Andrey Panchenko
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View article: Analysis of Spontaneous Behavior Patterns of Male Rhesus Macaques Exposed to Voluntary Ethanol Consumption Over Two-Year Period
Analysis of Spontaneous Behavior Patterns of Male Rhesus Macaques Exposed to Voluntary Ethanol Consumption Over Two-Year Period Open
BACKGROUND: The onset of mental disorders associated with chronic ethanol use without dependence and safe threshold for alcohol consumption remain unclear. AIM: To describe changes in the spontaneous behavior patterns of rhesus macaques in…
View article: Effect of BP-C2 Polyphenolic Composition in Irradiated Danio rerio Fish on Induced Liver Carcinogenesis in Second Generation Offspring
Effect of BP-C2 Polyphenolic Composition in Irradiated Danio rerio Fish on Induced Liver Carcinogenesis in Second Generation Offspring Open
Введение. Экспериментальные исследования на млекопитающих указывают на возможный риск сохранения нарушений, вызванных облучением родителей, у потомков не только первого, но и второго поколения. В связи с этим важной задачей является поиск …
View article: Carcinogenic Risk in the Offspring of Preconceptionally Irradiated Mammals: A Systematic Review
Carcinogenic Risk in the Offspring of Preconceptionally Irradiated Mammals: A Systematic Review Open
Введение. Изучение феномена трансгенерационных эффектов ионизирующего излучения насчитывает не один десяток лет. Одним из возможных последствий облучения родителей может быть изменение частоты и спектра развития злокачественных новообразов…
View article: Evaluation of the Potential of Hybrid Tri-Component Nanosystems Based on Selenium Nanoparticles, Graft Copolymers and Radachlorin for Targeted Tumor Delivery
Evaluation of the Potential of Hybrid Tri-Component Nanosystems Based on Selenium Nanoparticles, Graft Copolymers and Radachlorin for Targeted Tumor Delivery Open
Введение. В качестве перспективных наноструктурированных материалов для адресной доставки лекарственных веществ рассматриваются сополимеры с полиимидной или целлюлозной основной цепью и боковыми цепями полиметакриловой кислоты. В работе пр…
View article: Monkeys as a model object for studying degenerativedystrophic alteration in the human spine
Monkeys as a model object for studying degenerativedystrophic alteration in the human spine Open
Degenerative-dystrophic alteration in the spine (DDAS) is a chronic progressive pathology characterized by changes in the intervertebral discs, joints, ligaments, and bone tissue of the vertebrae; manifested by severe orthopedic, neurologi…
View article: A complicated form of spontaneous aortic atherosclerosis in an African green monkeys (Chlorocebus aethiops sabaeus) male. Clinical case
A complicated form of spontaneous aortic atherosclerosis in an African green monkeys (Chlorocebus aethiops sabaeus) male. Clinical case Open
Atherosclerosis is the mechanistic basis of cardiovascular disorders manifested by damage to the walls of the aorta, coronary, cerebral and peripheral arteries, leading to the development of acute or chronic ischemia of internal organs and…
View article: Monkeys excluding apes as a model for studies on metabolic syndrome
Monkeys excluding apes as a model for studies on metabolic syndrome Open
Aim . To summarize the results of research on metabolic syndrome in monkeys excluding apes and to conduct a comparison with humans.A search for full-text publications in PubMed and Scopus databases was carried out using the following keywo…
View article: Effect of Polyphenol Composition BP-C2 on the Rate of Liver Tumor Reversion of Transgenic Progeny of Irradiated Fish Danio Rerio
Effect of Polyphenol Composition BP-C2 on the Rate of Liver Tumor Reversion of Transgenic Progeny of Irradiated Fish Danio Rerio Open
Введение. Отдаленными последствиями использования радиотерапии или химиотерапии у онкологических пациентов могут быть вторые первичные опухоли, нарушения фертильности, а также негативное влияние на здоровье потомства. Поэтому поиск средств…
View article: THE ROLE OF piRNAs IN ONCOGENESIS: A REVIEW OF ASSOCIATIONS
THE ROLE OF piRNAs IN ONCOGENESIS: A REVIEW OF ASSOCIATIONS Open
