Explanipedia

Dynamics of Preparatory Apneas and Their Influence on Maximal Dry Static Apnea in Breath-Hold Divers Open

Andrew T. Lovering, Joseph W. Duke · 2025

Background: Physiological and psychological factors are important for determining static breath-hold duration. Preconditioning, such as preparatory apneas at functional residual capacity, is a potentially valuable method for prolonging bre…

When sex is not the reason for your breathlessness: clinical insights into exertional dyspnoea from dead space loading during exercise Open

Andrew T. Lovering · 2025

Reduction in respiratory muscle strength following a series of preparatory and maximal static, dry breath-holds Open

Colin D. Hubbard, Dario Vrdoljak, Geoff B. Coombs, Troy J. Cross, Bryan J. Taylor , et al. · 2025

Respiratory muscle fatigue could occur following involuntary breathing movements during maximal breath-holds. We measured respiratory muscle strength pre and post three preparatory and maximal breath-holds. We found significant reductions …

Maintenance of core temperature in SCUBA divers in cold water: contributions of anthropometrics, suit type, and sex Open

Tucker Orman, Karleigh E. Bradbury, Tim Grosshennig, Margarita Pérez, Fabian Möller , et al. · 2025

Maintenance of core temperature (Tc) is vital for health and physiological function while SCUBA diving in cold water, but there is little research investigating the influence of anthropometrics, suit type, and sex on the rate of change in …

Respiratory muscle strength pre- and post-maximal apneas in a world champion breath-hold diver Open

Joseph W. Duke, Colin D. Hubbard, Dario Vrdoljak, Geoff B. Coombs, Andrew T. Lovering , et al. · 2024

Previous work has suggested that respiratory muscle fatigue may result from maximal breath-holds but this has not been measured. We measured respiratory muscle strength pre- and post-maximal apneas in a world champion breath-hold diver. We…

Acute exposure to carbon monoxide inhalation and/or hot water immersion transiently increases erythropoietin in females but not in males Open

Kaitlyn G. DiMarco, Christopher L. Chapman, Natasha E. Weiser, Emma R. Matsell, Kathryn M. Lucernoni , et al. · 2024

The use of acute carbon monoxide inhalation (COi) and hot water immersion (HWI) are of growing interest as interventions to stimulate erythropoietin (EPO) production. However, whether EPO production is further augmented when combining thes…

AltitudeOmics: effects of 16 days acclimatization to hypobaric hypoxia on muscle oxygen extraction during incremental exercise Open

Nicolas Bourdillon, Andrew W. Subudhi, Jui‐Lin Fan, Oghenero Evero, Jonathan E. Elliott , et al. · 2023

During incremental exercise muscle deoxyhemoglobin (HHb) and oxygen consumption (V̇o 2 ) both increase linearly, and the slope of their relationship is an indirect index of local muscle O 2 extraction. The latter was assessed at sea level, …

Right Ventricular Response to Acute Hypoxia among Healthy Humans Open

Lindsay M. Forbes, Todd Bull, Tim Lahm, Justin S. Lawley, Kendall S. Hunter , et al. · 2023

indicating that subphenotype assignment also has strong prognostic relevance in children with ARF but not PARDS.Recent investigations in adults with ARF without ARDS also support the existence of two subphenotypes with characteristics simi…

Consequences of Preterm Birth: Knowns, Unknowns, and Barriers to Advancing Cardiopulmonary Health Open

Colin D. Hubbard, Melissa L. Bates, Andrew T. Lovering, Joseph W. Duke · 2023

Synopsis Preterm birth occurs in 10% of all live births and creates challenges to neonatal life, which persist into adulthood. Significant previous work has been undertaken to characterize and understand the respiratory and cardiovascular …

Hyperoxia-induced stepwise reduction in blood flow through intrapulmonary, but not intracardiac, shunt during exercise Open

James Davis, Jonathan E. Elliott, Joseph W. Duke, Alberto Cristobal, Andrew T. Lovering · 2023

