Andrey P. Anokhin
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View article: The Relationship between Alcohol Use Disorder, Measures of Cognitive Decline, and Alzheimer Disease Biomarkers in Older Adults
The Relationship between Alcohol Use Disorder, Measures of Cognitive Decline, and Alzheimer Disease Biomarkers in Older Adults Open
Background Alcohol use disorder (AUD) is associated with increased risks of neuropsychiatric conditions and dementia. However, the association between Alzheimer disease (AD) and AUD is poorly characterized. To address this, we studied asso…
View article: Author Correction: Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction
Author Correction: Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction Open
View article: Hippocampal volumes in UK Biobank are associated with <i>APOE</i> only in older adults
Hippocampal volumes in UK Biobank are associated with <i>APOE</i> only in older adults Open
INTRODUCTION The hippocampus atrophies with age and is implicated in neurodegenerative disorders including Alzheimer's disease (AD). We examined the interplay between age and apolipoprotein E ( APOE ) genotype on total hippocampal volume. …
View article: Alcohol, smoking, and brain structure: common or substance specific associations
Alcohol, smoking, and brain structure: common or substance specific associations Open
Alcohol use and smoking are common substance-use behaviors with well-established negative health effects, including decreased brain health. We examined whether alcohol use and smoking were associated with the same neuroimaging-derived brai…
View article: Hippocampal volumes in UK Biobank are associated with APOE only in older adults
Hippocampal volumes in UK Biobank are associated with APOE only in older adults Open
INTRODUCTION The hippocampus atrophies with age and is implicated in neurodegenerative disorders including Alzheimer’s disease (AD). We examined the interplay between age and APOE genotype on total hippocampal volume. METHODS Utilizing neu…
View article: Alcohol milestones and internalizing, externalizing, and executive function: longitudinal and polygenic score associations
Alcohol milestones and internalizing, externalizing, and executive function: longitudinal and polygenic score associations Open
Background Although the link between alcohol involvement and behavioral phenotypes (e.g. impulsivity, negative affect, executive function [EF]) is well-established, the directionality of these associations, specificity to stages of alcohol…
View article: Kenya Psychosis-Risk Outcomes Study (KePROS): Development of an Accelerated Medicine Partnership Schizophrenia-Aligned Project in Africa
Kenya Psychosis-Risk Outcomes Study (KePROS): Development of an Accelerated Medicine Partnership Schizophrenia-Aligned Project in Africa Open
Background and Hypothesis The Accelerating Medicines Partnership Schizophrenia (AMP SCZ) funds a longitudinal study of 43 research sites across 5 continents to develop tools to stratify developmental trajectories of youth at clinical high …
View article: Diagnostic Criteria for Identifying Individuals at High Risk of Progression From Mild or Moderate to Severe Alcohol Use Disorder
Diagnostic Criteria for Identifying Individuals at High Risk of Progression From Mild or Moderate to Severe Alcohol Use Disorder Open
Importance Current Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition) ( DSM-5 ) diagnoses of substance use disorders rely on criterion count–based approaches, disregarding severity grading indexed by individual criteria.…
View article: Investigating the Relationship Between Smoking Behavior and Global Brain Volume
Investigating the Relationship Between Smoking Behavior and Global Brain Volume Open
View article: Examining associations between genetic and neural risk for externalizing behaviors in adolescence and early adulthood
Examining associations between genetic and neural risk for externalizing behaviors in adolescence and early adulthood Open
Background Researchers have identified genetic and neural risk factors for externalizing behaviors. However, it has not yet been determined if genetic liability is conferred in part through associations with more proximal neurophysiologica…
View article: Predicting Alcohol-Related Memory Problems in Older Adults: A Machine Learning Study with Multi-Domain Features
Predicting Alcohol-Related Memory Problems in Older Adults: A Machine Learning Study with Multi-Domain Features Open
Memory problems are common among older adults with a history of alcohol use disorder (AUD). Employing a machine learning framework, the current study investigates the use of multi-domain features to classify individuals with and without al…
View article: Investigating causal relationship between smoking behavior and global brain volume
Investigating causal relationship between smoking behavior and global brain volume Open
Background Previous studies have shown that brain volume is negatively associated with cigarette smoking, but there is an ongoing debate whether smoking causes lowered brain volume or a lower brain volume is a risk factor for smoking. We a…
View article: Predicting alcohol-related memory problems in older adults: A machine learning study with multi-domain features
Predicting alcohol-related memory problems in older adults: A machine learning study with multi-domain features Open
Memory problems are common among older adults with a history of alcohol use disorder (AUD). Employing a machine learning framework, the current study investigates the use of multi-domain features to classify individuals with and without al…
