Andrew W. Patterson
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View article: Discovery of Ligands for TRIM58, a Novel Tissue-Selective E3 Ligase
Discovery of Ligands for TRIM58, a Novel Tissue-Selective E3 Ligase Open
Redirecting E3 ligases to neo-substrates, leading to their proteasomal disassembly, known as targeted protein degradation (TPD), has emerged as a promising alternative to traditional, occupancy-driven pharmacology. Although the field has e…
View article: Discovery of a Novel, Highly Potent and Orally Bioavailable Pyrrolidinone Indole Series of Irreversible Myeloperoxidase (MPO) Inhibitors
Discovery of a Novel, Highly Potent and Orally Bioavailable Pyrrolidinone Indole Series of Irreversible Myeloperoxidase (MPO) Inhibitors Open
View article: Discovery of a novel indole pharmacophore for the irreversible inhibition of myeloperoxidase (MPO)
Discovery of a novel indole pharmacophore for the irreversible inhibition of myeloperoxidase (MPO) Open
View article: Discovery of 1-((6-Aminopyridin-3-yl)Methyl)-3-(4-Bromophenyl)Urea as a Potent, Irreversible Myeloperoxidase Inhibitor
Discovery of 1-((6-Aminopyridin-3-yl)Methyl)-3-(4-Bromophenyl)Urea as a Potent, Irreversible Myeloperoxidase Inhibitor Open