessment
Figure S4 from A Noninvasive Blood-based Combinatorial Proteomic Biomarker Assay to Detect Breast Cancer in Women over age 50 with BI-RADS 3, 4, or 5 Assessment Open
Figure S4: ROC overlay demonstrating relationship between FSH values and menopause status. Separate curves were generated for pre (n=333) vs. post (n=317) and vs. post/peri (n=390). Subjects who had undergone hysterectomy were excluded in …
View article: Figure S1 from A Noninvasive Blood-based Combinatorial Proteomic Biomarker Assay to Detect Breast Cancer in Women over age 50 with BI-RADS 3, 4, or 5 Assessment
Figure S1 from A Noninvasive Blood-based Combinatorial Proteomic Biomarker Assay to Detect Breast Cancer in Women over age 50 with BI-RADS 3, 4, or 5 Assessment Open
Figure S1: Breakdown of imaging modalities used to enroll subjects in Provista-002. Some subjects underwent multiple imaging procedures prior to enrollment, these are noted in side boxes for screening mammogram and diagnostic mammogram.
View article: Figure S2 from A Noninvasive Blood-based Combinatorial Proteomic Biomarker Assay to Detect Breast Cancer in Women over age 50 with BI-RADS 3, 4, or 5 Assessment
Figure S2 from A Noninvasive Blood-based Combinatorial Proteomic Biomarker Assay to Detect Breast Cancer in Women over age 50 with BI-RADS 3, 4, or 5 Assessment Open
Figure S2: Clinical management workflow with inclusion/exclusion criteria for the PDX-002 clinical trial. *Details on malignancy risk from D'Orsi et al.[3]
View article: Supplementary Tables from A Noninvasive Blood-based Combinatorial Proteomic Biomarker Assay to Detect Breast Cancer in Women over age 50 with BI-RADS 3, 4, or 5 Assessment
Supplementary Tables from A Noninvasive Blood-based Combinatorial Proteomic Biomarker Assay to Detect Breast Cancer in Women over age 50 with BI-RADS 3, 4, or 5 Assessment Open
Table S1. Enrollment Criteria Table S2. Enrollment Sites Table S3. Serum protein biomarkers (SPB) and tumor-associated autoantibodies (TAAb) evaluated in the current study. Table S4: Clinical conditions and criteria for inclusion. Table S5…
View article: Figure S1 from A Noninvasive Blood-based Combinatorial Proteomic Biomarker Assay to Detect Breast Cancer in Women over age 50 with BI-RADS 3, 4, or 5 Assessment
Figure S1 from A Noninvasive Blood-based Combinatorial Proteomic Biomarker Assay to Detect Breast Cancer in Women over age 50 with BI-RADS 3, 4, or 5 Assessment Open
Figure S1: Breakdown of imaging modalities used to enroll subjects in Provista-002. Some subjects underwent multiple imaging procedures prior to enrollment, these are noted in side boxes for screening mammogram and diagnostic mammogram.
View article: Effects of involuntary and voluntary attention on critical spacing of visual crowding
Effects of involuntary and voluntary attention on critical spacing of visual crowding Open
Visual spatial attention can be allocated in two distinct ways: one that is voluntarily directed to behaviorally relevant locations in the world, and one that is involuntarily captured by salient external stimuli. Precueing spatial attenti…
View article: Visual cortical γ−aminobutyric acid and perceptual suppression in amblyopia
Visual cortical γ−aminobutyric acid and perceptual suppression in amblyopia Open
In amblyopia, abnormal visual experience during development leads to an enduring loss of visual acuity in adulthood. Physiological studies in animal models suggest that intracortical GABAergic inhibition may mediate visual deficits in ambl…
View article: Spatial Attention Enhances Crowded Stimulus Encoding Across Modeled Receptive Fields by Increasing Redundancy of Feature Representations
Spatial Attention Enhances Crowded Stimulus Encoding Across Modeled Receptive Fields by Increasing Redundancy of Feature Representations Open
Any visual system, biological or artificial, must make a trade-off between the number of units used to represent the visual environment and the spatial resolution of the sampling array. Humans and some other animals are able to allocate at…
View article: Transfer of Perceptual Learning From Local Stereopsis to Global Stereopsis in Adults With Amblyopia: A Preliminary Study
Transfer of Perceptual Learning From Local Stereopsis to Global Stereopsis in Adults With Amblyopia: A Preliminary Study Open
It has long been debated whether the analysis of global and local stereoscopic depth is performed by a single system or by separate systems. Global stereopsis requires the visual system to solve a complex binocular matching problem to obta…
View article: Mortality Data in Mechanically Ventilated COVID-19 patients admitted to ICU: A Retrospective Study in Brooklyn
Mortality Data in Mechanically Ventilated COVID-19 patients admitted to ICU: A Retrospective Study in Brooklyn Open
High mortality rates are predominant even in COVID-19 patients requiring minimal supportive therapy, with a short-coming of data on COVID-19 patients requiring mechanical ventilation.
View article: Spatial Attention within Dynamic Receptive Field Pooling Arrays: Implications for Visual Crowding and Convolutional Neural Networks
Spatial Attention within Dynamic Receptive Field Pooling Arrays: Implications for Visual Crowding and Convolutional Neural Networks Open
Any visual system – biological or artificial – has an inherent trade-off between the number of units used to represent the visual environment and the spatial resolution of the sampling array. The human visual system is able to locally allo…
View article: Visual cortical GABA and depth of amblyopia are negatively correlated
Visual cortical GABA and depth of amblyopia are negatively correlated Open
Amblyopia is a neurodevelopmental disorder that is characterized by reduced visual acuity, atypical binocular integration, and heightened perceptual suppression. Physiology studies in animal models suggest that intracortical GABAergic inhi…
View article: Exploring Connections Between Cosmos & Mind Through Six Interactive Art Installations in "As Above As Below"
Exploring Connections Between Cosmos & Mind Through Six Interactive Art Installations in "As Above As Below" Open
Are there parallels between the furthest reaches of our universe, and the foundations of thought, awareness, perception, and emotion? What are the connections between the webs and structures that define both? What are the differences? "As …
View article: Exploring Connections Between Cosmos & Mind Through Six Interactive Art Installations in "As Above As Below"
Exploring Connections Between Cosmos & Mind Through Six Interactive Art Installations in "As Above As Below" Open
Are there parallels between the furthest reaches of our universe, and the foundations of thought, awareness, perception, and emotion? What are the connections between the webs and structures that define both? What are the differences? "As …
View article: Transient cholinergic enhancement does not significantly affect either the magnitude or selectivity of perceptual learning of visual texture discrimination
Transient cholinergic enhancement does not significantly affect either the magnitude or selectivity of perceptual learning of visual texture discrimination Open
Perceptual learning (PL), often characterized by improvements in perceptual performance with training that are specific to the stimulus conditions used during training, exemplifies experience-dependent cortical plasticity. An improved unde…