Andy C. Tran
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View article: Structural Design and Immunogenicity of a Novel Self‐Adjuvanting Mucosal Vaccine Candidate for <scp>SARS</scp>‐<scp>CoV</scp>‐2 Expressed in Plants
Structural Design and Immunogenicity of a Novel Self‐Adjuvanting Mucosal Vaccine Candidate for <span>SARS</span>‐<span>CoV</span>‐2 Expressed in Plants Open
Mucosal vaccination for COVID‐19 to boost preexisting though insufficient systemic and local/mucosal immunity remains an attractive prospect but there are currently no licensed mucosal vaccines against this infection. Here, using a plant e…
View article: A composite subunit vaccine confers full protection against Buruli ulcer disease in the mouse footpad model of Mycobacterium ulcerans infection
A composite subunit vaccine confers full protection against Buruli ulcer disease in the mouse footpad model of Mycobacterium ulcerans infection Open
Buruli ulcer (BU) disease, a neglected necrotizing tropical skin infection caused by Mycobacterium ulcerans , is the third most common mycobacterial disease after tuberculosis and leprosy. Infections mostly occur in remote, rural areas of …
View article: A composite subunit vaccine confers full protection against Buruli ulcer disease in the mouse footpad model of<i>Mycobacterium ulcerans</i>infection
A composite subunit vaccine confers full protection against Buruli ulcer disease in the mouse footpad model of<i>Mycobacterium ulcerans</i>infection Open
Buruli ulcer (BU) disease, a neglected necrotizing tropical skin infection caused by Mycobacterium ulcerans , is the third most common mycobacterial disease after tuberculosis and leprosy. Infections mostly occur in remote, rural areas of …
View article: A modified mycobacterial growth inhibition assay for the functional assessment of vaccine-mediated immunity
A modified mycobacterial growth inhibition assay for the functional assessment of vaccine-mediated immunity Open
View article: Marked enhancement of the immunogenicity of plant‐expressed <scp>IgG‐Fc</scp> fusion proteins by inclusion of cholera toxin non‐toxic B subunit within the single polypeptide
Marked enhancement of the immunogenicity of plant‐expressed <span>IgG‐Fc</span> fusion proteins by inclusion of cholera toxin non‐toxic B subunit within the single polypeptide Open
Summary Immunoglobulin G (IgG)‐based fusion proteins have been widely exploited as a potential vaccine delivery platform but in the absence of exogenous adjuvants, the lack of robust immunity remains an obstacle. Here, we report on a key m…
View article: Specific Cationic Antimicrobial Peptides Enhance the Recovery of Low-Load Quiescent Mycobacterium tuberculosis in Routine Diagnostics
Specific Cationic Antimicrobial Peptides Enhance the Recovery of Low-Load Quiescent Mycobacterium tuberculosis in Routine Diagnostics Open
The culture confirmation of Mycobacterium tuberculosis (MTB) remains the gold standard for the diagnosis of Tuberculosis (TB) with culture conversion representing proof of cure. However, over 40% of TB samples fail to isolate MTB even thou…
View article: Inhibition of human cytomegalovirus replication by interferon alpha can involve multiple anti-viral factors
Inhibition of human cytomegalovirus replication by interferon alpha can involve multiple anti-viral factors Open
The shortcomings of current direct-acting anti-viral therapy against human cytomegalovirus (HCMV) has led to interest in host-directed therapy. Here we re-examine the use of interferon proteins to inhibit HCMV replication utilizing both hi…
View article: Mucosal and systemic immune responses after a single intranasal dose of nanoparticle and spore-based subunit vaccines in mice with pre-existing lung mycobacterial immunity
Mucosal and systemic immune responses after a single intranasal dose of nanoparticle and spore-based subunit vaccines in mice with pre-existing lung mycobacterial immunity Open
Tuberculosis (TB) is a major global health threat that claims more than one million lives annually. With a quarter of the global population harbouring latent TB, post-exposure vaccination aimed at high-risk populations that could develop a…
View article: Immunogenicity of PE18, PE31, and PPE26 proteins from Mycobacterium tuberculosis in humans and mice
Immunogenicity of PE18, PE31, and PPE26 proteins from Mycobacterium tuberculosis in humans and mice Open
Introduction The large family of PE and PPE proteins accounts for as much as 10% of the genome of Mycobacterium tuberculosis . In this study, we explored the immunogenicity of three proteins from this family, PE18, PE31, and PPE26, in huma…
View article: Spore-FP1 tuberculosis mucosal vaccine candidate is highly protective in guinea pigs but fails to improve on BCG-conferred protection in non-human primates
Spore-FP1 tuberculosis mucosal vaccine candidate is highly protective in guinea pigs but fails to improve on BCG-conferred protection in non-human primates Open
Tuberculosis remains a major health threat globally and a more effective vaccine than the current Bacillus Calmette Guerin (BCG) is required, either to replace or boost it. The Spore-FP1 mucosal vaccine candidate is based on the fusion pro…
