Andrie C. Westerkamp
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View article: High-Dose Methylphenidate and Carboxylesterase 1 Genetic Variability in Patients With Attention-Deficit/Hyperactivity Disorder
High-Dose Methylphenidate and Carboxylesterase 1 Genetic Variability in Patients With Attention-Deficit/Hyperactivity Disorder Open
Purpose/Background Methylphenidate (MPH) is widely used to reduce symptoms of attention-deficit/hyperactivity disorder. Methylphenidate is metabolized by the carboxylesterase 1 (CES1) enzyme. Some patients need a very high dose of MPH to r…
View article: Increasing metformin concentrations and its excretion in both rat and porcine ex vivo normothermic kidney perfusion model
Increasing metformin concentrations and its excretion in both rat and porcine ex vivo normothermic kidney perfusion model Open
Introduction Metformin can accumulate and cause lactic acidosis in patients with renal insufficiency. Metformin is known to inhibit mitochondria, while renal secretion of the drug by proximal tubules indirectly requires energy. We investig…
View article: Metformin Preconditioning and Postconditioning to Reduce Ischemia Reperfusion Injury in an Isolated <i>Ex Vivo</i> Rat and Porcine Kidney Normothermic Machine Perfusion Model
Metformin Preconditioning and Postconditioning to Reduce Ischemia Reperfusion Injury in an Isolated <i>Ex Vivo</i> Rat and Porcine Kidney Normothermic Machine Perfusion Model Open
Metformin may act renoprotective prior to kidney transplantation by reducing ischemia‐reperfusion injury (IRI). This study examined whether metformin preconditioning and postconditioning during ex vivo normothermic machine perfusion (NMP) …
View article: Metformin Preconditioning Improves Hepatobiliary Function and Reduces Injury in a Rat Model of Normothermic Machine Perfusion and Orthotopic Transplantation
Metformin Preconditioning Improves Hepatobiliary Function and Reduces Injury in a Rat Model of Normothermic Machine Perfusion and Orthotopic Transplantation Open
Background. Preconditioning of donor livers before organ retrieval may improve organ quality after transplantation. We investigated whether preconditioning with metformin reduces preservation injury and improves hepatobiliary function in r…
View article: Comparing peri-operative complications of paediatric and adult anaesthesia
Comparing peri-operative complications of paediatric and adult anaesthesia Open
Risk factors for all peri-operative complications were similar for paediatric and adult anaesthesia. However, the incidence of specific complications differed between both age categories.
View article: Normothermic machine perfusion of donor livers without the need for human blood products
Normothermic machine perfusion of donor livers without the need for human blood products Open
Normothermic machine perfusion (NMP) enables viability assessment of donor livers prior to transplantation. NMP is frequently performed by using human blood products including red blood cells (RBCs) and fresh frozen plasma (FFP). Our aim w…
View article: Dual hypothermic oxygenated machine perfusion in liver transplants donated after circulatory death
Dual hypothermic oxygenated machine perfusion in liver transplants donated after circulatory death Open
Background Experimental studies have suggested that end-ischaemic dual hypothermic oxygenated machine perfusion (DHOPE) may restore hepatocellular energy status and reduce reperfusion injury in donation after circulatory death (DCD) liver …
View article: Oxygenated hypothermic machine perfusion after static cold storage improves endothelial function of extended criteria donor livers
Oxygenated hypothermic machine perfusion after static cold storage improves endothelial function of extended criteria donor livers Open
View article: Strict Selection Alone of Patients Undergoing Liver Transplantation for Hilar Cholangiocarcinoma Is Associated with Improved Survival
Strict Selection Alone of Patients Undergoing Liver Transplantation for Hilar Cholangiocarcinoma Is Associated with Improved Survival Open
Liver transplantation for hilar cholangiocarcinoma (hCCA) has regained attention since the Mayo Clinic reported their favorable results with the use of a neo-adjuvant chemoradiation protocol. However, debate remains whether the success of …
View article: Intraoperative frozen section analysis of the proximal bile ducts in hilar cholangiocarcinoma is of limited value
Intraoperative frozen section analysis of the proximal bile ducts in hilar cholangiocarcinoma is of limited value Open
Frozen section analysis ( FS ) during cancer surgery is widely used to assess resection margins. However, in hilar cholangiocarcinoma ( HCCA ), FS may be less reliable because of the specific growth characteristics of the tumor. The aim of…
View article: Oxygenated hypothermic machine perfusion improves bile output and bile composition of extended criteria donor livers
Oxygenated hypothermic machine perfusion improves bile output and bile composition of extended criteria donor livers Open
View article: Oxygenated hypothermic machine perfusion after static cold storage improves endothelial function of extended criteria donor livers
Oxygenated hypothermic machine perfusion after static cold storage improves endothelial function of extended criteria donor livers Open
View article: Normothermic machine perfusion of donor livers using a novel hemoglobin based oxygen carrier solution, eliminating the need for human blood products
Normothermic machine perfusion of donor livers using a novel hemoglobin based oxygen carrier solution, eliminating the need for human blood products Open
View article: Pre- and postconditioning effects of metformin in rat donor livers
Pre- and postconditioning effects of metformin in rat donor livers Open
View article: Oxygenated hypothermic machine perfusion in liver transplantation with donation after circulatory death grafts: First clinical series
Oxygenated hypothermic machine perfusion in liver transplantation with donation after circulatory death grafts: First clinical series Open
View article: Normothermic machine perfusion reduces bile duct injury and improves biliary epithelial function in rat donor livers
Normothermic machine perfusion reduces bile duct injury and improves biliary epithelial function in rat donor livers Open
Bile duct injury may occur during liver procurement and transplantation, especially in livers from donation after circulatory death (DCD) donors. Normothermic machine perfusion (NMP) has been shown to reduce hepatic injury compared to stat…
View article: Strategies to Improve Outcome after Transplantation of Extended Criteria Donor Livers
Strategies to Improve Outcome after Transplantation of Extended Criteria Donor Livers Open
To reduce the current imbalance between available donor livers and patients waiting for a new liver graft, suboptimal donor livers are increasingly accepted for liver transplantation. Examples of suboptimal donor livers are livers derived …
View article: Diffuse reflectance spectroscopy accurately quantifies various degrees of liver steatosis in murine models of fatty liver disease
Diffuse reflectance spectroscopy accurately quantifies various degrees of liver steatosis in murine models of fatty liver disease Open
DRS can quantify steatosis with good agreement to histopathological analysis. DRS may be useful for real-time objective evaluation of liver steatosis during liver transplantation, especially to differentiate between mild and moderate/sever…
View article: <em>Ex Situ</em> Normothermic Machine Perfusion of Donor Livers
<em>Ex Situ</em> Normothermic Machine Perfusion of Donor Livers Open
In contrast to conventional static cold preservation (0-4 °C), ex situ machine perfusion may provide better preservation of donor livers. Continuous perfusion of organs provides the opportunity to improve organ quality and allows ex situ v…
View article: Elderly donor liver grafts are not associated with a higher incidence of biliary complications after liver transplantation: results of a national multicenter study
Elderly donor liver grafts are not associated with a higher incidence of biliary complications after liver transplantation: results of a national multicenter study Open
Background Liver transplantation with livers grafts from elderly donors has been associated with a higher risk of biliary complications. The aim of this study was to examine whether our national protocol could contribute to a lower inciden…