Andy Peng Xiang
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View article: A single-cell atlas of the testicular interstitium defines Leydig progenitor networks sustaining Leydig cell homeostasis across the lifespan
A single-cell atlas of the testicular interstitium defines Leydig progenitor networks sustaining Leydig cell homeostasis across the lifespan Open
Declining rates of male fertility pose a significant clinical challenge, while the mechanisms underlying testicular interstitial function remain incompletely understood. Here, we conducted a comprehensive analysis of the single-cell transc…
View article: Gremlin1-MSCs seeded on small-diameter artificial blood vessels facilitate attenuation of post-transplantation intimal hyperplasia
Gremlin1-MSCs seeded on small-diameter artificial blood vessels facilitate attenuation of post-transplantation intimal hyperplasia Open
Artificial blood vessels are commonly used to treat vascular damage and diseases. While large-diameter artificial blood vessels have been widely used in clinical practice, small-diameter artificial blood vessels (<6 mm) face significant ch…
View article: Transplantation of hiPSC-derived pericytes rescues Alzheimer’s disease phenotypes in APOE4/4 mice through IGF2-rich apoptotic vesicles
Transplantation of hiPSC-derived pericytes rescues Alzheimer’s disease phenotypes in APOE4/4 mice through IGF2-rich apoptotic vesicles Open
Background Effective therapies for Alzheimer’s disease (AD) remain to be developed. APOE4 is the strongest genetic risk factor for late-onset AD. Pericyte degeneration and blood–brain barrier (BBB) disruption are thought to be early biomar…
View article: Macrophage metabolism in inflammatory heart disease: new insights and therapeutic implications
Macrophage metabolism in inflammatory heart disease: new insights and therapeutic implications Open
Macrophages are essential immune cells involved in pathogen clearance, initiation and resolution of inflammation, and tissue repair across multiple organ systems. They exhibit remarkable phenotypic diversity, encompassing classical M1 and …
View article: Mitochondria‐Localized Nestin Protects Mesenchymal Stem Cells from Senescence by Maintaining Cristae Structure and Function
Mitochondria‐Localized Nestin Protects Mesenchymal Stem Cells from Senescence by Maintaining Cristae Structure and Function Open
Nestin, a well‐characterized intermediate filament protein expressed in stem cells, is increasingly recognized for its non‐canonical roles in diverse subcellular compartments. Here, a novel mitochondrial localization of Nestin in human mes…
View article: MYBPC3 (c.194CT) mutation-mediated RyR2 dysfunction contributes to pathogenic phenotypes of DCM revealed by hiPSC modeling
MYBPC3 (c.194CT) mutation-mediated RyR2 dysfunction contributes to pathogenic phenotypes of DCM revealed by hiPSC modeling Open
Dilated cardiomyopathy (DCM) is a leading cause of heart failure and the primary indication for heart transplantation. The intricate and poorly elucidated pathogenesis of genetic DCM, coupled with the paucity of effective therapeutic optio…
View article: High matrix stiffness triggers testosterone decline in aging males by disrupting stem Leydig cell pool homeostasis
High matrix stiffness triggers testosterone decline in aging males by disrupting stem Leydig cell pool homeostasis Open
Aging is closely related to the decline of male reproductive endocrine function, which is manifested as insufficient testosterone production. It is well known that stem cell pool stability is crucial for maintaining tissue function. Howeve…
View article: Mesenchymal Stromal Cells Play an Analgesic Role Through a <i>Npy2r</i> Sensory Neuron‐Mediated Lung‐to‐Brain Axis
Mesenchymal Stromal Cells Play an Analgesic Role Through a <i>Npy2r</i> Sensory Neuron‐Mediated Lung‐to‐Brain Axis Open
Mesenchymal stromal cells (MSC) have emerged as a promising therapeutic option for neuropathic pain (NP), but the mechanisms remain elusive. Using murine pain models, it is demonstrated that MSC effectively alleviates pain, with efficacy c…
View article: Human iPSC-based breast cancer model identifies S100P-dependent cancer stemness induced by <i>BRCA1</i> mutation
Human iPSC-based breast cancer model identifies S100P-dependent cancer stemness induced by <i>BRCA1</i> mutation Open
Breast cancer is the most common malignancy in females and remains the leading cause of cancer-related deaths for women worldwide. The cellular and molecular basis of breast tumorigenesis is not completely understood partly due to the lack…
View article: Reduced morbidity and mortality of cGVHD in patients who received treatment with mesenchymal stromal cells for steroid-resistant aGVHD: long-term follow-up of a randomized phase 3 trial
Reduced morbidity and mortality of cGVHD in patients who received treatment with mesenchymal stromal cells for steroid-resistant aGVHD: long-term follow-up of a randomized phase 3 trial Open
Background Our open-label, multicenter, randomized, phase 3 trial showed that the incidence and severity of chronic graft-versus-host disease (cGVHD) reduced in steroid-resistant acute graft-versus-host disease (aGVHD) patients who underwe…
