Andrey Shatskiy
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View article: Visible light-mediated dearomative spirocyclization/imination of nonactivated arenes through energy transfer catalysis
Visible light-mediated dearomative spirocyclization/imination of nonactivated arenes through energy transfer catalysis Open
Aromatic compounds serve as key feedstocks in the chemical industry, typically undergoing functionalization or full reduction. However, partial reduction via dearomative sequences remains underexplored despite its potential to rapidly gene…
View article: Site‐Selective C─H Bond Functionalization of Sugars
Site‐Selective C─H Bond Functionalization of Sugars Open
Non‐typical C‐functionalized sugars represent a prominent yet hardly accessible class of biologically‐active compounds. The available synthetic methodologies toward such sugar derivatives suffer either from an extensive use of protecting g…
View article: Site‐Selective C─H Bond Functionalization of Sugars
Site‐Selective C─H Bond Functionalization of Sugars Open
Non‐typical C‐functionalized sugars represent a prominent yet hardly accessible class of biologically‐active compounds. The available synthetic methodologies toward such sugar derivatives suffer either from an extensive use of protecting g…
View article: Access to Carbonyl Azides via Iodine(III)-Mediated Cross-Coupling
Access to Carbonyl Azides via Iodine(III)-Mediated Cross-Coupling Open
Herein, we present a prominent metal-free C-N cross-coupling platform that enables access to carbamoyl- and ketoazides from isocyanides or silyl enol ethers and trimethylsilyl azide (TMSN3) with an aid of iodine(III) promoter. This offers …
View article: Site-Selective C–H Bond Functionalization of Native Sugars
Site-Selective C–H Bond Functionalization of Native Sugars Open
Non-typical C-functionalized sugars represent a prominent yet hardly accessible class of biologically-active compounds. The available synthetic methodologies towards such sugar derivatives suffer either from an extensive use of protecting …
View article: Safe-and-Sustainable-by-Design Approach to Non-Toxic Bisphenol Polymers
Safe-and-Sustainable-by-Design Approach to Non-Toxic Bisphenol Polymers Open
The majority of contemporary chemical processes rely on non-renewable resources and reagents associated with negative impact on environment and human health. For this reason, the Safe-and-Sustainable-by-Design (SSbD) framework was launched…
View article: General Approach to Amides through Decarboxylative Radical Cross-Coupling of Carboxylic Acids and Isocyanides
General Approach to Amides through Decarboxylative Radical Cross-Coupling of Carboxylic Acids and Isocyanides Open
Herein, we report a silver-catalyzed protocol for decarboxylative cross-coupling between carboxylic acids and isocyanides, leading to linear amide products through a free-radical mechanism. The disclosed approach provides a general entry t…
View article: Visible Light-Mediated Dearomative Spirocyclization/Imination of Nonactivated Arenes through Energy Transfer Catalysis
Visible Light-Mediated Dearomative Spirocyclization/Imination of Nonactivated Arenes through Energy Transfer Catalysis Open
Aromatic compounds are one of the most abundant feedstocks in chemical industry, which typically focuses on their functionalization or full reduction. Partial reduction through dearomative sequences has been considerably less explored but …
View article: Exploiting Photoredox Catalysis for Rapid Access to Unnatural α-Amino Acids through α-Amino C–H Bond Activation
Exploiting Photoredox Catalysis for Rapid Access to Unnatural α-Amino Acids through α-Amino C–H Bond Activation Open
Unnatural amino acids (UAAs) have shown great potential to enhance the pharmacological properties of peptides and represent a key motif in a wide range of biologically relevant natural products. Herein, we disclose a protocol that facilita…
View article: Asymmetric synthesis of unnatural α-amino acids through photoredox-mediated C–O bond activation of aliphatic alcohols
Asymmetric synthesis of unnatural α-amino acids through photoredox-mediated C–O bond activation of aliphatic alcohols Open
A practical protocol for the stereoselective synthesis of unnatural α-amino acids is disclosed, using ubiquitous aliphatic alcohols as radical precursors to form the α-amino acid backbone under redox-neutral photoredox-mediated conditions.
