Andrew W. Tai
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View article: SARS-CoV-2 remodels the Golgi apparatus to facilitate viral assembly and secretion
SARS-CoV-2 remodels the Golgi apparatus to facilitate viral assembly and secretion Open
The COVID-19 pandemic is caused by the enveloped virus SARS-CoV-2. Despite extensive investigation, the molecular mechanisms for its assembly and secretion remain largely elusive. Here, we show that SARS-CoV-2 infection induces global alte…
View article: Dengue and Zika virus NS4B proteins differ in topology and in determinants of ER membrane protein complex dependency
Dengue and Zika virus NS4B proteins differ in topology and in determinants of ER membrane protein complex dependency Open
Flaviviruses utilize the cellular endoplasmic reticulum (ER) for all aspects of their lifecycle. Genome replication and other viral activities take place in structures called replication organelles (ROs), which are invaginations induced in…
View article: SLC4A11 mediates ammonia import and promotes cancer stemness in hepatocellular carcinoma
SLC4A11 mediates ammonia import and promotes cancer stemness in hepatocellular carcinoma Open
End-stage liver disease is marked by portal hypertension, systemic elevations in ammonia, and development of hepatocellular carcinoma (HCC). While these clinical consequences of cirrhosis are well described, it remains poorly understood wh…
View article: SLC4A11 mediates ammonia import and promotes cancer stemness in hepatocellular carcinoma
SLC4A11 mediates ammonia import and promotes cancer stemness in hepatocellular carcinoma Open
End stage liver disease is marked by portal hypertension, systemic elevations in ammonia, and development of hepatocellular carcinoma (HCC). While these clinical consequences of cirrhosis are well described, it remains poorly understood wh…
View article: Self-Assembled STING-Activating Coordination Nanoparticles for Cancer Immunotherapy and Vaccine Applications
Self-Assembled STING-Activating Coordination Nanoparticles for Cancer Immunotherapy and Vaccine Applications Open
The cGAS-STING pathway plays a crucial role in innate immune activation against cancer and infections, and STING agonists based on cyclic dinucleotides (CDN) have garnered attention for their potential use in cancer immunotherapy and vacci…
View article: Group Incentive Compatibility in a Market with Indivisible Goods: A Comment
Group Incentive Compatibility in a Market with Indivisible Goods: A Comment Open
View article: Type I interferon signaling induces a delayed antiproliferative response in respiratory epithelial cells during SARS-CoV-2 infection
Type I interferon signaling induces a delayed antiproliferative response in respiratory epithelial cells during SARS-CoV-2 infection Open
Disease progression during SARS-CoV-2 infection is tightly linked to the fate of lung epithelial cells, with severe cases of COVID-19 characterized by direct injury of the alveolar epithelium and an impairment in its regeneration from prog…
View article: House-Swapping with Objective Indifferences
House-Swapping with Objective Indifferences Open
We study the classic house-swapping problem of Shapley and Scarf (1974) in a setting where agents may have "objective" indifferences, i.e., indifferences that are shared by all agents. In other words, if any one agent is indifferent betwee…
View article: How to Effectively Engage With Preclinical Medical Learners
How to Effectively Engage With Preclinical Medical Learners Open
Medical education, and in particular preclinical medical education, has undergone significant changes over the past 10–15 years. Changes have been driven at multiple levels, including initiatives by individual medical schools, large-scale …
View article: Reticulons promote formation of ER-derived double-membrane vesicles that facilitate SARS-CoV-2 replication
Reticulons promote formation of ER-derived double-membrane vesicles that facilitate SARS-CoV-2 replication Open
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the etiologic agent for the global COVID-19 pandemic, triggers the formation of endoplasmic reticulum (ER)-derived replication organelles, including double-membrane vesicles (DM…
View article: STING agonist-loaded mesoporous manganese-silica nanoparticles for vaccine applications
STING agonist-loaded mesoporous manganese-silica nanoparticles for vaccine applications Open
View article: High-Content Screening to Identify Inhibitors of Dengue Virus Replication
High-Content Screening to Identify Inhibitors of Dengue Virus Replication Open
Dengue Virus (DENV) causes dengue fever, a pandemic-potential disease with currently no FDA-approved antivirals. Additionally, the available vaccine for DENV can increase the risk of severe dengue fever for those who have never had a DENV …
View article: Type I interferon signaling induces a delayed antiproliferative response in Calu-3 cells during SARS-CoV-2 infection
Type I interferon signaling induces a delayed antiproliferative response in Calu-3 cells during SARS-CoV-2 infection Open
Disease progression during SARS-CoV-2 infection is tightly linked to the fate of lung epithelial cells, with severe cases of COVID-19 characterized by direct injury of the alveolar epithelium and an impairment in its regeneration from prog…
View article: Is there a multinational consensus of tobramycin prescribing and monitoring for cystic fibrosis? Survey of current therapeutic drug monitoring practices in USA/Canada, UK/Ireland, and Australia/New Zealand
Is there a multinational consensus of tobramycin prescribing and monitoring for cystic fibrosis? Survey of current therapeutic drug monitoring practices in USA/Canada, UK/Ireland, and Australia/New Zealand Open
There remains substantial heterogeneity in tobramycin management worldwide. Despite two decades of research into TDM of tobramycin, there has been a slow uptake of new technologies and evolution of practice. An improved understanding of TD…
View article: Revealed Preferences of One-Sided Matching
Revealed Preferences of One-Sided Matching Open
