Andy M. Yip
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View article: Hepatic spheroids used as an in vitro model to study malaria relapse
Hepatic spheroids used as an in vitro model to study malaria relapse Open
Hypnozoites are the liver stage non-dividing form of the malaria parasite that are responsible for relapse and acts as a natural reservoir for human malaria Plasmodium vivax and P. ovale as well as a phylogenetically related simian malaria…
View article: The Plasmodium liver-specific protein 2 (LISP2) is an early marker of liver stage development
The Plasmodium liver-specific protein 2 (LISP2) is an early marker of liver stage development Open
Plasmodium vivax hypnozoites persist in the liver, cause malaria relapse and represent a major challenge to malaria elimination. Our previous transcriptomic study provided a novel molecular framework to enhance our understanding of the hyp…
View article: Discovery of Dengue Virus NS4B Inhibitors
Discovery of Dengue Virus NS4B Inhibitors Open
The four serotypes of dengue virus (DENV-1 to -4) represent the most prevalent mosquito-borne viral pathogens in humans. No clinically approved vaccine or antiviral is currently available for DENV. Here we report a spiropyrazolopyridone co…
View article: Lead Optimization of Spiropyrazolopyridones: A New and Potent Class of Dengue Virus Inhibitors
Lead Optimization of Spiropyrazolopyridones: A New and Potent Class of Dengue Virus Inhibitors Open
Spiropyrazolopyridone 1 was identified, as a novel dengue virus (DENV) inhibitor, from a DENV serotype 2 (DENV-2) high-throughput phenotypic screen. As a general trend within this chemical class, chiral resolution of the racemate revealed …