View article: CCDC 2210931: Experimental Crystal Structure Determination
CCDC 2210931: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2210960: Experimental Crystal Structure Determination
CCDC 2210960: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Construction of Phenanthridinone Skeletons through Palladium-Catalyzed Annulation
Construction of Phenanthridinone Skeletons through Palladium-Catalyzed Annulation Open
Herein, a straightforward synthetic approach for the construction of phenanthridin-6(5H)-one skeletons is disclosed. The developed protocol relies on palladium catalysis, providing controlled access to a range of functionalized phenanthrid…
View article: Asymmetric Synthesis of Unnatural α-Amino Acids through Photoredox-Mediated C–O Bond Activation of Aliphatic Alcohols
Asymmetric Synthesis of Unnatural α-Amino Acids through Photoredox-Mediated C–O Bond Activation of Aliphatic Alcohols Open
An efficient protocol for the asymmetric synthesis of unnatural amino acids is realized through photoredox-mediated C–O bond activation of oxalate esters derived from aliphatic alcohols as the radical precursors. The developed system uses …
View article: CCDC 2176172: Experimental Crystal Structure Determination
CCDC 2176172: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2195117: Experimental Crystal Structure Determination
CCDC 2195117: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Tandem Palladium/Copper-Catalyzed Decarboxylative Approach to Benzoimidazo- and Imidazophenanthridine Skeletons
Tandem Palladium/Copper-Catalyzed Decarboxylative Approach to Benzoimidazo- and Imidazophenanthridine Skeletons Open
A protocol for a tandem Pd/Cu-catalyzed intermolecular cross-coupling cascade between o-bromobenzoic acids and 2-(2-bromoaryl)-1H-benzo[d]imidazoles or the corresponding imidazoles is presented. The protocol provides conceptually novel and…
View article: Electrosynthetic C−O Bond Activation in Alcohols and Alcohol Derivatives
Electrosynthetic C−O Bond Activation in Alcohols and Alcohol Derivatives Open
Alcohols and their derivatives are ubiquitous and versatile motifs in organic synthesis. Deoxygenative transformations of these compounds are often challenging due to the thermodynamic penalty associated with the cleavage of the C−O bond. …
View article: Electrosynthetic C−O Bond Activation in Alcohols and Alcohol Derivatives
Electrosynthetic C−O Bond Activation in Alcohols and Alcohol Derivatives Open
Alcohols and their derivatives are ubiquitous and versatile motifs in organic synthesis. Deoxygenative transformations of these compounds are often challenging due to the thermodynamic penalty associated with the cleavage of the C−O bond. …
View article: Silver-Catalyzed Controlled Intermolecular Cross-Coupling of Silyl Enol Ethers: Scalable Access to 1,4-Diketones
Silver-Catalyzed Controlled Intermolecular Cross-Coupling of Silyl Enol Ethers: Scalable Access to 1,4-Diketones Open
A protocol for silver-catalyzed controlled intermolecular cross-coupling of silyl enolates is disclosed. The protocol displays good functional group tolerance and allows efficient preparation of a series of synthetically useful 1,4-diketon…
View article: Ruthenium containing molecular electrocatalyst on glassy carbon for electrochemical water splitting
Ruthenium containing molecular electrocatalyst on glassy carbon for electrochemical water splitting Open
Immobilizing ruthenium containing molecular electrocatalyst onto glassy carbon surface through bipyridine linkers and MWCNTs for efficient water oxidation.
View article: Copper-assisted Wittig-type olefination of aldehydes with <i>p</i>-toluenesulfonylmethyl isocyanide
Copper-assisted Wittig-type olefination of aldehydes with <i>p</i>-toluenesulfonylmethyl isocyanide Open
A copper-assisted Wittig-type olefination of aldehydes and p -toluenesulfonyl isocyanide (TosMIC) is disclosed, providing an operationally simple approach to ( E )-vinyl sulfone with various functional groups under mild reaction conditions.
View article: A ruthenium-based catalyst on carbon electrodes for electrochemical water splitting
A ruthenium-based catalyst on carbon electrodes for electrochemical water splitting Open
Electrochemical water splitting constitutes one of the most promising strategies for converting water into hydrogen-based fuels, and this technology is predicted to play a key role in our transition towards a carbon-neutral energy economy.…
View article: The Impact of Ligand Carboxylates on Electrocatalyzed Water Oxidation
The Impact of Ligand Carboxylates on Electrocatalyzed Water Oxidation Open
Fossil fuel shortage and severe climate changes due to global warming have prompted extensive research on carbon-neutral and renewable energy resources. Hydrogen gas (H2), a clean and high energy density fuel, has emerged as a potential so…
View article: Stereoselective synthesis of unnatural α-amino acid derivatives through photoredox catalysis
Stereoselective synthesis of unnatural α-amino acid derivatives through photoredox catalysis Open
A protocol for stereoselective C-radical addition to a chiral glyoxylate-derived N-sulfinyl imine was developed through visible light-promoted photoredox catalysis, providing a convenient method for the synthesis of unnatural α-amino acids.
View article: Silver‐Catalyzed [3+1+1] Annulation of Nitrones with Isocyanoacetates as an Approach to 1,4,5‐Trisubstituted Imidazoles
Silver‐Catalyzed [3+1+1] Annulation of Nitrones with Isocyanoacetates as an Approach to 1,4,5‐Trisubstituted Imidazoles Open
A silver‐catalyzed protocol for [3+1+1] annulation of nitrones and isocyanoacetates is reported. The reaction is proposed to proceed through sequential [3+2] cycloaddition, ring‐opening, cyclization‐oxidation, and dealkylation, allowing ac…