Andy Law
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View article: The swine IsoLoop model of the gut host-microbiota interface enables intra-animal treatment comparisons to advance 3R principles
The swine IsoLoop model of the gut host-microbiota interface enables intra-animal treatment comparisons to advance 3R principles Open
Understanding gut-host microbiota interactions requires models that replicate human physiology while providing region-specific resolution, translational precision, and minimal animal use. To this end, we developed the IsoLoop model, a swin…
View article: Retrospective evaluation of perioperative clinical outcomes of diaphyseal femoral fractures repaired with the string-of-pearls locking plate system with adjunctive fixation
Retrospective evaluation of perioperative clinical outcomes of diaphyseal femoral fractures repaired with the string-of-pearls locking plate system with adjunctive fixation Open
OBJECTIVE To evaluate outcomes and complication rate of utilizing a string-of-pearls (SOP) plate augmented with adjunctive fixation in the repair of canine femur fractures. METHODS Records of canine patients with mid-diaphyseal femoral fra…
View article: Changes in hospital mortality in patients with cancer during the COVID-19 pandemic (ISARIC-CCP-UK): a prospective, multicentre cohort study
Changes in hospital mortality in patients with cancer during the COVID-19 pandemic (ISARIC-CCP-UK): a prospective, multicentre cohort study Open
National Institute for Health Research and the Medical Research Council.
View article: Sequencing and Analysis of Lumpy Skin Disease Virus Whole Genomes Reveals a New Viral Subgroup in West and Central Africa
Sequencing and Analysis of Lumpy Skin Disease Virus Whole Genomes Reveals a New Viral Subgroup in West and Central Africa Open
Lumpy skin disease virus (LSDV) is a member of the capripoxvirus (CPPV) genus of the Poxviridae family. LSDV is a rapidly emerging, high-consequence pathogen of cattle, recently spreading from Africa and the Middle East into Europe and Asi…
View article: Validation of Candidate Host Cell Entry Factors for Bovine Herpes Virus Type-1 Based on a Genome-Wide CRISPR Knockout Screen
Validation of Candidate Host Cell Entry Factors for Bovine Herpes Virus Type-1 Based on a Genome-Wide CRISPR Knockout Screen Open
To identify host factors that affect Bovine Herpes Virus Type 1 (BoHV-1) infection we previously applied a genome wide CRISPR knockout screen targeting all bovine protein coding genes. By doing so we compiled a list of both pro-viral and a…
View article: GARP and EARP are required for efficient BoHV-1 replication as identified by a genome wide CRISPR knockout screen
GARP and EARP are required for efficient BoHV-1 replication as identified by a genome wide CRISPR knockout screen Open
The advances in gene editing bring unprecedented opportunities in high throughput functional genomics to animal research. Here we describe a genome wide CRISPR knockout library, btCRISPRko.v1, targeting all protein coding genes in the catt…
View article: Health Care Utilization During the COVID-19 Pandemic Among Individuals Born Preterm
Health Care Utilization During the COVID-19 Pandemic Among Individuals Born Preterm Open
Importance: Limited data exist on pediatric health care utilization during the COVID-19 pandemic among children and young adults born preterm. Objective: To investigate differences in health care use related to COVID-19 concerns during the…
View article: Outcome of COVID-19 in hospitalised immunocompromised patients: An analysis of the WHO ISARIC CCP-UK prospective cohort study
Outcome of COVID-19 in hospitalised immunocompromised patients: An analysis of the WHO ISARIC CCP-UK prospective cohort study Open
Background Immunocompromised patients may be at higher risk of mortality if hospitalised with Coronavirus Disease 2019 (COVID-19) compared with immunocompetent patients. However, previous studies have been contradictory. We aimed to determ…
View article: Systematic comparison of ranking aggregation methods for gene lists in experimental results
Systematic comparison of ranking aggregation methods for gene lists in experimental results Open
Motivation A common experimental output in biomedical science is a list of genes implicated in a given biological process or disease. The gene lists resulting from a group of studies answering the same, or similar, questions can be combine…
View article: Outcome of COVID-19 in hospitalised immunocompromised patients: an analysis of the WHO ISARIC CCP-UK prospective cohort study
Outcome of COVID-19 in hospitalised immunocompromised patients: an analysis of the WHO ISARIC CCP-UK prospective cohort study Open
Background Immunocompromised patients may be at higher risk of mortality if hospitalised with COVID-19 compared with immunocompetent patients. However, previous studies have been contradictory. We aimed to determine whether immunocompromis…
View article: GWAS and meta-analysis identifies multiple new genetic mechanisms underlying severe Covid-19
GWAS and meta-analysis identifies multiple new genetic mechanisms underlying severe Covid-19 Open
Pulmonary inflammation drives critical illness in Covid-19, 1;2 creating a clinically homogeneous extreme phenotype, which we have previously shown to be highly efficient for discovery of genetic associations. 3;4 Despite the advanced stag…
View article: Systematic comparison of ranking aggregation methods for gene lists in experimental results
Systematic comparison of ranking aggregation methods for gene lists in experimental results Open
A common experimental output in biomedical science is a list of genes implicated in a given biological process or disease. The results of a group of studies answering the same, or similar, questions can be combined by meta-analysis to find…
View article: Whole genome sequencing identifies multiple loci for critical illness caused by COVID-19
Whole genome sequencing identifies multiple loci for critical illness caused by COVID-19 Open
