Andrew Simmonds
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View article: Peroxisome inter-organelle cooperation in <i>Drosophila</i>
Peroxisome inter-organelle cooperation in <i>Drosophila</i> Open
Many cellular functions are compartmentalized within the optimized environments of organelles. However, processing or storage of metabolites from the same pathway can occur in multiple organelles. Thus, spatially separated organelles need …
View article: A chromatin remodelling SWI/SNF subunit, Snr1, regulates neural stem cell determination and differentiation
A chromatin remodelling SWI/SNF subunit, Snr1, regulates neural stem cell determination and differentiation Open
Coordinated spatio-temporal regulation of the determination and differentiation of neural stem cells is essential for brain development. Failure to integrate multiple factors leads to defective brain structures or tumour formation. Previou…
View article: Recruitment of Peroxin 14 to lipid droplets affects lipid storage in <i>Drosophila</i>
Recruitment of Peroxin 14 to lipid droplets affects lipid storage in <i>Drosophila</i> Open
Both peroxisomes and lipid droplets regulate cellular lipid homeostasis. Direct inter-organellar contacts as well as novel roles for proteins associated with peroxisome or lipid droplets occur when cells are induced to liberate fatty acids…
View article: Modulation of the cell membrane lipid milieu by peroxisomal β-oxidation induces Rho1 signaling to trigger inflammatory responses
Modulation of the cell membrane lipid milieu by peroxisomal β-oxidation induces Rho1 signaling to trigger inflammatory responses Open
Phagocytosis, signal transduction, and inflammatory responses require changes in lipid metabolism. Peroxisomes have key roles in fatty acid homeostasis and in regulating immune function. We find that Drosophila macrophages lacking peroxiso…
View article: The Nitric Oxide Donor, S-Nitrosoglutathione, Rescues Peroxisome Number and Activity Defects in PEX1G843D Mild Zellweger Syndrome Fibroblasts
The Nitric Oxide Donor, S-Nitrosoglutathione, Rescues Peroxisome Number and Activity Defects in PEX1G843D Mild Zellweger Syndrome Fibroblasts Open
Peroxisome biogenesis disorders (PBDs) are a group of metabolic developmental diseases caused by mutations in one or more genes encoding peroxisomal proteins. Zellweger syndrome spectrum (PBD-ZSS) results from metabolic dysfunction caused …
View article: Effect of Celecoxib vs Placebo as Adjuvant Therapy on Disease-Free Survival Among Patients With Breast Cancer
Effect of Celecoxib vs Placebo as Adjuvant Therapy on Disease-Free Survival Among Patients With Breast Cancer Open
ClinicalTrials.gov Identifier: NCT02429427 and isrctn.org Identifier: ISRCTN48254013.
View article: Recruitment of Peroxin14 to lipid droplets affects triglyceride storage in Drosophila
Recruitment of Peroxin14 to lipid droplets affects triglyceride storage in Drosophila Open
The activity of multiple organelles must be coordinated to ensure cellular lipid homeostasis. This includes the peroxisomes which metabolise certain lipids and lipid droplets which act as neutral lipid storage centres. Direct organellar co…
View article: The monitoring of wall moisture in a property retrofitted with Internal Wall Insulation
The monitoring of wall moisture in a property retrofitted with Internal Wall Insulation Open
The purpose of this study was to measure the long-term moisture build-up in the walls of a house which had been retrofitted with Internal Wall Insulation.This was done by embedding moisture sensors in the walls and then monitoring values o…
View article: The monitoring of wall moisture in a property retrofitted with Internal Wall Insulation
The monitoring of wall moisture in a property retrofitted with Internal Wall Insulation Open
The purpose of this study was to measure the long-term moisture build-up in the walls of a house which had been retrofitted with Internal Wall Insulation. This was done by embedding moisture sensors in the walls and then monitoring values …
View article: Rosy Beginnings: Studying Peroxisomes in Drosophila
Rosy Beginnings: Studying Peroxisomes in Drosophila Open
Research using the fruit fly Drosophila melanogaster has traditionally focused on understanding how mutations affecting gene regulation or function affect processes linked to animal development. Accordingly, flies have become an essential …
View article: Impaired peroxisomal import in <i>Drosophila</i> hepatocyte-like cells induces cardiac dysfunction through the pro-inflammatory cytokine Upd3
Impaired peroxisomal import in <i>Drosophila</i> hepatocyte-like cells induces cardiac dysfunction through the pro-inflammatory cytokine Upd3 Open
Age is a major risk factor for cardiovascular diseases. Currently, the non-autonomous regulation of age-related cardiac dysfunction is poorly understood. In the present study, we discover that age-dependent induction of cytokine unpaired 3…
View article: Drosophila mRNA Localization During Later Development: Past, Present, and Future
Drosophila mRNA Localization During Later Development: Past, Present, and Future Open
Multiple mechanisms tightly regulate mRNAs during their transcription, translation, and degradation. Of these, the physical localization of mRNAs to specific cytoplasmic regions is relatively easy to detect; however, linking localization t…
View article: Distinct Roles for Peroxisomal Targeting Signal Receptors Pex5 and Pex7 in <i>Drosophila</i>
Distinct Roles for Peroxisomal Targeting Signal Receptors Pex5 and Pex7 in <i>Drosophila</i> Open
Peroxisomes are ubiquitous membrane-enclosed organelles involved in lipid processing and reactive oxygen detoxification. Mutations in human peroxisome biogenesis genes (Peroxin, PEX, or Pex) cause developmental disabilities and often early…
View article: Dysfunctional peroxisomes compromise gut structure and host defense by increased cell death and Tor-dependent autophagy
Dysfunctional peroxisomes compromise gut structure and host defense by increased cell death and Tor-dependent autophagy Open
The gut has a central role in digestion and nutrient absorption, but it also serves in defending against pathogens, engages in mutually beneficial interactions with commensals, and is a major source of endocrine signals. Gut homeostasis is…
View article: Functional characterization of peroxisome biogenic proteins Pex5 and Pex7 of <i>Drosophila</i>
Functional characterization of peroxisome biogenic proteins Pex5 and Pex7 of <i>Drosophila</i> Open
Peroxisomes are ubiquitous membrane-enclosed organelles involved in lipid processing and reactive oxygen detoxification. Mutations in human peroxisome biogenesis genes ( Peroxin , PEX ) cause progressive developmental disabilities and, in …
View article: Moesin is involved in polarity maintenance and cortical remodeling during asymmetric cell division
Moesin is involved in polarity maintenance and cortical remodeling during asymmetric cell division Open
An intact actomyosin network is essential for anchoring polarity proteins to the cell cortex and maintaining cell size asymmetry during asymmetric cell division of Drosophila neuroblasts (NBs). However, the mechanisms that control changes …
View article: A Systematic Cell‐Based Analysis of Localization of Predicted <i>Drosophila</i> Peroxisomal Proteins
A Systematic Cell‐Based Analysis of Localization of Predicted <i>Drosophila</i> Peroxisomal Proteins Open
Peroxisomes are membrane‐bound organelles found in almost all eukaryotic cells. They perform specialized biochemical functions that vary with organism, tissue or cell type. Mutations in human genes required for the assembly of peroxisomes …