Andrzej Bartke
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View article: Surgical Removal of Visceral Adipose Tissue has Therapeutic Benefit in Male APP<sup>NL-F</sup> Mice
Surgical Removal of Visceral Adipose Tissue has Therapeutic Benefit in Male APP<sup>NL-F</sup> Mice Open
Purpose Visceral white adipose tissue (vWAT) accumulation causes systemic inflammation, insulin resistance, metabolic syndrome, and senescent cell accumulation that are risk factors for Alzheimer’s disease (AD). Visceral fat removal (VFR) …
View article: Thermotherapy has sexually dimorphic responses in APP/PS1 mice
Thermotherapy has sexually dimorphic responses in APP/PS1 mice Open
A thermoregulatory decline occurs with age due to changes in muscle mass, vasoconstriction, and metabolism that lowers core body temperature (Tc). Although lower Tc is a biomarker of successful aging, we have previously shown this worsens …
View article: Lifespan of male and female APP/PS1 and APP<sup>NL-F/NL-F</sup>mouse models of Alzheimer’s disease
Lifespan of male and female APP/PS1 and APP<sup>NL-F/NL-F</sup>mouse models of Alzheimer’s disease Open
Alzheimer’s disease (AD) disproportionately affects women, yet most preclinical research studies are male-centric. We performed lifespan analyses of male and female AD mouse models (APP/PS1 and APP NL-F/NL-F ) and their shared genetic back…
View article: ERRATUM: GH modulates hepatic epidermal growth factor signaling in the mouse
ERRATUM: GH modulates hepatic epidermal growth factor signaling in the mouse Open
View article: Thermotherapy has Sexually Dimorphic Responses in APP/PS1 Mice
Thermotherapy has Sexually Dimorphic Responses in APP/PS1 Mice Open
A thermoregulatory decline occurs with age due to changes in muscle mass, vasoconstriction, and metabolism that lowers core body temperature (Tc). Although lower Tc is a biomarker of successful aging, we have previously shown this worsens …
View article: Early Life Interventions: Impact on Aging and Longevity
Early Life Interventions: Impact on Aging and Longevity Open
Across mammals, lifespans vary remarkably, spanning over a hundredfold difference. Comparative studies consistently reveal a strong inverse relationship between developmental pace and lifespan, hinting at the potential for early-life inter…
View article: Senolytic Intervention Improves Cognition, Metabolism, and Adiposity in Female APP<sup>NL-F/NL-F</sup>Mice
Senolytic Intervention Improves Cognition, Metabolism, and Adiposity in Female APP<sup>NL-F/NL-F</sup>Mice Open
Senescent cells accumulate throughout the body and brain contributing to unhealthy aging and Alzheimer’s disease (AD). The APP NL-F/NL-F amyloidogenic AD mouse model exhibits increased markers of senescent cells and the senescence-associat…
View article: ANTIDIABETIC THERAPIES METFORMIN AND TRODUSQUEMINE MODULATE MIRNAS INVOLVED WITH LIVER METABOLISM
ANTIDIABETIC THERAPIES METFORMIN AND TRODUSQUEMINE MODULATE MIRNAS INVOLVED WITH LIVER METABOLISM Open
Type II diabetes mellitus (T2DM) afflicts approximately 33% of individuals over the age of 65 increasing susceptibility to dyslipidemia, a hallmark of non-alcoholic fatty liver disease (NAFLD). Due to the idiopathic nature of NAFLD, there …
View article: INVESTIGATING THE IMPACTS OF METFORMIN ON AGING AND LIFESPAN IN DIVERSITY OUTBRED MICE
INVESTIGATING THE IMPACTS OF METFORMIN ON AGING AND LIFESPAN IN DIVERSITY OUTBRED MICE Open
Metformin, a type 2 diabetes treatment, has profound effects on regulating development, metabolism, and aging acting via the mTOR/autophagy pathway. Nevertheless, its potential to extend lifespan and counteract aging remains an open questi…
View article: Relationships among Development, Growth, Body Size, Reproduction, Aging, and Longevity – Trade-Offs and Pace-Of-Life
Relationships among Development, Growth, Body Size, Reproduction, Aging, and Longevity – Trade-Offs and Pace-Of-Life Open
Relationships of growth, metabolism, reproduction, and body size to the biological process of aging and longevity have been studied for decades and various unifying “theories of aging” have been proposed to account for the observed associa…
View article: THU297 Metformin Treatment Of Juvenile Mice Alters Aging-Related Developmental And Metabolic Phenotypes In Sex-Dependent And -Independent Manners
THU297 Metformin Treatment Of Juvenile Mice Alters Aging-Related Developmental And Metabolic Phenotypes In Sex-Dependent And -Independent Manners Open
Disclosure: Y. Zhu: None. M. Engmann: None. D. Medina: None. A. Bartke: None. B.S. Ellsworth: None. R. Yuan: None. Metformin is a widely used drug for the treatment of type 2 diabetes that also has a strong potential for long-term effects …
View article: Decreased IGF1R attenuates senescence and improves function in pancreatic β-cells
Decreased IGF1R attenuates senescence and improves function in pancreatic β-cells Open
Introduction The enhanced β-cell senescence that accompanies insulin resistance and aging contributes to cellular dysfunction and loss of transcriptional identity leading to type 2 diabetes (T2D). While senescence is among the 12 recognize…
View article: Prodromal Glutamatergic Modulation with Riluzole Impacts Glucose Homeostasis and Spatial Cognition in Alzheimer’s Disease Mice
Prodromal Glutamatergic Modulation with Riluzole Impacts Glucose Homeostasis and Spatial Cognition in Alzheimer’s Disease Mice Open
Background: Prior research supports a strong link between Alzheimer’s disease (AD) and metabolic dysfunction that involves a multi-directional interaction between glucose, glutamatergic homeostasis, and amyloid pathology. Elevated soluble …