Critical illness in COVID-19 is caused by inflammatory lung injury, mediated by the host immune system. We and others have shown that host genetic variation influences the development of illness requiring critical care 1 or hospitalisation…
View article: A novel strain of lumpy skin disease virus causes clinical disease in cattle in Hong Kong
A novel strain of lumpy skin disease virus causes clinical disease in cattle in Hong Kong Open
Lumpy skin disease virus (LSDV) is an emerging poxviral pathogen of cattle that is currently spreading throughout Asia. The disease situation is of high importance for farmers and policy makers in Asia. In October 2020, feral cattle in Hon…
View article: A novel strain of lumpy skin disease virus causes clinical disease in cattle in Hong Kong
A novel strain of lumpy skin disease virus causes clinical disease in cattle in Hong Kong Open
Summary Lumpy skin disease virus (LSDV) is an emerging poxviral pathogen of cattle that is currently spreading throughout Asia. The disease situation is of high importance for farmers and policy makers in Asia. In October 2020, feral cattl…
View article: Dynamic data-driven meta-analysis for prioritisation of host genes implicated in COVID-19
Dynamic data-driven meta-analysis for prioritisation of host genes implicated in COVID-19 Open
The increasing body of literature describing the role of host factors in COVID-19 pathogenesis demonstrates the need to combine diverse, multi-omic data to evaluate and substantiate the most robust evidence and inform development of therap…
View article: Dynamic data-driven meta-analysis for prioritisation of host genes implicated in COVID-19
Dynamic data-driven meta-analysis for prioritisation of host genes implicated in COVID-19 Open
The increasing body of literature describing the role of host factors in COVID-19 pathogenesis demonstrates the need to combine diverse, multi-omic data to evaluate and substantiate the most robust evidence and inform development of therap…
View article: Host cell factors important for BHV-1 cell entry revealed by genome-wide CRISPR knockout screen
Host cell factors important for BHV-1 cell entry revealed by genome-wide CRISPR knockout screen Open
In order to identify host factors that impact Bovine Herpes Virus Type 1 (BHV-1) infection we previously applied a genome wide CRISPR knockout screen with a library covering all bovine protein coding genes. We compiled a list of both pro-v…
View article: Genome-wide CRISPR knockout screen reveals membrane tethering complexes EARP and GARP important for Bovine Herpes Virus Type 1 replication
Genome-wide CRISPR knockout screen reveals membrane tethering complexes EARP and GARP important for Bovine Herpes Virus Type 1 replication Open
We produced a genome wide CRISPR knockout library, btCRISPRko.v1, targeting all protein coding genes in the cattle genome and used it to identify host genes important for Bovine Herpes Virus Type 1 (BHV-1) replication. By infecting library…
View article: Utilizing Optimized Tools to Investigate PTM Crosstalk: Identifying Potential PTM Crosstalk of Acetylated Mitochondrial Proteins
Utilizing Optimized Tools to Investigate PTM Crosstalk: Identifying Potential PTM Crosstalk of Acetylated Mitochondrial Proteins Open
Post-translational modification (PTM) crosstalk is recognized as a major cell-regulatory mechanism, and studies of several proteins have validated the premise that PTMs work in concert. Previous work by our group investigated the potential…
View article: Utilizing a Comprehensive Immunoprecipitation Enrichment System to Identify an Endogenous Post-translational Modification Profile for Target Proteins
Utilizing a Comprehensive Immunoprecipitation Enrichment System to Identify an Endogenous Post-translational Modification Profile for Target Proteins Open
It is now well-appreciated that post-translational modifications (PTMs) play an integral role in regulating a protein's structure and function, which may be essential for a given protein's role both physiologically and pathologically. Enri…
View article: A simple toolset to identify endogenous post-translational modifications for a target protein: a snapshot of the EGFR signaling pathway
A simple toolset to identify endogenous post-translational modifications for a target protein: a snapshot of the EGFR signaling pathway Open
Identification of a novel post-translational modification (PTM) for a target protein, defining its physiologic role and studying its potential cross-talk with other PTMs is a challenging process. A set of highly sensitive tools termed as S…
View article: Identifying Regulatory Posttranslational Modifications of PD-L1: A Focus on Monoubiquitinaton
Identifying Regulatory Posttranslational Modifications of PD-L1: A Focus on Monoubiquitinaton Open
A set of high-affinity, high-specificity posttranslational modification (PTM) enrichment tools was developed to generate an unbiased snapshot of four key PTM profiles (tyrosine phosphorylation, acetylation, ubiquitination, and SUMOylation …
View article: QTL analysis and genomic selection using RADseq derived markers in Sitka spruce: the potential utility of within family data
QTL analysis and genomic selection using RADseq derived markers in Sitka spruce: the potential utility of within family data Open
Sitka spruce (Picea sitchensis (Bong.) Carr) is the most common commercial plantation species in Britain and a breeding programme based on traditional lines has been in operation since the early 1960s. Rotation lengths of 40-years have led…
View article: Genetic loci inherited from hens lacking maternal behaviour both inhibit and paradoxically promote this behaviour
Genetic loci inherited from hens lacking maternal behaviour both inhibit and paradoxically promote this behaviour Open
The over-dominant locus on chromosome 5 coincides with the strongest selective sweep reported in chickens and together with the loci on chromosomes 1 and 8, they include genes of the thyrotrophic axis. This suggests that thyroid hormones m…