Andrew Conway Morris
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View article: Impact of statins on short and long term mortality in severe community acquired pneumonia in the intensive care unit
Impact of statins on short and long term mortality in severe community acquired pneumonia in the intensive care unit Open
Severe community-acquired pneumonia (sCAP) carries high mortality. While co-adjuvant therapies remain limited, statins have shown potential benefits. This study simulated a randomised controlled trial (RCT) using real-world data to evaluat…
View article: Cortisol-resistant Chimeric Antigen Receptor (CAR)-NK cells overcome steroid-induced immunosuppression in lung cancer 9085
Cortisol-resistant Chimeric Antigen Receptor (CAR)-NK cells overcome steroid-induced immunosuppression in lung cancer 9085 Open
Description Tumour microenvironments (TME) accumulate immunosuppressive steroids, impairing NK cell anti-tumour immunity. We found glucocorticoid cortisol signalling enrichment in lung TME exacerbates hypoxic stress and impairs NK cell fun…
View article: The role of corticosteroids in the management of non-COVID-19 severe community-acquired pneumonia in the intensive care unit: A narrative review
The role of corticosteroids in the management of non-COVID-19 severe community-acquired pneumonia in the intensive care unit: A narrative review Open
Severe community-acquired pneumonia (sCAP) is associated with a significant health burden, both in the UK and globally, with intensive care support needed for many patients. The high morbidity and mortality associated with sCAP has led to …
View article: Severe viral infections requiring intensive care unit admissions- aetiology, co-infections, respiratory interventions and outcomes
Severe viral infections requiring intensive care unit admissions- aetiology, co-infections, respiratory interventions and outcomes Open
Introduction Severe viral infections are common in patients requiring admission to intensive care units (ICU). Furthermore, these patients often have additional secondary or co-infections. Despite their prevalence, it remains uncertain to …
View article: The impact of intensive care strain on patients’ outcomes—a multinational observational cohort (UNITE-COVID) study
The impact of intensive care strain on patients’ outcomes—a multinational observational cohort (UNITE-COVID) study Open
Purpose Intensive care unit (ICU) strain is associated with increased mortality. Most strain metrics focus on ‘simple’ measures such as bed occupancy or admission rates. There is limited data on mitigation strategies, such as procedure tea…
View article: Top 10 research priorities for sepsis research determined by patients, carers and clinicians
Top 10 research priorities for sepsis research determined by patients, carers and clinicians Open
Summary Introduction Sepsis is a high burden syndrome associated with increased morbidity and mortality in both the acute and longer‐term phases of illness. Multiple treatment uncertainties remain that require resolution through high‐quali…
View article: Perturbing local steroidogenesis to improve breast cancer immunity
Perturbing local steroidogenesis to improve breast cancer immunity Open
Breast cancer, particularly triple-negative breast cancer (TNBC), evades the body’s immune defences, in part by cultivating an immunosuppressive tumour microenvironment. Here, we show that suppressing local steroidogenesis can augment anti…
View article: Corticosteroids for the management of severe community-acquired pneumonia: A UK-wide survey
Corticosteroids for the management of severe community-acquired pneumonia: A UK-wide survey Open
The use of corticosteroids in severe community-acquired pneumonia (sCAP) management is a contentious issue with current practices of United Kingdom (UK) intensivists largely unknown. To investigate this, we surveyed UK intensive care clini…
View article: The impact of Intensive Care Strain on Patients’ Outcomes during COVID-19 - a UNITE COVID study
The impact of Intensive Care Strain on Patients’ Outcomes during COVID-19 - a UNITE COVID study Open
Purpose Intensive care unit (ICU) strain is associated with increased mortality. Most strain metrics focus on ‘simple’ measures such as bed occupancy or admission rates. There is limited data on mitigation strategies, such as procedure tea…
View article: A Delphi Process to Determine the Bellwether Procedures for Trauma Systems Globally: A Study Protocol
A Delphi Process to Determine the Bellwether Procedures for Trauma Systems Globally: A Study Protocol Open
Introduction Traumatic injuries are responsible for a huge amount of mortality, morbidity, and disability globally. Within global surgery, Bellwether procedures have previously been identified to measure the surgical proficiency of a hospi…
View article: Retrospective service evaluation of clinical pharmacist involvement in a critical care COVID-19 rehabilitation clinic