Consider the object allocation (one-sided matching) model of Shapley and Scarf (1974). When final allocations are observed but agents' preferences are unknown, when might the allocation be in the core? This is a one-sided analogue of the m…
View article: A specific EMC subunit supports Dengue virus infection by promoting virus membrane fusion essential for cytosolic genome delivery
A specific EMC subunit supports Dengue virus infection by promoting virus membrane fusion essential for cytosolic genome delivery Open
Dengue virus (DENV) represents the most common human arboviral infection, yet its cellular entry mechanism remains unclear. The multi-subunit endoplasmic reticulum membrane complex (EMC) supports DENV infection, in part, by assisting the b…
View article: SARS-CoV-2 remodels the Golgi apparatus to facilitate viral assembly and secretion
SARS-CoV-2 remodels the Golgi apparatus to facilitate viral assembly and secretion Open
The COVID-19 pandemic is caused by SARS-CoV-2, an enveloped RNA virus. Despite extensive investigation, the molecular mechanisms for its assembly and secretion remain largely elusive. Here, we show that SARS-CoV-2 infection induces global …
View article: Identification of cell type specific ACE2 modifiers by CRISPR screening
Identification of cell type specific ACE2 modifiers by CRISPR screening Open
SARS-CoV-2 infection is initiated by binding of the viral spike protein to its receptor, ACE2, on the surface of host cells. ACE2 expression is heterogeneous both in vivo and in immortalized cell lines, but the molecular pathways that gove…
View article: Spike Antibody Assays Can Screen For Viral Neutralizing Activity Toward SARS-CoV-2
Spike Antibody Assays Can Screen For Viral Neutralizing Activity Toward SARS-CoV-2 Open
View article: Vaccination against COVID-19 Leads to Enhanced Immunity Despite Infection History
Vaccination against COVID-19 Leads to Enhanced Immunity Despite Infection History Open
View article: Amilorides inhibit SARS-CoV-2 replication in vitro by targeting RNA structures
Amilorides inhibit SARS-CoV-2 replication in vitro by targeting RNA structures Open
Small-molecule targeting of RNA stem loops in 5′-end of SARS-CoV-2 reveals novel RNA targets for viral inhibition.
View article: A Combination Adjuvant for the Induction of Potent Antiviral Immune Responses for a Recombinant SARS-CoV-2 Protein Vaccine
A Combination Adjuvant for the Induction of Potent Antiviral Immune Responses for a Recombinant SARS-CoV-2 Protein Vaccine Open
Several SARS-CoV-2 vaccines have received EUAs, but many issues remain unresolved, including duration of conferred immunity and breadth of cross-protection. Adjuvants that enhance and shape adaptive immune responses that confer broad prote…
View article: Mild SARS-CoV-2 Illness Is Not Associated with Reinfections and Provides Persistent Spike, Nucleocapsid, and Virus-Neutralizing Antibodies
Mild SARS-CoV-2 Illness Is Not Associated with Reinfections and Provides Persistent Spike, Nucleocapsid, and Virus-Neutralizing Antibodies Open
This article demonstrates that people who have mild COVID-19 illnesses and produce antibodies are protected from reinfection for up to 6 months afterward. The antibodies that people produce in this situation are stable for up to 6 months a…
View article: Directed evolution of potent neutralizing nanobodies against SARS-CoV-2 using CDR-swapping mutagenesis
Directed evolution of potent neutralizing nanobodies against SARS-CoV-2 using CDR-swapping mutagenesis Open
View article: Oral simethicone tablets with PEG‐ELS split‐prep reduces frequency of inadequate bowel cleansing and decreases bubbles
Oral simethicone tablets with PEG‐ELS split‐prep reduces frequency of inadequate bowel cleansing and decreases bubbles Open
Background: Intraluminal bubbles may prevent the visualisation of mucosa during a colonoscopy. Simethicone minimises bubbles, but its impact on incomplete bowel preparation and optimal protocols for use are unclear. Aim: To assess the impa…
View article: Identification of ACE2 modifiers by CRISPR screening
Identification of ACE2 modifiers by CRISPR screening Open
SARS-CoV-2 infection is initiated by binding of the viral spike protein to its receptor, ACE2, on the surface of host cells. ACE2 expression is heterogeneous both in vivo and in immortalized cell lines, but the molecular pathways that gove…
View article: Author response for "Oral Simethicone Tablets with PEG‐ELS Split‐Prep Reduces Frequency of Inadequate Bowel Cleansing and Decreases Bubbles"
Author response for "Oral Simethicone Tablets with PEG‐ELS Split‐Prep Reduces Frequency of Inadequate Bowel Cleansing and Decreases Bubbles" Open
View article: IgV somatic mutation of human anti–SARS-CoV-2 monoclonal antibodies governs neutralization and breadth of reactivity
IgV somatic mutation of human anti–SARS-CoV-2 monoclonal antibodies governs neutralization and breadth of reactivity Open
Abs that neutralize SARS-CoV-2 are thought to provide the most immediate and effective treatment for those severely afflicted by this virus. Because coronavirus potentially diversifies by mutation, broadly neutralizing Abs are especially s…
View article: A Combination Adjuvant for the Induction of Potent Antiviral Immune Responses for a Recombinant SARS-CoV-2 Protein Vaccine
A Combination Adjuvant for the Induction of Potent Antiviral Immune Responses for a Recombinant SARS-CoV-2 Protein Vaccine Open
Several SARS-CoV-2 vaccines have received EUAs, but many issues remain unresolved, including duration of conferred immunity and breadth of cross-protection. Adjuvants that enhance and shape adaptive immune responses that confer broad prote…
View article: Amilorides inhibit SARS-CoV-2 replication in vitro by targeting RNA structures
Amilorides inhibit SARS-CoV-2 replication in vitro by targeting RNA structures Open
The SARS-CoV-2 pandemic, and the likelihood of future coronavirus pandemics, has rendered our understanding of coronavirus biology more essential than ever. Small molecule chemical probes offer to both reveal novel aspects of virus replica…