Andrey А. Mikhaylov
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View article: Bathochromic Shift via C=O to C=S Substitution: A Far-Red Fluorogen for Multiplexed FLIM with FAST Fluorogen-Activating Protein
Bathochromic Shift via C=O to C=S Substitution: A Far-Red Fluorogen for Multiplexed FLIM with FAST Fluorogen-Activating Protein Open
The palette of the fluorogen-activating protein FAST expanded into the far-red region by the development of a novel fluorogen, HBTR-3,5-DOM. This was achieved through a C=O to C=S substitution in the classic hydroxybenzylidene-rhodanine co…
View article: [3 + 2] Cycloaddition of thioformylium methylide with various arylidene-azolones in the synthesis of 7-thia-3-azaspiro[4.4]nonan-4-ones
[3 + 2] Cycloaddition of thioformylium methylide with various arylidene-azolones in the synthesis of 7-thia-3-azaspiro[4.4]nonan-4-ones Open
Thioformylium methylide, which is readily generated from chloromethyl(trimethylsilyl)methyl sulfide by the action of fluoride, is used for the synthesis of spirocyclic derivatives from arylidene-azolones. Four types of the corresponding he…
View article: Photochemically-Enabled Umpolung Conversion of 2-Acyloxybenzaldehydes into 2-Hydroxybenzofuranones
Photochemically-Enabled Umpolung Conversion of 2-Acyloxybenzaldehydes into 2-Hydroxybenzofuranones Open
2-Acyloxybenzaldehydes are converted into 2-hydroxybenzofuranones in good to excellent yields (60–99%). The reaction proceeds at room temperature in DMSO upon 365 nm LED irradiation under photocatalyst-free conditions. The present atom-eco…
View article: Synthesis of Chroman Derivatives by Group Transposition and Atom Swap of 1-Tetralones. Single Atom Editing Enabled by Contractive Oxidation of Benzoxepine Silyl Ketene Acetals
Synthesis of Chroman Derivatives by Group Transposition and Atom Swap of 1-Tetralones. Single Atom Editing Enabled by Contractive Oxidation of Benzoxepine Silyl Ketene Acetals Open
Single-atom editing of complex molecules is steadily filling the chemical toolbox with site-selective modification reactions. Herein, a stepwise scheme for carbon-to-oxygen swap in tetralins leading to privileged chroman scaffolds is prese…
View article: Study on 1,4-hydride shift triggered spirocyclization of arylidene imidazolones: substituent control on formation of indane or tetrahydrobenzazepine systems
Study on 1,4-hydride shift triggered spirocyclization of arylidene imidazolones: substituent control on formation of indane or tetrahydrobenzazepine systems Open
A rare process of 1,4-hydride or formal 1,6-hydride shift occurs in the (o-dialkylaminomethyl)arylidene imidazolones under the action of aluminum chloride. Only sterically hindered amino derivatives are able to enter the spirocyclization r…
View article: Molecular Decoration and Unconventional Double Bond Migration in Irumamycin Biosynthesis
Molecular Decoration and Unconventional Double Bond Migration in Irumamycin Biosynthesis Open
Irumamycin (Iru) is a complex polyketide with pronounced antifungal activity produced by a type I polyketide (PKS) synthase. Iru features a unique hemiketal ring and an epoxide group, making its biosynthesis and the structural diversity of…
View article: Arylidene-imidazolones and their acyclic analogue as fluorescent sensors of metal ions
Arylidene-imidazolones and their acyclic analogue as fluorescent sensors of metal ions Open
We report about a series of methylene-imidazolones with complexing groups. The fluorescent properties of these compounds were studied in various solvents as well as in the presence of different salts. We discovered that two of the synthesi…
View article: Synthesis of ortho-carboxamidostilbene analogues and their antidiabetic activity through in vitro and in silico approaches
Synthesis of ortho-carboxamidostilbene analogues and their antidiabetic activity through in vitro and in silico approaches Open
Due to the recent emergence of drug-resistance of antidiabetic drugs and the increase in the number of diabetes cases around the world, the search for and discovery of more effective α-amylase inhibitors is of great interest.In the present…
View article: CCDC 2096253: Experimental Crystal Structure Determination
CCDC 2096253: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2096254: Experimental Crystal Structure Determination
CCDC 2096254: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Synthesis and biological activity of imidazole phenazine derivatives as potential inhibitors for NS2B-NS3 dengue protease
Synthesis and biological activity of imidazole phenazine derivatives as potential inhibitors for NS2B-NS3 dengue protease Open
A series of new imidazole-phenazine derivatives were synthesized via a two-step process. The condensation of 2,3-diaminophenazine and benzaldehyde derivatives proceeds with intermediate formation of an aniline Schiff base, which undergoes …
View article: KuINins as a New Class of HIV-1 Inhibitors That Block Post-Integration DNA Repair
KuINins as a New Class of HIV-1 Inhibitors That Block Post-Integration DNA Repair Open
Integration of HIV-1 genomic cDNA results in the formation of single-strand breaks in cellular DNA, which must be repaired for efficient viral replication. Post-integration DNA repair mainly depends on the formation of the HIV-1 integrase …
View article: Results of research work Russian society of oncomammologists “The use of artificial intelligence for early detection of breast cancer”
Results of research work Russian society of oncomammologists “The use of artificial intelligence for early detection of breast cancer” Open
Breast cancer is the most common cancer in women and one of the leading causes of death from cancer in Russia and most countries of the world. In countries with mammographic screening, there is a decrease in mortality from breast cancer. I…
View article: CCDC 2193771: Experimental Crystal Structure Determination
CCDC 2193771: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2193768: Experimental Crystal Structure Determination
CCDC 2193768: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2193767: Experimental Crystal Structure Determination
CCDC 2193767: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2193765: Experimental Crystal Structure Determination
CCDC 2193765: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2193766: Experimental Crystal Structure Determination
CCDC 2193766: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2193770: Experimental Crystal Structure Determination
CCDC 2193770: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2193769: Experimental Crystal Structure Determination
CCDC 2193769: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2202410: Experimental Crystal Structure Determination
CCDC 2202410: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2193637: Experimental Crystal Structure Determination
CCDC 2193637: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: [1,5]-Hydride Shift Triggered N-Dealkylative Cyclization into 2-Oxo-1,2,3,4-tetrahydroquinoline-3-carboxylates via Boronate Complexes
[1,5]-Hydride Shift Triggered N-Dealkylative Cyclization into 2-Oxo-1,2,3,4-tetrahydroquinoline-3-carboxylates via Boronate Complexes Open
A new simple one-pot two-step protocol for the synthesis of 2-oxo-1,2,3,4-tetrahydroquinoline-3-carboxylate from 2-(2-(benzylamino)benzylidene)malonate under the action of BF3·Et2O was developed. It was shown that the reaction proceeds thr…
View article: CCDC 2123315: Experimental Crystal Structure Determination
CCDC 2123315: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2123316: Experimental Crystal Structure Determination
CCDC 2123316: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2012447: Experimental Crystal Structure Determination
CCDC 2012447: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1960553: Experimental Crystal Structure Determination
CCDC 1960553: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …