Andrzej Miklaszewski
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View article: Chitosan/PEO Nanofibers as a Delivery Platform for Sustained Release of Centella asiatica Extract
Chitosan/PEO Nanofibers as a Delivery Platform for Sustained Release of Centella asiatica Extract Open
The search for multifunctional wound dressings that combine structural integrity with biological activity remains an important challenge in modern biomedicine. In this study, electrospun chitosan/polyethylene oxide (CS/PEO) nanofibers inco…
View article: Elderberry-Based Multifunctional Prebiotic Systems Prepared via Spray Drying
Elderberry-Based Multifunctional Prebiotic Systems Prepared via Spray Drying Open
Elderberry (Sambucus nigra L.) is recognized as a rich source of anthocyanins and other bioactives with antioxidant and antidiabetic potential, and is increasingly explored as a functional ingredient in nutraceuticals. However, cultivar-de…
View article: Cyclodextrin/PVP-Based Nanofibers with Rhadiola rosea Extract as a New System for Increasing Bioavailability of Active Components
Cyclodextrin/PVP-Based Nanofibers with Rhadiola rosea Extract as a New System for Increasing Bioavailability of Active Components Open
The present study aimed to optimize the extraction process for Rhodiola rosea root, then develop and optimize electrospun nanofiber systems containing extract to enhance the bioavailability of its active compounds, salidroside and rosarin.…
View article: Baicalein-Loaded Chitosan Films for Local Treatment of Oral Infections
Baicalein-Loaded Chitosan Films for Local Treatment of Oral Infections Open
Oral infections and tissue defects remain significant clinical challenges, often requiring localized, sustained, and multifunctional therapeutic solutions. In this study, baicalein-loaded chitosan films were developed and comprehensively c…
View article: Cyclodextrin-Based Systems of Cetraria islandica Extracts: A Novel Approach to Improve Solubility and Biological Activity of Lichen-Derived Natural Products
Cyclodextrin-Based Systems of Cetraria islandica Extracts: A Novel Approach to Improve Solubility and Biological Activity of Lichen-Derived Natural Products Open
Cetraria islandica (L.) Ach. (CI) is a lichen from the Parmeliaceaea family used in medicine. However, the low solubility of CI secondary metabolites in water limits the application of lichen extract and compounds. It prompted us to study …
View article: Azithromycin-Loaded Nanoparticles Incorporated in Chitosan-Based Soft Hydrogels: A Novel Approach for Dental Drug Delivery
Azithromycin-Loaded Nanoparticles Incorporated in Chitosan-Based Soft Hydrogels: A Novel Approach for Dental Drug Delivery Open
Background: Azithromycin (AZC), a BCS class II/IV antibiotic with broad-spectrum antimicrobial activity, has poor water solubility, limiting its formulation potential. This study aimed to develop and optimize AZC-based soft hydrogels for t…
View article: Enhancing the Solubility and Dissolution of Apigenin: Solid Dispersions Approach
Enhancing the Solubility and Dissolution of Apigenin: Solid Dispersions Approach Open
Apigenin (APG), a bioactive flavonoid with promising therapeutic potential, suffers from poor water solubility, which limits its bioavailability. To address this, solid dispersions of APG were prepared using ball milling with sodium algina…
View article: Ashwagandha: Optimizing the Extraction and Electrospun Nanofiber Production
Ashwagandha: Optimizing the Extraction and Electrospun Nanofiber Production Open
Background/Objectives: This study explores the development of electrospun nanofibers incorporating bioactive compounds from Withania somnifera (Ashwagandha) root extract, focusing on optimizing extraction conditions and nanofiber compositi…
View article: Recycling of HDPE-giant reed composites: Processability and performance
Recycling of HDPE-giant reed composites: Processability and performance Open
Giant reed ( Arundo donax ), a plant species with potential for obtaining lignocellulosic fibres, was validated as reinforcement in thermoplastic composites with good processability, thermo-mechanical performance, and aesthetics. This stud…
View article: Application of the Box–Behnken Design in the Development of Amorphous PVP K30–Phosphatidylcholine Dispersions for the Co-Delivery of Curcumin and Hesperetin Prepared by Hot-Melt Extrusion
Application of the Box–Behnken Design in the Development of Amorphous PVP K30–Phosphatidylcholine Dispersions for the Co-Delivery of Curcumin and Hesperetin Prepared by Hot-Melt Extrusion Open
Background: Curcumin and hesperetin are plant polyphenols known for their poor solubility. To address this limitation, we prepared amorphous PVP K30–phosphatidylcholine dispersions via hot-melt extrusion. Methods: This study aimed to evalu…
