Andrzej Mular
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View article: Biomimetic Analogues of the Desferrioxamine E Siderophore for PET Imaging of Invasive Aspergillosis: Targeting Properties and Species Specificity
Biomimetic Analogues of the Desferrioxamine E Siderophore for PET Imaging of Invasive Aspergillosis: Targeting Properties and Species Specificity Open
The pathogenic fungus Aspergillus fumigatus utilizes a cyclic ferrioxamine E (FOXE) siderophore to acquire iron from the host. Biomimetic FOXE analogues were labeled with gallium-68 for molecular imaging with PET. [68Ga]Ga(III)-FOXE analog…
View article: The diversity and utility of arylthiazoline and aryloxazoline siderophores: Challenges of coordination chemistry, biological activity and selected applications
The diversity and utility of arylthiazoline and aryloxazoline siderophores: Challenges of coordination chemistry, biological activity and selected applications Open
One of the factors necessary for the survivability and growth of microorganisms are iron ions. For the uptake of this vital metal ion from the surrounding environment, microorganisms have evolved a system which employs low-molecular mass, …
View article: BAKTERYJNE STRATEGIE WYKORZYSTANIA JONÓW METALI – KULISY CHEMII KOORDYNACYJNEJ
BAKTERYJNE STRATEGIE WYKORZYSTANIA JONÓW METALI – KULISY CHEMII KOORDYNACYJNEJ Open
In the Biological Inorganic Chemistry Group we are inspired to better understand metal ions acquisition and homeostasis in pathogenic bacteria, and in this review we present three different approaches to the role of these processes. The gr…
View article: The diversity and utility of arylthiazoline and aryloxazoline siderophores: challenges of total synthesis
The diversity and utility of arylthiazoline and aryloxazoline siderophores: challenges of total synthesis Open
A review presents advances in total synthesis of thiazoline and oxazoline-bearing siderophores, unique ferric ion chelators found in some bacteria, fungi and plants.
View article: Cyclic Analogs of Desferrioxamine E Siderophore for <sup>68</sup>Ga Nuclear Imaging: Coordination Chemistry and Biological Activity in <i>Staphylococcus aureus</i>
Cyclic Analogs of Desferrioxamine E Siderophore for <sup>68</sup>Ga Nuclear Imaging: Coordination Chemistry and Biological Activity in <i>Staphylococcus aureus</i> Open
As multidrug-resistant bacteria are an emerging problem and threat to humanity, novel strategies for treatment and diagnostics are actively sought. We aim to utilize siderophores, iron-specific strong chelating agents produced by microbes,…
View article: Thermodynamic Stability and Speciation of Ga(III) and Zr(IV) Complexes with High-Denticity Hydroxamate Chelators
Thermodynamic Stability and Speciation of Ga(III) and Zr(IV) Complexes with High-Denticity Hydroxamate Chelators Open
Increasing attention has been recently devoted to 89Zr(IV) and 68Ga(III) radionuclides, due to their favorable decay characteristics for positron emission tomography (PET). In the present paper, a deep investigation is presented on Ga(III)…
View article: Synthesis and spectral characterization of the first fluorescein-tagged iron(<scp>ii</scp>) clathrochelates, their supramolecular interactions with globular proteins, and cellular uptake
Synthesis and spectral characterization of the first fluorescein-tagged iron(<span>ii</span>) clathrochelates, their supramolecular interactions with globular proteins, and cellular uptake Open
The fluorescein-tagged iron(ii) clathrochelate was synthesized for the first time and its accumulation in A2780 cancer cells was studied.