Background. The cumulation of data on molecular genetic events associated with oncogenesis resulted into transformation of the understanding of the role of small non-coding RNAs in the process. The largest class of these molecules is repre…
View article: Crude oil sorbent based on cellulose nanofibrils-methacrylate grafted copolymers
Crude oil sorbent based on cellulose nanofibrils-methacrylate grafted copolymers Open
Hydrophobic composites of cellulose nanofibrils (CNF) with acrylic polymers are obtained by methyl methacrylate (MMA) and butyl methacrylate (BMA) polymerization in Pickering emulsion, stabilized with cellulose nanofibrils. Successful modi…
View article: Efficiency of the Combined Photodynamic Therapy with Cisplatin in the Treatment of B16 Melanoma in C57BL/6 Mice
Efficiency of the Combined Photodynamic Therapy with Cisplatin in the Treatment of B16 Melanoma in C57BL/6 Mice Open
Введение. Фотодинамическая терапия — один из современных методов лечения опухолевых и предопухолевых заболеваний. Данный метод имеет ряд ограничений, одним из направлений преодоления которых может быть его комбинирование с химиотерапевтиче…
View article: Toward the Anniversary of the First National Experimental Oncology Laboratory
Toward the Anniversary of the First National Experimental Oncology Laboratory Open
В статье изложены основные этапы развития и направления научных исследований старейшей отечественной экспериментально-онкологической лаборатории, созданной по инициативе Н.Н. Петрова в 1926 г. Рассмотрены важнейшие результаты, полученные с…
View article: Composite Bone Cements with Enhanced Drug Elution
Composite Bone Cements with Enhanced Drug Elution Open
Antibiotic-loaded bone cement (ALBC) has become an indispensable material in orthopedic surgery in recent decades, owing to the possibility of drugs delivery to the surgical site. It is applied for both infection prophylaxis (e.g., in prim…
View article: Urethane-induced transgenerational carcinogenesis in the offsprings of BALB/c male mice exposed to total body gamma irradiation
Urethane-induced transgenerational carcinogenesis in the offsprings of BALB/c male mice exposed to total body gamma irradiation Open
Введение. Геномная нестабильность, возникшая под влиянием ионизирующей радиации или химических канцерогенов противоопухолевой терапии представляет потенциальную угрозу не только для самих пациентов, но возможно и для их потомства. Цель исс…
View article: Effects of Isoflavone-Rich NADES Extract of Pueraria lobata Roots and Astaxanthin-Rich Phaffia rhodozyma Extract on Prostate Carcinogenesis in Rats
Effects of Isoflavone-Rich NADES Extract of Pueraria lobata Roots and Astaxanthin-Rich Phaffia rhodozyma Extract on Prostate Carcinogenesis in Rats Open
Prostate cancer (PCa) is one of the most common male malignancies worldwide. In the current study, we evaluated the effects of a natural deep eutectic solvent (NADES) extract of Pueraria lobata roots rich in isoflavones (ISF) and Phaffia r…
View article: Association of alcohol consumption with telomere length in humans: a systematic review
Association of alcohol consumption with telomere length in humans: a systematic review Open
Telomeres are complex nucleoprotein structures with specific proteins of noncoding terminal regions of linear chromosomes of eukaryotic cells. Telomere DNA consists of a large number of short sequence repeats (TTAGGG in vertebrates). Telom…
View article: Analysis of In Vivo Radachlorin Accumulation through FLIM-Assisted Examination of Ex Vivo Histological Samples
Analysis of In Vivo Radachlorin Accumulation through FLIM-Assisted Examination of Ex Vivo Histological Samples Open
We report an investigation of the in vivo accumulation of Radachlorin photosensitizer in a murine model in several types of normal and tumor tissues based on an FLIM-assisted analysis of fluorescence intensity images, time-resolved fluores…
View article: Assessment of antitumor activity of BP-C1, a platinum-based anticancer agent with a lignin-derived polymeric ligand, in autochthonous induced and spontaneous carcinogenesis rodent models
Assessment of antitumor activity of BP-C1, a platinum-based anticancer agent with a lignin-derived polymeric ligand, in autochthonous induced and spontaneous carcinogenesis rodent models Open
The results acquired indicated a wide spectrum of antitumor activity of BP-C1.