View article: The mediating effect of alexithymia in the symptom burden and depression in patients with maintenance hemodialysis
The mediating effect of alexithymia in the symptom burden and depression in patients with maintenance hemodialysis Open
Aim This study aimed to investigate the prevalence of alexithymia among patients receiving maintenance haemodialysis (MHD) and whether it plays a role in the relationship between symptom burden and depression in this population. Background…
View article: Lactate accumulation drives hepatocellular carcinoma metastasis through facilitating tumor-derived exosome biogenesis by Rab7A lactylation
Lactate accumulation drives hepatocellular carcinoma metastasis through facilitating tumor-derived exosome biogenesis by Rab7A lactylation Open
Previous studies have demonstrated that lactate accumulation, a common hallmark for metabolic deprivation in solid tumors, could actively drive tumor invasion and metastasis. However, whether lactate influences the biogenesis of tumor-deri…
View article: Functional inhibition of core spliceosomal machinery activates intronic premature cleavage and polyadenylation of pre-mRNAs
Functional inhibition of core spliceosomal machinery activates intronic premature cleavage and polyadenylation of pre-mRNAs Open
The catalytic role of U6 snRNP in pre-mRNA splicing has been well established. In this study, we utilize an antisense morpholino oligonucleotide (AMO) specifically targeting catalytic sites of U6 snRNA to achieve functional knockdown of U6…
View article: <i>MYBPC3</i>(c.194C>T) mutation-mediated RyR2 dysfunction contributes to pathogenic phenotypes of dilated cardiomyopathy revealed by hiPSC modeling
<i>MYBPC3</i>(c.194C>T) mutation-mediated RyR2 dysfunction contributes to pathogenic phenotypes of dilated cardiomyopathy revealed by hiPSC modeling Open
Dilated cardiomyopathy (DCM) is a leading cause of heart failure and the primary indication for heart transplantation. The intricate and poorly elucidated pathogenesis of genetic DCM, coupled with the paucity of effective therapeutic optio…
View article: Gastric Cancer Actively Remodels Mechanical Microenvironment to Promote Chemotherapy Resistance via MSCs‐Mediated Mitochondrial Transfer (Adv. Sci. 47/2024)
Gastric Cancer Actively Remodels Mechanical Microenvironment to Promote Chemotherapy Resistance via MSCs‐Mediated Mitochondrial Transfer (Adv. Sci. 47/2024) Open
Gastric Cancer The cover image shows Earth representing a gastric cancer (GC) cell, surrounded by multiple satellites symbolizing mesenchymal stromal cells (MSCs) in the tumor microenvironment. Numerous meteors, representing the chemothera…
View article: Ex vivo-generated human CD1c+ regulatory B cells by a chemically defined system suppress immune responses and alleviate graft-versus-host disease
Ex vivo-generated human CD1c+ regulatory B cells by a chemically defined system suppress immune responses and alleviate graft-versus-host disease Open
IL-10+ regulatory B cells (Bregs) show great promise in treating graft-versus-host disease (GVHD), a life-threatening complication of post-hematopoietic stem cell transplantation. However, obtaining high-quality human IL-10+ Bregs in vitro…
View article: Gastric Cancer Actively Remodels Mechanical Microenvironment to Promote Chemotherapy Resistance via MSCs‐Mediated Mitochondrial Transfer
Gastric Cancer Actively Remodels Mechanical Microenvironment to Promote Chemotherapy Resistance via MSCs‐Mediated Mitochondrial Transfer Open
Chemotherapy resistance is the main reason of treatment failure in gastric cancer (GC). However, the mechanism of oxaliplatin (OXA) resistance remains unclear. Here, we demonstrate that extracellular mechanical signaling plays crucial role…
View article: Objectively Evaluating the Reliability of Cell Type Annotation Using LLM-Based Strategies
Objectively Evaluating the Reliability of Cell Type Annotation Using LLM-Based Strategies Open
Reliability in cell type annotation is challenging in single-cell RNA-sequencing data analysis because both expert-driven and automated methods can be biased or constrained by their training data, especially for novel or rare cell types. A…
View article: Single-cell RNA sequencing reveals transcriptomic landscape and potential targets for human testicular ageing
Single-cell RNA sequencing reveals transcriptomic landscape and potential targets for human testicular ageing Open
STUDY QUESTION What is the molecular landscape underlying the functional decline of human testicular ageing? SUMMARY ANSWER The present study provides a comprehensive single-cell transcriptomic atlas of testes from young and old humans and…
View article: Impaired ketogenesis in Leydig Cells drives testicular aging
Impaired ketogenesis in Leydig Cells drives testicular aging Open
Testicular aging commonly leads to testosterone deficiency and impaired spermatogenesis, yet the underlying mechanisms remain elusive. Here, a comprehensive analysis of senescence landscapes in mice testes during aging revealed that the Le…