Andrzej Bąk
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View article: Gemcitabine and Flurbiprofen Enhance Cytotoxic Effects on Cancer Cell Lines Mediated by Mesenchymal Stem Cells
Gemcitabine and Flurbiprofen Enhance Cytotoxic Effects on Cancer Cell Lines Mediated by Mesenchymal Stem Cells Open
Mesenchymal stem cells (MSCs) have recently shown great promise as potential anticancer drug delivery carriers. MSCs exhibit tropism to inflammatory sites, such as tumor beds, and resistance to chemotherapeutics. The aim of this study was …
View article: Spectroscopic and Chromatographic Characterization of Two Isomeric Cathinone Derivatives: N-Butyl-Norbutylone and N-Ethylhexylone
Spectroscopic and Chromatographic Characterization of Two Isomeric Cathinone Derivatives: N-Butyl-Norbutylone and N-Ethylhexylone Open
In this study, two isomeric cathinone derivatives, N-butyl-norbutylone and N-ethylhexylone, seized on the illicit drug market in Poland, were described and characterized by various instrumental analytical methods. The compounds were charac…
View article: Preparing a Liposome-Aided Drug Delivery System: The Entrapment and Release Profiles of Doxorubicin and 9-(N-Piperazinyl)-5-methyl-12(H)-quino [3,4-b][1,4]benzothiazinium Chloride with Human Serum Albumin
Preparing a Liposome-Aided Drug Delivery System: The Entrapment and Release Profiles of Doxorubicin and 9-(N-Piperazinyl)-5-methyl-12(H)-quino [3,4-b][1,4]benzothiazinium Chloride with Human Serum Albumin Open
Background/Objectives: The principal aim of this work was to prepare a liposomal drug delivery system based on the commercial drug doxorubicin (DOX) and a budding agent with promising anticancer activity, 9-(N-piperazinyl)-5-methyl-12(H)-q…
View article: Synthesis and Structure of 5-Methyl-9-(trifluoromethyl)-12H-quino[3,4-b][1,4]benzothiazinium Chloride as Anticancer Agent
Synthesis and Structure of 5-Methyl-9-(trifluoromethyl)-12H-quino[3,4-b][1,4]benzothiazinium Chloride as Anticancer Agent Open
In this work, the synthesis, structural analysis and anticancer properties of 5-methyl-9-trifluoromethyl-12H-quino[3,4-b][1,4]benzothiazinium chloride (3) are described. Compound 3 was synthesized by reacting 1-methyl-4-butylthio-3-(benzoy…
View article: Complex dielectric response and EDL characteristics of different types of ionic liquid iron oxide nanofluids (ionanofluids)
Complex dielectric response and EDL characteristics of different types of ionic liquid iron oxide nanofluids (ionanofluids) Open
Ionic liquid based magnetic nanofuids (ILMFs), an important subclass of ‘IoNanofuids’, have promising prospectus in numerous technological fields. Herein, we have investigated on the dielectric response and ac conductance behaviour of 1 wt…
View article: Towards Anticancer and Antibacterial Agents: Design and Synthesis of 1,2,3-Triazol-quinobenzothiazine Derivatives
Towards Anticancer and Antibacterial Agents: Design and Synthesis of 1,2,3-Triazol-quinobenzothiazine Derivatives Open
In this paper, we describe a new method for synthesizing hybrid combinations of 1,2,3-triazoles with a tetracyclic quinobenzothiazinium system. The developed approach allowed for the production of a series of new azaphenothiazine derivativ…
View article: From Design to Study of Liposome-Driven Drug Release Part 1: Impact of Temperature and pH on Environment
From Design to Study of Liposome-Driven Drug Release Part 1: Impact of Temperature and pH on Environment Open
The marketed drug Doxorubicin (DOX) and the promising anti-cancer agent 9-(N-piperazinyl)-5-methyl-12(H)-quino[3,4-b][1,4]benzothiazinium chloride (9-PBThACl) were used to prepare and compare a range of liposomal delivery systems based on …
View article: Towards Symmetric Thioamides: Microwave-Aided Synthesis of Terephthalic Acid Derivatives
Towards Symmetric Thioamides: Microwave-Aided Synthesis of Terephthalic Acid Derivatives Open
The multistep synthesis of novel bis-terephthalthioamides based on methyl esters of amino acids (AAs) was proposed using conventional heating and microwave-assisted approaches. In fact, the comparative case study on the thionation of new s…
View article: Anticancer Efficacy of Antibacterial Quinobenzothiazines
Anticancer Efficacy of Antibacterial Quinobenzothiazines Open
The antitumor potency of a series of designed and prepared antibacterial quinobenzothiazines was evaluated against different types of human cancer cell lines, such as glioblastoma SNB-19, lung adenocarcinoma A549 and breast cancer T47D, an…