View article: The Influence of Horsetail (Equisetum arvense L.) Powder and Horsetail-Based Silica on the Crystallization Kinetics of Polylactide
The Influence of Horsetail (Equisetum arvense L.) Powder and Horsetail-Based Silica on the Crystallization Kinetics of Polylactide Open
Biogenic silica (SiO2) sourced from living organisms, especially plants such as rice and other cereals, has recently been successfully applied in different polymeric compositions. Another rich source of biogenic silica is common horsetail …
View article: The Effect of Laponite on the Structure, Mechanical and Thermal Properties of Poly(butylene Succinate)
The Effect of Laponite on the Structure, Mechanical and Thermal Properties of Poly(butylene Succinate) Open
The comparison of some changes occurring in the physical properties of poly(butylene succinate) (PBS) due to its modification with Laponite (LAP) was the objective of this study. The PBS composites, containing from 1 to 7 wt% LAP, were pre…
View article: Amorphous Polymer–Phospholipid Solid Dispersions for the Co-Delivery of Curcumin and Piperine Prepared via Hot-Melt Extrusion
Amorphous Polymer–Phospholipid Solid Dispersions for the Co-Delivery of Curcumin and Piperine Prepared via Hot-Melt Extrusion Open
Curcumin and piperine are plant compounds known for their health-promoting properties, but their use in the prevention or treatment of various diseases is limited by their poor solubility. To overcome this drawback, the curcumin–piperine a…
View article: Electrospun Nanofibers with Pomegranate Peel Extract as a New Concept for Treating Oral Infections
Electrospun Nanofibers with Pomegranate Peel Extract as a New Concept for Treating Oral Infections Open
Pomegranate peel extract is known for its potent antibacterial, antiviral, antioxidant, anti-inflammatory, wound healing, and probiotic properties, leading to its use in treating oral infections. In the first stage of this work, for the fi…
View article: Sweeteners Show a Plasticizing Effect on PVP K30—A Solution for the Hot-Melt Extrusion of Fixed-Dose Amorphous Curcumin-Hesperetin Solid Dispersions
Sweeteners Show a Plasticizing Effect on PVP K30—A Solution for the Hot-Melt Extrusion of Fixed-Dose Amorphous Curcumin-Hesperetin Solid Dispersions Open
The co-administration of curcumin and hesperetin might be beneficial in terms of neuroprotective activity; therefore, in this study, we attempted to develop a fixed-dose formulation comprising these two compounds in an amorphous state. The…
View article: Heat treatment effects on tribocorrosion resistance of Inconel 718® alloy produced by conventional and laser powder bed fusion methods
Heat treatment effects on tribocorrosion resistance of Inconel 718® alloy produced by conventional and laser powder bed fusion methods Open
The article presents a study of the tribocorrosion phenomenon and its effects on Inconel 718 alloy produced conventionally by extrusion and additively manufactured using the laser powder bed fusion method. In addition, the samples were sub…
View article: Prebiotic Systems Containing Anthocyanin-Rich Pomegranate Flower Extracts with Antioxidant and Antidiabetic Effects
Prebiotic Systems Containing Anthocyanin-Rich Pomegranate Flower Extracts with Antioxidant and Antidiabetic Effects Open
Pomegranate flower extract, rich in anthocyanins, demonstrates beneficial health-promoting properties such as an anti-diabetic and antioxidant effect, among others. However, the potential health-promoting properties may be hindered by the …
View article: Electrospun Nanofibers Loaded with Marigold Extract Based on PVP/HPβCD and PCL/PVP Scaffolds for Wound Healing Applications
Electrospun Nanofibers Loaded with Marigold Extract Based on PVP/HPβCD and PCL/PVP Scaffolds for Wound Healing Applications Open
Marigold flower is a traditionally used plant material topically applied on the skin due to its anti-inflammatory properties and antibacterial activity. This potential of action justifies the implementation of marigold extract in nanofiber…
View article: 3D-Printed Chitosan-Based Scaffolds with Scutellariae baicalensis Extract for Dental Applications
3D-Printed Chitosan-Based Scaffolds with Scutellariae baicalensis Extract for Dental Applications Open
The plant material Scutellariae baicalensis radix, which is rich in flavones (baicalin), possesses antibacterial, antifungal, antioxidant, and anti-inflammatory properties. This work aimed to develop a 3D-printed chitosan-based hydrogel ri…
View article: Investigation of cyclodextrin as potential carrier for lycopene
Investigation of cyclodextrin as potential carrier for lycopene Open
