Andy Shao
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View article: Ocular Phenotyping of Knockout Mice Identifies Genes Associated With Late Adult Retinal Phenotypes
Ocular Phenotyping of Knockout Mice Identifies Genes Associated With Late Adult Retinal Phenotypes Open
We identified 12 mouse genes with significant late-adult abnormal retinal pathology, eight of which have not been previously implicated in either mouse or human retinal physiology or pathology. These serve as novel retinal disease gene can…
View article: 307 Revealing Candidate Inherited Retinal Disease Candidates via Genome-wide Screening of Knockout Mice
307 Revealing Candidate Inherited Retinal Disease Candidates via Genome-wide Screening of Knockout Mice Open
OBJECTIVES/GOALS: The goal of this study is to reveal strong candidate genes for inherited retinal diseases (IRDs) in humans to better understand the mechanisms behind IRD development and reveal potential therapeutic targets. We hope these…
View article: <i>Arap1</i> loss causes retinal pigment epithelium phagocytic dysfunction and subsequent photoreceptor death
<i>Arap1</i> loss causes retinal pigment epithelium phagocytic dysfunction and subsequent photoreceptor death Open
Retinitis pigmentosa (RP), a retinal degenerative disease, is the leading cause of heritable blindness. Previously, we described that Arap1−/− mice develop a similar pattern of photoreceptor degeneration. Arap1 is an Arf-directed GTPase-ac…