View article: Towards Arginase Inhibition: Hybrid SAR Protocol for Property Mapping of Chlorinated N-arylcinnamamides
Towards Arginase Inhibition: Hybrid SAR Protocol for Property Mapping of Chlorinated N-arylcinnamamides Open
A series of seventeen 4-chlorocinnamanilides and seventeen 3,4-dichlorocinnamanilides were characterized for their antiplasmodial activity. In vitro screening on a chloroquine-sensitive strain of Plasmodium falciparum 3D7/MRA-102 highlight…
View article: Design, Synthesis and Antimicrobial Properties of New Tetracyclic Quinobenzothiazine Derivatives
Design, Synthesis and Antimicrobial Properties of New Tetracyclic Quinobenzothiazine Derivatives Open
A new method for modifying the structure of tetracyclic quinobenzothiazinium derivatives has been developed, allowing introduction of various substituents at different positions of the benzene ring. The method consists of reacting appropri…
View article: Chemistry towards Biology—Instruct: Snapshot
Chemistry towards Biology—Instruct: Snapshot Open
The knowledge of interactions between different molecules is undoubtedly the driving force of all contemporary biomedical and biological sciences. Chemical biology/biological chemistry has become an important multidisciplinary bridge conne…
View article: Clean Coal Technologies as an Effective Way in Global Carbon Dioxide Mitigation
Clean Coal Technologies as an Effective Way in Global Carbon Dioxide Mitigation Open
Energy security is a main challenge in today’s economies [...]
View article: A Generalized View of Longwall Emergency Stop Prevention (Ukraine)
A Generalized View of Longwall Emergency Stop Prevention (Ukraine) Open
Based on both theoretical and practical experiences, the measures aimed at controlling emergency shutdowns of stopes have been highlighted. These stopes are connected with the emergency rigid settlements of powered complexes. In terms of t…
View article: Towards Property Profiling: SYNTHESIS and SAR Probing of New Tetracyclic Diazaphenothiazine Analogues
Towards Property Profiling: SYNTHESIS and SAR Probing of New Tetracyclic Diazaphenothiazine Analogues Open
A series of new tertiary phenothiazine derivatives containing a quinoline and a pyridine fragment was synthesized by the reaction of 1-methyl-3-benzoylthio-4-butylthioquinolinium chloride with 3-aminopyridine derivatives bearing various su…
View article: CFD Numerical Modelling of a PV–TEG Hybrid System Cooled by Air Heat Sink Coupled with a Single-Phase Inverter
CFD Numerical Modelling of a PV–TEG Hybrid System Cooled by Air Heat Sink Coupled with a Single-Phase Inverter Open
This study presents full transient, three-dimensional numerical models of a PV–TEG hybrid module coupled with single-phase inverter by co-simulation. The influence of factors, such as wind speed, solar radiation intensity, or ambient tempe…
View article: Two Decades of 4D-QSAR: A Dying Art or Staging a Comeback?
Two Decades of 4D-QSAR: A Dying Art or Staging a Comeback? Open
A key question confronting computational chemists concerns the preferable ligand geometry that fits complementarily into the receptor pocket. Typically, the postulated ‘bioactive’ 3D ligand conformation is constructed as a ‘sophisticated g…
View article: Synthesis and Hybrid SAR Property Modeling of Novel Cholinesterase Inhibitors
Synthesis and Hybrid SAR Property Modeling of Novel Cholinesterase Inhibitors Open
A library of novel 4-{[(benzyloxy)carbonyl]amino}-2-hydroxybenzoic acid amides was designed and synthesized in order to provide potential acetyl- and butyrylcholinesterase (AChE/BChE) inhibitors; the in vitro inhibitory profile and selecti…
View article: Design, Synthesis, and Evaluation of Novel 3-Carboranyl-1,8-Naphthalimide Derivatives as Potential Anticancer Agents
Design, Synthesis, and Evaluation of Novel 3-Carboranyl-1,8-Naphthalimide Derivatives as Potential Anticancer Agents Open
We synthesized a series of novel 3-carboranyl-1,8-naphthalimide derivatives, mitonafide and pinafide analogs, using click chemistry, reductive amination and amidation reactions and investigated their in vitro effects on cytotoxicity, cell …
View article: Removal of Heavy Metal Ions from Wastewaters: An Application of Sodium Trithiocarbonate and Wastewater Toxicity Assessment
Removal of Heavy Metal Ions from Wastewaters: An Application of Sodium Trithiocarbonate and Wastewater Toxicity Assessment Open