View article: Predicting Alcohol-Related Memory Problems in Older Adults: A Machine Learning Study with Multi-Domain Features
Predicting Alcohol-Related Memory Problems in Older Adults: A Machine Learning Study with Multi-Domain Features Open
View article: Associations of parent–adolescent closeness with <scp>P3</scp> amplitude, frontal theta, and binge drinking among offspring with high risk for alcohol use disorder
Associations of parent–adolescent closeness with <span>P3</span> amplitude, frontal theta, and binge drinking among offspring with high risk for alcohol use disorder Open
Background Parents impact their offspring's brain development, neurocognitive function, risk, and resilience for alcohol use disorder (AUD) via both genetic and socio‐environmental factors. Individuals with AUD and their unaffected childre…
View article: Polygenic Contributions to Suicidal Thoughts and Behaviors in a Sample Ascertained for Alcohol Use Disorders
Polygenic Contributions to Suicidal Thoughts and Behaviors in a Sample Ascertained for Alcohol Use Disorders Open
Introduction: Suicidal thoughts and behaviors have partially distinct genetic etiologies. Methods: We used PRS-CS to create polygenic risk scores (PRSs) from GWAS of non-suicidal self-injury, broad-sense self-ha…
View article: Clinical, environmental, and genetic risk factors for substance use disorders: characterizing combined effects across multiple cohorts
Clinical, environmental, and genetic risk factors for substance use disorders: characterizing combined effects across multiple cohorts Open
View article: Parsing genetically influenced risk pathways: genetic loci impact problematic alcohol use via externalizing and specific risk
Parsing genetically influenced risk pathways: genetic loci impact problematic alcohol use via externalizing and specific risk Open
View article: Polygenic contributions to suicidal thoughts and behaviors in a sample ascertained for alcohol use disorders
Polygenic contributions to suicidal thoughts and behaviors in a sample ascertained for alcohol use disorders Open
Suicidal thoughts and behaviors have partially distinct genetic etiologies. We used PRS-CS to create polygenic risk scores (PRS) from GWAS of non-suicidal self-injury, broad sense self-harm ideation, non-fatal suicide attempt, death by sui…
View article: Reliability and stability challenges in ABCD task fMRI data
Reliability and stability challenges in ABCD task fMRI data Open
Trait stability of measures is an essential requirement for individual differences research. Functional MRI has been increasingly used in studies that rely on the assumption of trait stability, such as attempts to relate task related brain…
View article: Measuring retention within the adolescent brain cognitive development (ABCD)SM study
Measuring retention within the adolescent brain cognitive development (ABCD)SM study Open
View article: Age-related changes and longitudinal stability of individual differences in ABCD Neurocognition measures
Age-related changes and longitudinal stability of individual differences in ABCD Neurocognition measures Open
View article: Clinical, Environmental, and Genetic Risk Factors for Substance Use Disorders: Characterizing Combined Effects across Multiple Cohorts
Clinical, Environmental, and Genetic Risk Factors for Substance Use Disorders: Characterizing Combined Effects across Multiple Cohorts Open
Substance use disorders (SUDs) incur serious social and personal costs. Risk for SUDs is complex, ranging from social conditions to individual genetic variation. We examined whether models that include a clinical/environmental risk index (…
View article: High Polygenic Risk Scores Are Associated With Early Age of Onset of Alcohol Use Disorder in Adolescents and Young Adults at Risk
High Polygenic Risk Scores Are Associated With Early Age of Onset of Alcohol Use Disorder in Adolescents and Young Adults at Risk Open
View article: Reliability and Stability Challenges in ABCD Task fMRI Data
Reliability and Stability Challenges in ABCD Task fMRI Data Open
Trait stability of measures is an essential requirement for individual differences research. Functional MRI has been increasingly used in studies that rely on the assumption of trait stability, such as attempts to relate task related brain…
View article: Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction
Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction Open
View article: Substance use patterns in 9-10 year olds: Baseline findings from the adolescent brain cognitive development (ABCD) study
Substance use patterns in 9-10 year olds: Baseline findings from the adolescent brain cognitive development (ABCD) study Open
View article: Mapping Pathways by Which Genetic Risk Influences Adolescent Externalizing Behavior: The Interplay Between Externalizing Polygenic Risk Scores, Parental Knowledge, and Peer Substance Use
Mapping Pathways by Which Genetic Risk Influences Adolescent Externalizing Behavior: The Interplay Between Externalizing Polygenic Risk Scores, Parental Knowledge, and Peer Substance Use Open
View article: Baseline brain function in the preadolescents of the ABCD Study
Baseline brain function in the preadolescents of the ABCD Study Open
View article: Item-Level Genome-Wide Association Study of the Alcohol Use Disorders Identification Test in Three Population-Based Cohorts
Item-Level Genome-Wide Association Study of the Alcohol Use Disorders Identification Test in Three Population-Based Cohorts Open
This work further emphasizes the value of AUDIT for both clinical and genetic studies of AUD and the importance of using multivariate methods to study genetic associations that are more closely related to AUD.