View article: Serological analysis reveals differential antibody responses between TB patients and latently infected individuals from the TB endemic country of Mozambique
Serological analysis reveals differential antibody responses between TB patients and latently infected individuals from the TB endemic country of Mozambique Open
Serological antibody profiling of tuberculosis (TB) patients and household contacts with latent TB infection (LTBI) could identify risk indicators of disease progression, and potentially also serve as an easily accessible diagnostic tool t…
View article: Limited replication of human cytomegalovirus in a trophoblast cell line
Limited replication of human cytomegalovirus in a trophoblast cell line Open
Several viruses, including human cytomegalovirus (HCMV), are thought to replicate in the placenta. However, there is little understanding of the molecular mechanisms involved in HCMV replication in this tissue. We investigated replication …
View article: Palmitate‐mediated induction of neuropeptide Y expression occurs through intracellular metabolites and not direct exposure to proinflammatory cytokines
Palmitate‐mediated induction of neuropeptide Y expression occurs through intracellular metabolites and not direct exposure to proinflammatory cytokines Open
A contributing factor to the development of obesity is the consumption of a diet high in saturated fatty acids, such as palmitate. These fats induce hypothalamic neuroinflammation, which dysregulates neuronal function and induces orexigeni…
View article: Mucosal Therapy of Multi-Drug Resistant Tuberculosis With IgA and Interferon-γ
Mucosal Therapy of Multi-Drug Resistant Tuberculosis With IgA and Interferon-γ Open
New evidence has been emerging that antibodies can be protective in various experimental models of tuberculosis. Here, we report on protection against multidrug-resistant Mycobacterium tuberculosis (MDR-TB) infection using a combina…
View article: NAMPT and BMAL1 Are Independently Involved in the Palmitate-Mediated Induction of Neuroinflammation in Hypothalamic Neurons
NAMPT and BMAL1 Are Independently Involved in the Palmitate-Mediated Induction of Neuroinflammation in Hypothalamic Neurons Open
Obesity is a prominent metabolic disease that predisposes individuals to multiple comorbidities, including type 2 diabetes mellitus, cardiovascular diseases, and cancer. Elevated circulating levels of fatty acids contribute to the developm…
View article: Inactivated Lactobacillus plantarum Carrying a Surface-Displayed Ag85B-ESAT-6 Fusion Antigen as a Booster Vaccine Against Mycobacterium tuberculosis Infection
Inactivated Lactobacillus plantarum Carrying a Surface-Displayed Ag85B-ESAT-6 Fusion Antigen as a Booster Vaccine Against Mycobacterium tuberculosis Infection Open
Vaccination is considered the most effective strategy for controlling tuberculosis (TB). The existing vaccine, the Bacille Calmette-Guérin (BCG), although partially protective, has a number of limitations. Therefore, there is a need for de…
View article: Immunization With Mycobacterium tuberculosis Antigens Encapsulated in Phosphatidylserine Liposomes Improves Protection Afforded by BCG
Immunization With Mycobacterium tuberculosis Antigens Encapsulated in Phosphatidylserine Liposomes Improves Protection Afforded by BCG Open
Liposomes have been long considered as a vaccine delivery system but this technology remains to be fully utilized. Here, we describe a novel liposome-based subunit vaccine formulation for tuberculosis (TB) based on phosphatidylserine encap…
View article: SUN-482 Nitric Oxide Induces Spexin (Spx), Galanin Receptor 2 (GalR2), and Galanin Receptor 3 (GalR3) mRNA Independently of the cGMP/PKG Pathway and Enhances C/EBP-β Binding to the Spx 5’ Regulatory Region
SUN-482 Nitric Oxide Induces Spexin (Spx), Galanin Receptor 2 (GalR2), and Galanin Receptor 3 (GalR3) mRNA Independently of the cGMP/PKG Pathway and Enhances C/EBP-β Binding to the Spx 5’ Regulatory Region Open
Spexin (SPX) is a recently discovered peptide that binds to galanin receptors 2 (GalR2) and 3 (GalR3). Emerging evidence implicates SPX as a modulator of satiety and energy balance as circulating SPX levels are dysregulated in obesity. How…
View article: Emerging Themes for the Role of Antibodies in Tuberculosis
Emerging Themes for the Role of Antibodies in Tuberculosis Open
The best way to debunk a scientific dogma is to throw irrefutable evidence at it. This is especially true if the dogma in question has been nurtured over many decades, as is the case with the apparent redundancy of antibodies (Abs) against…
View article: Mucosal Delivery of Fusion Proteins with Bacillus subtilis Spores Enhances Protection against Tuberculosis by Bacillus Calmette-Guérin
Mucosal Delivery of Fusion Proteins with Bacillus subtilis Spores Enhances Protection against Tuberculosis by Bacillus Calmette-Guérin Open
Tuberculosis (TB) is the most deadly infectious disease in existence, and the only available vaccine, Bacillus Calmette-Guérin (BCG), is almost a century old and poorly protective. The immunological complexity of TB, coupled with ri…