Lycopene is a carotenoid with high antioxidant activity. Numerous studies show its positive effects in the prevention and amelioration of many diseases. However, due to its lack of water solubility, its use is very limited. Developing a fo…
View article: Preparation of Thin Films Containing Modified Hydroxyapatite Particles and Phospholipids (DPPC) for Improved Properties of Biomaterials
Preparation of Thin Films Containing Modified Hydroxyapatite Particles and Phospholipids (DPPC) for Improved Properties of Biomaterials Open
The main aims of thin biofilm synthesis are to either achieve a new form to promote the transport of drugs in oral delivery systems or as a coating to improve the biocompatibility of the implant’s surface. In this study, the Langmuir monol…
View article: Study of montmorillonite modification technology using polyvinylpyrrolidone
Study of montmorillonite modification technology using polyvinylpyrrolidone Open
In this work, a new method of modifying montmorillonite (Mt) with polyvinylpyrrolidone (PVP) was developed, which makes it possible to obtain modified Mt with different structures and modifier content simultaneously. The essence of the met…
View article: The Antioxidant Potential of Resveratrol from Red Vine Leaves Delivered in an Electrospun Nanofiber System
The Antioxidant Potential of Resveratrol from Red Vine Leaves Delivered in an Electrospun Nanofiber System Open
Despite the wide pharmacological action of polyphenols, their usefulness is limited due to their low oral bioavailability, which is due to their low solubility and rapid first-pass metabolism. Red vine leaf extract is an herbal medicine co…
View article: Hot Melt Extrusion for Improving the Physicochemical Properties of Polydatin Derived from Polygoni cuspidati Extract; A Solution Recommended for Buccal Applications
Hot Melt Extrusion for Improving the Physicochemical Properties of Polydatin Derived from Polygoni cuspidati Extract; A Solution Recommended for Buccal Applications Open
Three different types of solid dispersions based on polyvinyl polymers and related copolymers (Kollidon® VA64, Soluplus® and Kollicoat IR®) comprising polydatin-rich Polygoni cuspidati extract were prepared by hot melt extrusion. The syste…
View article: Zein as an Effective Carrier for Hesperidin Delivery Systems with Improved Prebiotic Potential
Zein as an Effective Carrier for Hesperidin Delivery Systems with Improved Prebiotic Potential Open
Hesperidin is a polyphenol derived from citrus fruits that has a broad potential for biological activity and the ability to positively modify the intestinal microbiome. However, its activity is limited by its low solubility and, thus, its …
View article: Screening of the Anti-Neurodegenerative Activity of Caffeic Acid after Introduction into Inorganic Metal Delivery Systems to Increase Its Solubility as the Result of a Mechanosynthetic Approach
Screening of the Anti-Neurodegenerative Activity of Caffeic Acid after Introduction into Inorganic Metal Delivery Systems to Increase Its Solubility as the Result of a Mechanosynthetic Approach Open
The proven anti-neurodegenerative properties of caffeic acid in vivo are limited due to its poor solubility, which limits bioavailability. Therefore, caffeic acid delivery systems have been developed to improve caffeic acid solubility. Sol…
View article: Improving Solubility and Permeability of Hesperidin through Electrospun Orange-Peel-Extract-Loaded Nanofibers
Improving Solubility and Permeability of Hesperidin through Electrospun Orange-Peel-Extract-Loaded Nanofibers Open
Orange peel, which is a rich source of polyphenolic compounds, including hesperidin, is produced as waste in production. Therefore, optimization of the extraction of hesperidin was performed to obtain its highest content. The influence of …
View article: Review of: "Hydroxyapatite coating techniques for Titanium Dental Implants — an overview"
Review of: "Hydroxyapatite coating techniques for Titanium Dental Implants — an overview" Open
Potential competing interests: No potential competing
View article: Hot Melt Extrusion as an Effective Process in the Development of Mucoadhesive Tablets Containing Scutellariae baicalensis radix Extract and Chitosan Dedicated to the Treatment of Oral Infections
Hot Melt Extrusion as an Effective Process in the Development of Mucoadhesive Tablets Containing Scutellariae baicalensis radix Extract and Chitosan Dedicated to the Treatment of Oral Infections Open
Hot Melt Extrusion (HME) technology was developed to obtain blends containing lyophilized Scutellariae baicalensis root extract and chitosan in order to improve the rheological properties of the obtained blends, including tableting and com…