Explanipedia

Convergent Validity of Experimental Cognitive Tests in a Large Community Sample Open

Andy C. Dean, Jean-Baptiste Pochon, Robert M. Bilder, Fred W. Sabb, Eliza Congdon , et al. · 2024

Experimental cognitive tests are designed to measure particular cognitive domains, although evidence supporting test validity is often limited. The Consortium for Neuropsychiatric Phenomics test battery administered 23 experimental and tra…

Brain mGlu5 Is Linked to Cognition and Cigarette Smoking but Does Not Differ From Control in Early Abstinence From Chronic Methamphetamine Use Open

Megan N. McClintick, Robert Kessler, M. Mandelkern, Tarannom Mahmoudie, Daicia C. Allen , et al. · 2024

Background The group-I metabotropic glutamate receptor subtype 5 (mGlu5) has been implicated in methamphetamine exposure in animals and in human cognition. Because people with methamphetamine use disorder (MUD) exhibit cognitive deficits, …

Decomposing risky decision-making in methamphetamine use disorder: Behavioral updating and D2 dopamine receptors Open

Zoe Guttman, M. Mandelkern, Dara G. Ghahremani, Milky Kohno, Andy C. Dean , et al. · 2023

The findings indicate that behavioral updating contributes to maladaptive decision-making in MUD and suggest that dysregulation of D2-type receptor signaling in the striatum and globus pallidus contributes to this behavioral deficit.

Nicotine dependence and insula subregions: functional connectivity and cue-induced activation Open

Dara G. Ghahremani, Jean‐Baptiste Pochon, Maylen Perez Diaz, Rachel F. Tyndale, Andy C. Dean , et al. · 2023

Polygenic Contributions to Performance on the Balloon Analogue Risk Task Open

Erika L. Nurmi, Christopher Laughlin, Harriet de Wit, Abraham A. Palmer, James MacKillop , et al. · 2023

Risky decision-making is a common, heritable endophenotype seen across many psychiatric disorders. Its underlying genetic architecture is incompletely explored. We examined behavior in the Balloon Analogue Risk Task (BART), which tests ris…

Cortical thickness and related depressive symptoms in early abstinence from chronic methamphetamine use Open

Johannes Petzold, Andy C. Dean, Jean‐Baptiste Pochon, Dara G. Ghahremani, Richard De La Garza , et al. · 2022

Methamphetamine use is surging globally as a cause of morbidity and mortality. Treatment is typically sought in early abstinence, when craving and depressive symptoms are intense, contributing to relapse and poor outcomes. To advance an un…

Denial and Diagnosis of Methamphetamine Dependence Severity Open

Myra Rice, Andy C. Dean, Jaymee Suh, Edythe D. London · 2022

Introduction: Denial, or lack of awareness of problems related to substance misuse, is a common feature of drug use disorders and can affect engagement in treatment and recovery. This study tested for association of denial with severity of…

Age Influences Loss Aversion Through Effects on Posterior Cingulate Cortical Thickness Open

Zoe Guttman, Dara G. Ghahremani, Jean-Baptiste Pochon, Andy C. Dean, Edythe D. London · 2021

Decision-making strategies shift during normal aging and can profoundly affect wellbeing. Although overweighing losses compared to gains, termed “loss aversion,” plays an important role in choice selection, the age trajectory of this effec…

Functional connectivity of the anterior insula during withdrawal from cigarette smoking Open

Dara G. Ghahremani, Jean‐Baptiste Pochon, Maylen Perez Diaz, Rachel F. Tyndale, Andy C. Dean , et al. · 2021

Sex Differences in the Association of Cigarette Craving With Insula Structure Open

Maylen Perez Diaz, Jean‐Baptiste Pochon, Dara G. Ghahremani, Andy C. Dean, Paul Faulkner , et al. · 2021

Background Cigarette craving, which can negatively impact smoking cessation, is reportedly stronger in women than in men when they initiate abstinence from smoking. Identifying approaches to counteract craving in people of different sexes …

<i>CYP2D6</i> genotype may moderate measures of brain structure in methamphetamine users Open

Andy C. Dean, Erika L. Nurmi, Angelica M. Morales, Arthur K. Cho, Lauren C. Seaman , et al. · 2020

Chronic methamphetamine use is linked to abnormalities in brain structure, which may reflect neurotoxicity related to metabolism of the drug. As the cytochrome P450 2D6 (CYP2D6) enzyme is central to the metabolism of methamphetamine, genot…

Neural Basis of Smoking-Related Difficulties in Emotion Regulation Open

Paul Faulkner, Andy C. Dean, Dara G. Ghahremani, Edythe D. London · 2020

Background Negative emotional states contribute to cigarette smoking, and difficulties in regulating these states can hinder smoking cessation. Understanding the neural bases of these difficulties in smokers may facilitate development of n…

No effect of attentional bias modification training in methamphetamine users receiving residential treatment Open

Andy C. Dean, Erika L. Nurmi, Scott J. Moeller, Nader Amir, Michelle Rozenman , et al. · 2018

Cognitive deficit in methamphetamine users relative to childhood academic performance: link to cortical thickness Open

Andy C. Dean, Angelica M. Morales, Gerhard Hellemann, Edythe D. London · 2018

Increased self-reported impulsivity in methamphetamine users maintaining drug abstinence Open

Hannah W. Jones, Andy C. Dean, Kimberly A. Price, Edythe D. London · 2016

These findings suggest that methamphetamine users report more impulsivity when abstaining from drug use, an effect that is not significantly related to methamphetamine withdrawal. Attenuation of impulsivity may reinforce continued methamph…

Sex Differences in Midbrain Dopamine D2-Type Receptor Availability and Association with Nicotine Dependence Open

Kyoji Okita, Nicole Petersen, Chelsea L. Robertson, Andy C. Dean, M. Mandelkern , et al. · 2016

Emotion dysregulation and amygdala dopamine D2-type receptor availability in methamphetamine users Open

Kyoji Okita, Dara G. Ghahremani, Doris Payer, Chelsea L. Robertson, Andy C. Dean , et al. · 2016

Striatal Dopamine D2/D3 Receptor Availability Is Associated with Executive Function in Healthy Controls but Not Methamphetamine Users Open

Michael E. Ballard, Andy C. Dean, M. Mandelkern, Edythe D. London · 2015

These results suggest that cognitive flexibility, as measured by perseverative errors on the Wisconsin Card Sorting Test, is not determined by signaling through striatal D2/D3 receptors in healthy controls, and that in stimulant abusers, w…

Midbrain dopamine D2/D3 receptor availability and drug craving are associated with mesocorticolimbic gray matter volume in methamphetamine users Open

Angelica M. Morales, Milky Kohno, Chelsea L. Robertson, Andy C. Dean, M. Mandelkern , et al. · 2015

Gray-matter volume, midbrain dopamine D2/D3 receptors and drug craving in methamphetamine users Open

Angelica M. Morales, Milky Kohno, Chelsea L. Robertson, Andy C. Dean, M. Mandelkern , et al. · 2015

Denial in methamphetamine users: Associations with cognition and functional connectivity in brain Open

Andy C. Dean, Milky Kohno, Angelica M. Morales, Dara G. Ghahremani, Edythe D. London · 2015

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