Andy K.M. Lam
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View article: Inhibition mechanism of the chloride channel TMEM16A by the pore blocker 1PBC
Inhibition mechanism of the chloride channel TMEM16A by the pore blocker 1PBC Open
TMEM16A, a calcium-activated chloride channel involved in multiple cellular processes, is a proposed target for diseases such as hypertension, asthma, and cystic fibrosis. Despite these therapeutic promises, its pharmacology remains poorly…
View article: Gating the pore of the calcium-activated chloride channel TMEM16A
Gating the pore of the calcium-activated chloride channel TMEM16A Open
The binding of cytoplasmic Ca 2+ to the anion-selective channel TMEM16A triggers a conformational change around its binding site that is coupled to the release of a gate at the constricted neck of an hourglass-shaped pore. By combining mut…
View article: Calcium-dependent electrostatic control of anion access to the pore of the calcium-activated chloride channel TMEM16A
Calcium-dependent electrostatic control of anion access to the pore of the calcium-activated chloride channel TMEM16A Open
TMEM16A is a ligand-gated anion channel that is activated by intracellular Ca2+. This channel comprises two independent pores and closely apposed Ca2+ binding sites that are contained within each subunit of a homodimeric protein. Previousl…
View article: Author response: Calcium-dependent electrostatic control of anion access to the pore of the calcium-activated chloride channel TMEM16A
Author response: Calcium-dependent electrostatic control of anion access to the pore of the calcium-activated chloride channel TMEM16A Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract TMEM16A is a ligand-gated anion channel th…
View article: Structural basis for anion conduction in the calcium-activated chloride channel TMEM16A
Structural basis for anion conduction in the calcium-activated chloride channel TMEM16A Open
The calcium-activated chloride channel TMEM16A is a member of a conserved protein family that comprises ion channels and lipid scramblases. Although the structure of the scramblase nhTMEM16 has defined the architecture of the family, it wa…
View article: Author response: Structural basis for anion conduction in the calcium-activated chloride channel TMEM16A
Author response: Structural basis for anion conduction in the calcium-activated chloride channel TMEM16A Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Material and methods Appendix 1 Data availability References Decision letter Author response Article and author information Metrics Abstract The calcium-activat…
View article: Independent activation of ion conduction pores in the double-barreled calcium-activated chloride channel TMEM16A
Independent activation of ion conduction pores in the double-barreled calcium-activated chloride channel TMEM16A Open
The TMEM16 proteins constitute a family of membrane proteins with unusual functional breadth, including lipid scramblases and Cl− channels. Members of both these branches are activated by Ca2+, acting from the intracellular side, and proba…