View article: Erratum
Erratum Open
View article: P- 11 PROTUMORIGENIC GALECTINS 1 AND 3 ARE UPREGULATED IN THE LIVER OF MICE EXPOSED TO CONTINUOUS GROWTH HORMONE LEVELS
P- 11 PROTUMORIGENIC GALECTINS 1 AND 3 ARE UPREGULATED IN THE LIVER OF MICE EXPOSED TO CONTINUOUS GROWTH HORMONE LEVELS Open
Introduction and Objectives: Human and animal evidence revealed a link between growth hormone (GH) and cancer risk. GH excess is implicated in rodent hepatocarcinogenesis. Transgenic mice overexpressing GH (GH-Tg) develop hepatocellular tu…
View article: Growth hormone receptor (GHR) in AgRP neurons regulates thermogenesis in aged mice in a sex-specific manner
Growth hormone receptor (GHR) in AgRP neurons regulates thermogenesis in aged mice in a sex-specific manner Open
Evidence for hypothalamic regulation of energy homeostasis and thermoregulation in brown adipose tissue (BAT) during aging has been well recognized, yet the central molecular mediators involved in this process are poorly understood. The ar…
View article: Friend or Foe? Defining the Role of Glutamate in Aging and Alzheimer’s Disease
Friend or Foe? Defining the Role of Glutamate in Aging and Alzheimer’s Disease Open
Aging is a naturally occurring decline of physiological processes and biological pathways that affects both the structural and functional integrity of the body and brain. These physiological changes reduce motor skills, executive function,…
View article: Insulin signaling in the heart is impaired by growth hormone: a direct and early event
Insulin signaling in the heart is impaired by growth hormone: a direct and early event Open
Growth hormone (GH) exerts major actions in cardiac growth and metabolism. Considering the important role of insulin in the heart and the well-established anti-insulin effects of GH, cardiac insulin resistance may play a role in the cardio…
View article: Early Life Interventions Can Shape Aging
Early Life Interventions Can Shape Aging Open
It is well documented that the environment of the developing fetus, including availability of nutrients and presence of toxins, can have major impact on adult phenotype, age-related traits and risk of chronic disease. There is also accumul…
View article: New Directions in Research on Aging
New Directions in Research on Aging Open
View article: Metformin treatment of juvenile mice alters aging-related developmental and metabolic phenotypes
Metformin treatment of juvenile mice alters aging-related developmental and metabolic phenotypes Open
View article: Sexual Dimorphic Metabolic and Cognitive Responses of C57BL/6 Mice to Fisetin or Dasatinib and Quercetin Cocktail Oral Treatment
Sexual Dimorphic Metabolic and Cognitive Responses of C57BL/6 Mice to Fisetin or Dasatinib and Quercetin Cocktail Oral Treatment Open
Senolytic treatment in aged mice clears senescent cell burden leading to functional improvements. However, less is known regarding the effects of these compounds when administered prior to significant senescent cell accumulation. From 4-13…
View article: Benefits of Living Without Growth Hormone
Benefits of Living Without Growth Hormone Open
Benefits of Living Without Growth Hormone Andrzej Bartke, PhD, FGSA Andrzej Bartke, PhD, FGSA Department of Internal Medicine, Southern Illinois University School of Medicine, Springfield, USA Address correspondence to: Andrzej Bartke, PhD…
View article: Clustered Mendelian Randomization analyses identifies distinct and opposing pathways in the causal association between insulin-like growth factor-1 and type 2 diabetes mellitus
Clustered Mendelian Randomization analyses identifies distinct and opposing pathways in the causal association between insulin-like growth factor-1 and type 2 diabetes mellitus Open
Aims/hypothesis There is inconsistent evidence for the causal role of serum insulin-like growth factor-1 (IGF-1) concentration in the pathogenesis of type 2 diabetes. Here, we investigated the association between IGF-1 and type 2 diabetes …
View article: Growth hormone upregulates the pro-tumorigenic galectin 1 in mouse liver
Growth hormone upregulates the pro-tumorigenic galectin 1 in mouse liver Open
View article: Growth Hormone and Aging: New Findings
Growth Hormone and Aging: New Findings Open
Complex relationships between growth hormone (GH) signaling and mammalian aging continue to attract attention of many investigators. Recent results include evidence that the impact of GH on genome maintenance (DNA damage and repair) is dra…
View article: The effects of early-life growth hormone intervention on tissue specific histone H3 modifications in long-lived Ames dwarf mice
The effects of early-life growth hormone intervention on tissue specific histone H3 modifications in long-lived Ames dwarf mice Open
Histone modifications, specifically in the lysine residues of histone H3, have been implicated in lifespan regulation in several model organisms. Our previous studies showed that growth hormone (GH) treatment during early life can dramatic…
View article: Alzheimer’s disease‐related sex differences in insulin sensitivity, glucose metabolism, and spatial memory
Alzheimer’s disease‐related sex differences in insulin sensitivity, glucose metabolism, and spatial memory Open
Background Women are at higher risk for developing Alzheimer’s disease (AD), comprising two‐thirds of AD patients. In this study, we aimed to characterize AD‐related sex differences in insulin sensitivity, glucose tolerance, and spatial le…
View article: Growth hormone and aging: focus on healthspan
Growth hormone and aging: focus on healthspan Open
View article: Issue Information
Issue Information Open