View article: Antigenotoxic and antimutagenic effects of lignin derivative BP-C2 against dioxidine and cyclophosphamide in vivo in murine cells
Antigenotoxic and antimutagenic effects of lignin derivative BP-C2 against dioxidine and cyclophosphamide in vivo in murine cells Open
View article: Astaxantin and Isoflavones Inhibit Benign Prostatic Hyperplasia in Rats by Reducing Oxidative Stress and Normalizing Ca/Mg Balance
Astaxantin and Isoflavones Inhibit Benign Prostatic Hyperplasia in Rats by Reducing Oxidative Stress and Normalizing Ca/Mg Balance Open
Benign prostatic hyperplasia (BPH) is a common pathology among aging men. Despite the broad pharmacological interventions, the available remedies to treat BPH are yet not devoid of side effects. Herbal compounds are suggested to be an alte…
View article: The effect of constant light and melatonin on urethane-induced lung carcinogenesis in mice and expression of clock genes and proteins
The effect of constant light and melatonin on urethane-induced lung carcinogenesis in mice and expression of clock genes and proteins Open
Introduction. Circadian rhythms are an adaptational mechanism to day-night cycle. At the cellular level rhythms are supported by oscillations of transcription of Bmal1, 2, Clock and Npas2, Per1-3, Cry1, 2 clock genes; in the organism rhyth…
View article: Efficacy and Safety of Systemic and Locoregional Cisplatin Chronotherapy in Rats with Ovarian Carcinoma
Efficacy and Safety of Systemic and Locoregional Cisplatin Chronotherapy in Rats with Ovarian Carcinoma Open
In a rat model, ovarian tumor growth disrupted daily variations in intestinal epithelium proliferation and caused genotoxic stress in tumor-free tissues. HIPEC with cisplatin at ZT0 had a better efficacy/toxicity profile than HIPEC with ci…
View article: A titanium implant for Chiari malformation Type 1 surgery
A titanium implant for Chiari malformation Type 1 surgery Open
Background: Concepts of Chiari malformation Type 1 (CM1) surgery in the present time significantly different. The most common complications are pseudomeningocele (12%) and postoperative CSF leak (5%). The development of pseudomeningocele m…
View article: METHODOLOGICAL ASPECTS OF PHOTODYNAMIC THERAPY OF EHRLICH SOLID CARCINOMA IN BALB/C MOUSE STRAIN WITH VARIOUS TUMOR LOCALIZATION
METHODOLOGICAL ASPECTS OF PHOTODYNAMIC THERAPY OF EHRLICH SOLID CARCINOMA IN BALB/C MOUSE STRAIN WITH VARIOUS TUMOR LOCALIZATION Open
Background . Photodynamic Therapy is one of the treatment methods used in modern oncology. Evaluation of the efficacy in vivo of photosensitizers on tumor models is generally accepted, but the photodynamic therapy technique in mice is not …
View article: DISRUPTED DAILY OSCILLATIONS OF CLOCK GENES EXPRESSION AND CLOCK PROTEINS CONTENT IN TUMORS AND DISTANT TISSUES IN HER2/NEU TRANSGENIC MICE
DISRUPTED DAILY OSCILLATIONS OF CLOCK GENES EXPRESSION AND CLOCK PROTEINS CONTENT IN TUMORS AND DISTANT TISSUES IN HER2/NEU TRANSGENIC MICE Open
The connection between circadian rhythms and cancer is bilateral at the body and cellular level. Negative impact of tumor development on circadian rhythms represents one of its aspects. Materials and methods. 16 FVB/N and 16 FVB/N transgen…
View article: Ballistic opportunities' evaluation of artillery projectile with a rocket ramjet
Ballistic opportunities' evaluation of artillery projectile with a rocket ramjet Open
Based on the analysis of existing technical solutions, promising structural designs of ammunition with rocket ramjet of 130, 152, and 203 mm caliber have been developed.Mathematical models of the ballistic functioning of artillery projecti…
View article: Assessment of pharmacokinetics and biological effects of lignin-derived polyphenolic compositions BP-C3 and BP-C2 in in vivo models
Assessment of pharmacokinetics and biological effects of lignin-derived polyphenolic compositions BP-C3 and BP-C2 in in vivo models Open
View article: BP-C2 (complexes of molybdenum with polymer of benzene polycarboxylic acids derived from lignin): Evaluation of antigenotoxic potential in COMET assay
BP-C2 (complexes of molybdenum with polymer of benzene polycarboxylic acids derived from lignin): Evaluation of antigenotoxic potential in COMET assay Open
View article: Novel polyphenolic ligand of BP-Cx family drugs: cell distribution and mechanism of action
Novel polyphenolic ligand of BP-Cx family drugs: cell distribution and mechanism of action Open
View article: Enchancement of Toremifene Anti-Tumor Action by Metformin and Unusual Side Effect of Toremifene in Male Transgenic Mice with HER2-Positive Breast Tumor
Enchancement of Toremifene Anti-Tumor Action by Metformin and Unusual Side Effect of Toremifene in Male Transgenic Mice with HER2-Positive Breast Tumor Open
HER2-positive breast tumors are found in 25–30% of patients with breast cancer and are characterized by aggressive course and reduced sensitivity to both chemotherapy and hormone therapy. The aim of the work was to study the possibilities …