Blood flow through intrapulmonary arteriovenous anastomoses (IPAVA) ( Q IPAVA ) increases during exercise breathing air, but it has been proposed that Q IPAVA is reduced during exercise while breathing a fraction of inspired oxygen ([Formu…

Exercise Training Improves Exercise Capacity in Preterm-Born Adults: Lessons for Clinical Trials? Open

Kara N. Goss, Andrew T. Lovering · 2023

"Exercise Training Improves Exercise Capacity in Preterm-Born Adults: Lessons for Clinical Trials?." American Journal of Respiratory and Critical Care Medicine, 0(ja), pp. –

Sex Differences in VO2max and the Impact on Endurance-Exercise Performance Open

Kelsey J. Santisteban, Andrew T. Lovering, John R. Halliwill, Christopher T. Minson · 2022

It was not until 1984 that women were permitted to compete in the Olympic marathon. Today, more women than men participate in road racing in all distances except the marathon where participation is near equal. From the period of 1985 to 20…

Regulation of Hypoxic Pulmonary Vasoconstriction in Lowlanders and Healthy Andean Highlanders Open

Joseph W. Duke, Andrew T. Lovering · 2022

Quantification of Shunt Fraction Using Contrast Ultrasound and Indicator Dilution in an in Vitro Model Open

Lindsey M. Boulet, Paul D. Cotton, Frank A. Petrassi, Andrew T. Lovering, Glen E. Foster · 2022

Physiological aspects of cardiopulmonary dysanapsis on exercise in adults born preterm Open

Joseph W. Duke, Adam J. Lewandowski, Steven H. Abman, Andrew T. Lovering · 2021

Progressive improvements in perinatal care and respiratory management of preterm infants have resulted in increased survival of newborns of extremely low gestational age over the past few decades. However, the incidence of bronchopulmonary…

Differential Brain and Muscle Tissue Oxygenation Responses to Exercise in Tibetans Compared to Han Chinese Open

Jui‐Lin Fan, Tian Wu, Andrew T. Lovering, Liya Nan, Wang Bang , et al. · 2021

The Tibetans’ better aerobic exercise capacity at altitude remains ill-understood. We tested the hypothesis that Tibetans display better muscle and brain tissue oxygenation during exercise in hypoxia. Using near-infrared spectrometry (NIRS…

Respiratory and cardiopulmonary limitations to aerobic exercise capacity in adults born preterm Open

Joseph W. Duke, Andrew T. Lovering · 2020

Adults born preterm, regardless of whether they develop bronchopulmonary dysplasia, have underdeveloped respiratory and cardiopulmonary systems. The resulting impaired respiratory and cardiopulmonary systems are inadequate for the challeng…

Premature Aging and Increased Risk of Adult Cardiorespiratory Disease after Extreme Preterm Birth. Getting to the Heart (and Lungs) of the Matter Open

Joseph W. Duke, Andrew T. Lovering, Kara N. Goss · 2020

Unchanged cerebrovascular CO<sub>2</sub> reactivity and hypercapnic ventilatory response during strict head‐down tilt bed rest in a mild hypercapnic environment Open

Steven S. Laurie, Kate H. Christian, Jacob E. Kysar, Stuart M. C. Lee, Andrew T. Lovering , et al. · 2020

Key points Carbon dioxide levels are mildly elevated on the International Space Station and it is unknown whether this chronic exposure causes physiological changes to astronauts. We combined ∼4 mmHg ambient with the strict head‐down tilt …

Impact of Altitude on Cardiopulmonary and Right Ventricular Hemodynamics During Exercise Open

William K. Cornwell, Andrew T. Lovering · 2020

Conveniences of modern travel allow for an increasing number of people to sojourn to mountainous, high-altitude locations for work and/or pleasure. Travel to these types of locations places unique stressors on the human body and, more spec…

AltitudeOmics: Spontaneous Baroreflex Sensitivity During Acclimatization to 5,260 m: A Comparison of Methods Open

Nicolas Bourdillon, Sasan Yazdani, Jean-Marc Vésin, Andrew W. Subudhi, Andrew T. Lovering , et al. · 2019