The synthesis and application of sodium trithiocarbonate (Na2CS3) for the treatment of real galvanic wastewater in order to remove heavy metals (Cu, Cd and Zn) was investigated. A Central Composite Design/Response Surface Methodology (CCD/…
View article: Emission and Neutralization of Methane from a Municipal Landfill-Parametric Analysis
Emission and Neutralization of Methane from a Municipal Landfill-Parametric Analysis Open
An attempt was made to estimate the annual production of CH4 at a municipal waste landfill site in Poland. As a matter of fact, the extent of the unorganized emission of CH4 from the landfill surface was approached based on the adopted mat…
View article: Potassium Ferrate (VI) as the Multifunctional Agent in the Treatment of Landfill Leachate
Potassium Ferrate (VI) as the Multifunctional Agent in the Treatment of Landfill Leachate Open
Possible use of potassium ferrate (VI) (K2FeO4) for the treatment of landfill leachate (pH = 8.9, Chemical Oxygen Demand (COD) 770 mg O2/L, Total Organic Carbon (TOC) 230 mg/L, Total Nitrogen (Total N) 120 mg/L, Total Phosphorus (Total P) …
View article: Estimation of Dense Plasma Temperature Formed under Shock Wave Cumulation
Estimation of Dense Plasma Temperature Formed under Shock Wave Cumulation Open
The research was carried out by means of implosion plasma generators with conical and hemispherical compression chambers to conduct a quantitative assessment of the boundary temperature of super dense plasma jets. It was proved experimenta…
View article: Biological Activities and ADMET-Related Properties of Novel Set of Cinnamanilides
Biological Activities and ADMET-Related Properties of Novel Set of Cinnamanilides Open
A series of nineteen novel ring-substituted N-arylcinnamanilides was synthesized and characterized. All investigated compounds were tested against Staphylococcus aureus as the reference strain, two clinical isolates of methicillin-resistan…
View article: Consensus-Based Pharmacophore Mapping for New Set of N-(disubstituted-phenyl)-3-hydroxyl-naphthalene-2-carboxamides
Consensus-Based Pharmacophore Mapping for New Set of N-(disubstituted-phenyl)-3-hydroxyl-naphthalene-2-carboxamides Open
A series of twenty-two novel N-(disubstituted-phenyl)-3-hydroxynaphthalene- 2-carboxamide derivatives was synthesized and characterized as potential antimicrobial agents. N-[3,5-bis(trifluoromethyl)phenyl]- and N-[2-chloro-5-(trifluorometh…
View article: Water-Induced Corrosion Damage of Carbon Steel in Sulfolane
Water-Induced Corrosion Damage of Carbon Steel in Sulfolane Open
Sulfolane in contact with water and oxygen forms acidic (by-) products that are major factors in accelerating the corrosion of carbon/stainless steel. In consequence, water-induced corrosion damage can be a serious problem in industrial sy…
View article: A Study of Heat Exchange Processes within the Channels of Disk Pulse Devices
A Study of Heat Exchange Processes within the Channels of Disk Pulse Devices Open
The effect of basic parameters of the channels of disk pulse devices on the heat exchange efficiency was studied both analytically and experimentally, especially in terms of pulse acting on the heat carrier. A methodology to determine the …
View article: A study on the static field of a point charge in three-dimensional electrodynamics
A study on the static field of a point charge in three-dimensional electrodynamics Open
The static field potential in quantum electrodynamics in the space of three dimensions (QED 3 ) produced by a point charge was investigated taking into account the polarization of the vacuum. The polarization operator is taken in the …
View article: Temperature-Related Corrosion Resistance of AISI 1010 Carbon Steel in Sulfolane
Temperature-Related Corrosion Resistance of AISI 1010 Carbon Steel in Sulfolane Open
Sulfolane-induced corrosion can lead to severe impairment in industrial systems. Therefore, determination of solvent corrosivity is valid. Under standard conditions, pure sulfolane is considered to be thermally stable and chemically inert,…
View article: Taguchi Method and Response Surface Methodology in the Treatment of Highly Contaminated Tannery Wastewater Using Commercial Potassium Ferrate
Taguchi Method and Response Surface Methodology in the Treatment of Highly Contaminated Tannery Wastewater Using Commercial Potassium Ferrate Open
The potential implementation of Envifer®, a commercial product containing potassium ferrate (40.1% K2FeO4), for the purification of highly contaminated tannery wastewater from leather dyeing processes was proposed. The employment of the Ta…