Andrijana Koceva
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View article: Switch from premixed insulin analogue to degludec-liraglutide combination: a CGM study
Switch from premixed insulin analogue to degludec-liraglutide combination: a CGM study Open
Introduction Basal insulin with glucagon-like peptide-1 receptor agonist could be preferred over premixed insulin for intensification in type 2 diabetes due to better glycemic control, lower hypoglycemia risk, and favorable effects on body…
View article: Switch from premixed insulin analogue to degludec-liraglutide combination: a CGM study
Switch from premixed insulin analogue to degludec-liraglutide combination: a CGM study Open
Introduction Basal insulin with glucagon-like peptide-1 receptor agonist could be preferred over premixed insulin for intensification in type 2 diabetes due to better glycemic control, lower hypoglycemia risk, and favorable effects on body…
View article: Impact of Incretin-Based Therapy on Skeletal Muscle Health
Impact of Incretin-Based Therapy on Skeletal Muscle Health Open
Skeletal muscle is the largest insulin-sensitive tissue in the human body, playing a crucial role in glucose homeostasis, body mobility and overall metabolic health. In obesity and type 2 diabetes (T2D), skeletal muscle undergoes structura…
View article: Preconception use of GLP-1 and GLP-1/GIP receptor agonists for obesity treatment
Preconception use of GLP-1 and GLP-1/GIP receptor agonists for obesity treatment Open
Obesity is rising among women of reproductive age and significantly contributes to subfertility. If conception occurs, maternal obesity is associated with increased risks for both maternal and neonatal complications, with potential long-te…
View article: Indolent Mastocytosis and Bone Health: Molecular Mechanisms and Emerging Treatment Options
Indolent Mastocytosis and Bone Health: Molecular Mechanisms and Emerging Treatment Options Open
Mastocytosis is a heterogeneous group of disorders, distinguished by the monoclonal proliferation of mast cells (MCs) in one or more organs. While cutaneous mastocytosis (CM) is restricted to the skin, systemic mastocytosis (SM) presents w…
View article: Oral semaglutide for the treatment of obesity: a retrospective real-world study
Oral semaglutide for the treatment of obesity: a retrospective real-world study Open
Background Clinical obesity is a prevalent chronic disease, significantly increasing morbidity and mortality while impairing quality of life. As diet and physical activity interventions often prove ineffective in the long term, with increa…
View article: Amylin: From Mode of Action to Future Clinical Potential in Diabetes and Obesity
Amylin: From Mode of Action to Future Clinical Potential in Diabetes and Obesity Open
Precision diabetology is increasingly becoming diabetes phenotype-driven, whereby the specific hormonal imbalances involved are taken into consideration. Concomitantly, body weight-favorable therapeutic approaches are being dictated by the…
View article: The Impact of Hydration on Metabolic Outcomes: From Arginine-Vasopressin Signaling to Clinical Implications
The Impact of Hydration on Metabolic Outcomes: From Arginine-Vasopressin Signaling to Clinical Implications Open
Arginine-vasopressin peptide (AVP) plays a critical role in water balance and osmoregulation. However, emerging evidence suggests that AVP’s actions may expand beyond its traditional role, significantly influencing metabolic regulation, in…
View article: Case report: Long-term efficacy and safety of semaglutide in the treatment of syndromic obesity in Prader Willi syndrome - case series and literature review
Case report: Long-term efficacy and safety of semaglutide in the treatment of syndromic obesity in Prader Willi syndrome - case series and literature review Open
Introduction Prader-Willi syndrome (PWS) is the most prevalent cause of syndromic obesity. Obesity development in PWS is driven by dysfunction in neural pathways involved in satiety and reward, dysregulation in hormones regulating satiety …
View article: Insulinoma Unmasked: A Continuous Glucose Monitoring-Fueled Journey
Insulinoma Unmasked: A Continuous Glucose Monitoring-Fueled Journey Open
Insulinomas are rare functional neuroendocrine tumors that are usually indolent and small. Due to their rarity, there is often a delay in disease recognition and diagnosis, and small tumor size makes their localization challenging. Glucose…
View article: Sex- and Gender-Related Differences in Obesity: From Pathophysiological Mechanisms to Clinical Implications
Sex- and Gender-Related Differences in Obesity: From Pathophysiological Mechanisms to Clinical Implications Open
Obesity, primarily characterized by excessive fat accumulation, is a multifactorial chronic disease with an increasing global prevalence. Despite the well-documented epidemiology and significant advances in understanding its pathophysiolog…
View article: From Sweet to Sour: SGLT-2-Inhibitor-Induced Euglycemic Diabetic Ketoacidosis
From Sweet to Sour: SGLT-2-Inhibitor-Induced Euglycemic Diabetic Ketoacidosis Open
Sodium–glucose cotransporter 2 (SGLT-2) inhibitors are highly selective, effective, and generally well-tolerated antihyperglycemic agents targeting the SGLT-2 transmembrane protein. Despite being primarily registered for diabetes treatment…