Supplementary material corresponding to submitted work in the Journal of Applied Physiology

Analysis of maximal expiratory flow-volume curves in adult survivors of preterm birth Open

Yannick Molgat‐Seon, Paolo B. Dominelli, Carli M. Peters, Jordan A. Guenette, A. William Sheel , et al. · 2019

Adult survivors of very preterm (≤32 wk gestational age) birth without (PRE) and with bronchopulmonary dysplasia (BPD) have variable degrees of airflow obstruction at rest. Assessment of the shape of the maximal expiratory flow-volume (MEF…

Ventilatory responses to acute hypoxia and hypercapnia in humans with a patent foramen ovale Open

James Davis, Lindsey M. Boulet, Alyssa M. Hardin, Alex J. Chang, Andrew T. Lovering , et al. · 2018

Subjects with a patent foramen ovale (PFO) have blunted ventilatory acclimatization to high altitude compared with subjects without PFO. The blunted response observed could be because of differences in central and/or peripheral respiratory…

Alleviating mechanical constraints to ventilation with heliox improves exercise endurance in adult survivors of very preterm birth Open

Joseph W. Duke, Amy Zidron, Igor M. Gladstone, Andrew T. Lovering · 2018

Adult survivors of very preterm birth (PRET) have significantly lower aerobic exercise capacities than their counterparts born at term (CONT), but the underlying cause is unknown. To test whether expiratory flow limitation (EFL) during exe…

AltitudeOmics: Baroreflex Sensitivity During Acclimatization to 5,260 m Open

Nicolas Bourdillon, Sasan Yazdani, Andrew W. Subudhi, Andrew T. Lovering, Robert C. Roach , et al. · 2018

Introduction: Baroreflex sensitivity (BRS) is essential to ensure rapid adjustment to variations in blood pressure (BP). Little is known concerning the adaptive responses of BRS during acclimatization to high altitude at rest and du…

CORRIGENDUM Open

Frank A. Petrassi, James Davis, Kara M. Beasley, Oghenero Evero, Jonathan E. Elliott , et al. · 2018

Adaptive remodeling of skeletal muscle energy metabolism in high-altitude hypoxia: Lessons from AltitudeOmics Open

Adam J. Chicco, Catherine Le, Erich Gnaiger, Hans C. Dreyer, Jonathan B. Muyskens , et al. · 2018

Metabolic responses to hypoxia play important roles in cell survival strategies and disease pathogenesis in humans. However, the homeostatic adjustments that balance changes in energy supply and demand to maintain organismal function under…

AltitudeOmics: effect of reduced barometric pressure on detection of intrapulmonary shunt, pulmonary gas exchange efficiency, and total pulmonary resistance Open

Frank A. Petrassi, James Davis, Kara M. Beasley, Oghenero Evero, Jonathan E. Elliott , et al. · 2018

Blood flow through intrapulmonary arteriovenous anastomoses (Q IPAVA ) occurs in healthy humans at rest and during exercise when breathing hypoxic gas mixtures at sea level and may be a source of right-to-left shunt. However, at high altit…

Premature birth affects the degree of airway dysanapsis and mechanical ventilatory constraints Open

Joseph W. Duke, Igor M. Gladstone, A. William Sheel, Andrew T. Lovering · 2017

New Findings What is the central question of this study? Adult survivors of preterm birth without (PRE) and with bronchopulmonary dysplasia (BPD) have airflow obstruction at rest and significant mechanical ventilatory constraints during ex…

Bubble and macroaggregate methods differ in detection of blood flow through intrapulmonary arteriovenous anastomoses in upright and supine hypoxia in humans Open

Joseph W. Duke, Jonathan E. Elliott, Steven S. Laurie, Thomas Voelkel, Igor M. Gladstone , et al. · 2017

Blood flow through intrapulmonary arteriovenous anastomoses (Q̇ IPAVA ) increases in healthy humans breathing hypoxic gas and is potentially dependent on body position. Previous work in subjects breathing room air has shown an effect of bod…

Andrew T. Lovering YOU? Author Swipe