Retrospective service evaluation of clinical pharmacist involvement in a critical care COVID-19 rehabilitation clinic Open
Medication reconciliation ensures healthcare providers prioritise safe and optimal use of medicines. It should occur at each transition in care setting. On admission to critical care, clinical focus changes from effective management of chr…
View article: Prone positioning is associated with increased insulin requirements in mechanically ventilated patients with COVID-19
Prone positioning is associated with increased insulin requirements in mechanically ventilated patients with COVID-19 Open
Stress hyperglycaemia is common in critical illness. We have previously observed that increasing severity of respiratory failure in patients with severe COVID-19 is associated with increased insulin demand. Given previously reported direct…
View article: Bronchoscopic Diagnosis of Severe Respiratory Infections
Bronchoscopic Diagnosis of Severe Respiratory Infections Open
The diagnosis of severe respiratory infections in intensive care remains an area of uncertainty and involves a complex balancing of risks and benefits. Due to the frequent colonisation of the lower respiratory tract in mechanically ventila…
View article: Efficacy of air cleaning units for preventing SARS-CoV-2 and other hospital-acquired infections on medicine for older people wards: a quasi-experimental controlled before-and-after study
Efficacy of air cleaning units for preventing SARS-CoV-2 and other hospital-acquired infections on medicine for older people wards: a quasi-experimental controlled before-and-after study Open
ACUs may reduce SARS-CoV-2 infection to a clinically meaningfully degree. Larger studies could reduce uncertainty, perhaps using a crossover design, and factors influencing acceptability to staff and patients should be explored further.
View article: The unique metabolic and lipid profiles of patients with severe COVID-19 compared to severe community-acquired pneumonia: a potential prognostic and therapeutic target
The unique metabolic and lipid profiles of patients with severe COVID-19 compared to severe community-acquired pneumonia: a potential prognostic and therapeutic target Open
Not applicable.
View article: Pulmonary inflammation in severe pneumonia is characterised by compartmentalised and mechanistically distinct sub-phenotypes
Pulmonary inflammation in severe pneumonia is characterised by compartmentalised and mechanistically distinct sub-phenotypes Open
Pneumonia is the leading infectious disease killer worldwide and commonly requires admission to critical care. Despite its prevalence, the underpinning biology of severe pneumonia remains incompletely understood. We performed multifaceted …
View article: Changes in the Firmicutes to Bacteriodetes ratio in the gut microbiome in individuals with anorexia nervosa following inpatient treatment: A systematic review and a case series
Changes in the Firmicutes to Bacteriodetes ratio in the gut microbiome in individuals with anorexia nervosa following inpatient treatment: A systematic review and a case series Open
Objective Anorexia nervosa has the highest mortality rate among psychiatric illnesses. Current treatments remain ineffective for a large fraction of patients. This may be due to unclear mechanisms behind its development and maintenance. St…
View article: D-PRISM, a global study of diagnostic approaches in severe pneumonia.
D-PRISM, a global study of diagnostic approaches in severe pneumonia. Open
Purpose Pneumonia remains a significant global health concern, particularly among those requiring admission to the intensive care unit (ICU). Despite the availability of international guidelines there remains heterogeneity in clinical mana…
View article: Evaluating patient factors, operative management and postoperative outcomes in trauma laparotomy patients worldwide: a protocol for a global observational multicentre trauma study
Evaluating patient factors, operative management and postoperative outcomes in trauma laparotomy patients worldwide: a protocol for a global observational multicentre trauma study Open
Introduction Trauma contributes to the greatest loss of disability-adjusted life-years for adolescents and young adults worldwide. In the context of global abdominal trauma, the trauma laparotomy is the most commonly performed operation. V…
View article: Enhanced diagnosis of severe bacterial and fungal respiratory infection in children using a rapid syndromic array—case report
Enhanced diagnosis of severe bacterial and fungal respiratory infection in children using a rapid syndromic array—case report Open
The pathogens included on molecular arrays and interpretation by a multidisciplinary team are crucial in providing value to PICU diagnostic services. Molecular arrays have the potential to enhance early pathogen-specific diagnosis of LRTI …