Andy Y. Shih
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View article: Endothelial-leukocyte interaction in CAR T cell neurotoxicity
Endothelial-leukocyte interaction in CAR T cell neurotoxicity Open
CD19-directed CAR T cells treat cancer, but also cause immune effector cell associated neurotoxicity syndrome (ICANS). Despite strong epidemiologic links between cytokine release syndrome and ICANS, it is uncertain how elevated systemic cy…
View article: Capillary regression leads to sustained local hypoperfusion by inducing constriction of upstream transitional vessels
Capillary regression leads to sustained local hypoperfusion by inducing constriction of upstream transitional vessels Open
In the brain, a microvascular sensory web coordinates oxygen delivery to regions of neuronal activity. This involves a dense network of capillaries that send conductive signals upstream to feeding arterioles to promote vasodilation and blo…
View article: Impaired drainage through capillary-venous networks contributes to age-related white matter loss
Impaired drainage through capillary-venous networks contributes to age-related white matter loss Open
The gradual loss of cerebral white matter contributes to cognitive decline during aging. However, microvascular networks that support the metabolic demands of white matter remain poorly defined. We used in vivo deep multi-photon imaging to…
View article: Impaired capillary-venous drainage contributes to gliosis and demyelination in white matter during aging
Impaired capillary-venous drainage contributes to gliosis and demyelination in white matter during aging Open
The progressive loss of cerebral white matter during aging contributes to cognitive decline, but whether reduced blood flow is a cause or consequence remains debated. Using deep multi-photon imaging in mice, we examined microvascular netwo…
View article: A translational approach towards understanding brain waste clearance in cerebral amyloid angiopathy
A translational approach towards understanding brain waste clearance in cerebral amyloid angiopathy Open
International audience
View article: The elusive brain perivascular fibroblast: a potential role in vascular stability and homeostasis
The elusive brain perivascular fibroblast: a potential role in vascular stability and homeostasis Open
In the brain, perivascular fibroblasts (PVFs) reside within the perivascular spaces (PVSs) of arterioles and large venules, however their physiological and pathophysiological roles remain largely unknown. PVFs express numerous extracellula…
View article: Capillary regression leads to sustained local hypoperfusion by inducing constriction of upstream transitional vessels
Capillary regression leads to sustained local hypoperfusion by inducing constriction of upstream transitional vessels Open
In the brain, a microvascular sensory web coordinates oxygen delivery to regions of neuronal activity. This involves a dense network of capillaries that send conductive signals upstream to feeding arterioles to promote vasodilation and blo…
View article: Diverse Conventions for Human-AI Collaboration
Diverse Conventions for Human-AI Collaboration Open
Conventions are crucial for strong performance in cooperative multi-agent games, because they allow players to coordinate on a shared strategy without explicit communication. Unfortunately, standard multi-agent reinforcement learning techn…
View article: Meningeal origins and dynamics of perivascular fibroblast development on the mouse cerebral vasculature
Meningeal origins and dynamics of perivascular fibroblast development on the mouse cerebral vasculature Open
Perivascular fibroblasts (PVFs) are a fibroblast-like cell type that reside on large-diameter blood vessels in the adult meninges and central nervous system (CNS). PVFs contribute to fibrosis following injury but their homeostatic function…
View article: Purinergic signaling mediates neuroglial interactions to modulate sighs
Purinergic signaling mediates neuroglial interactions to modulate sighs Open
Sighs prevent the collapse of alveoli in the lungs, initiate arousal under hypoxic conditions, and are an expression of sadness and relief. Sighs are periodically superimposed on normal breaths, known as eupnea. Implicated in the generatio…
View article: A neuropathologic feature of brain aging: multi-lumen vascular profiles
A neuropathologic feature of brain aging: multi-lumen vascular profiles Open
Cerebrovascular pathologies other than frank infarctions are commonly seen in aged brains. Here, we focus on multi-lumen vascular profiles (MVPs), which are characterized by multiple vessel lumens enclosed in a single vascular channel. Lit…
View article: Parallel Sampling of Diffusion Models
Parallel Sampling of Diffusion Models Open
Diffusion models are powerful generative models but suffer from slow sampling, often taking 1000 sequential denoising steps for one sample. As a result, considerable efforts have been directed toward reducing the number of denoising steps,…
View article: Does Perinatal Intermittent Hypoxia Affect Cerebrovascular Network Development?
Does Perinatal Intermittent Hypoxia Affect Cerebrovascular Network Development? Open
Perinatal hypoxia is an inadequate delivery of oxygen to the fetus in the period immediately before, during, or after the birth process. The most frequent form of hypoxia occurring in human development is chronic intermittent hypoxia (CIH)…
View article: Endothelial structure contributes to heterogeneity in brain capillary diameter
Endothelial structure contributes to heterogeneity in brain capillary diameter Open
The high metabolic demand of brain tissue is supported by a constant supply of blood through dense microvascular networks. Capillaries are the smallest class of vessels and vary in diameter between ∼2 to 5 μm in the brain. This diameter ra…
View article: Deep Imaging to Dissect Microvascular Contributions to White Matter Degeneration in Rodent Models of Dementia
Deep Imaging to Dissect Microvascular Contributions to White Matter Degeneration in Rodent Models of Dementia Open
The increasing socio-economic burden of Alzheimer disease (AD) and AD-related dementias has created a pressing need to define targets for therapeutic intervention. Deficits in cerebral blood flow and neurovascular function have emerged as …
View article: Editorial: Pathway of care and gaps in services for children and adults with autism spectrum disorder
Editorial: Pathway of care and gaps in services for children and adults with autism spectrum disorder Open
EDITORIAL article Front. Psychiatry, 13 April 2023Sec. Autism Volume 14 - 2023 | https://doi.org/10.3389/fpsyt.2023.1193166
View article: The Neurovasculome: Key Roles in Brain Health and Cognitive Impairment: A Scientific Statement From the American Heart Association/American Stroke Association
The Neurovasculome: Key Roles in Brain Health and Cognitive Impairment: A Scientific Statement From the American Heart Association/American Stroke Association Open
Background: Preservation of brain health has emerged as a leading public health priority for the aging world population. Advances in neurovascular biology have revealed an intricate relationship among brain cells, meninges, and the hematic…
View article: Meningeal origins and dynamics of perivascular fibroblast development on the mouse cerebral vasculature
Meningeal origins and dynamics of perivascular fibroblast development on the mouse cerebral vasculature Open
Perivascular fibroblasts (PVFs) are a fibroblast-like cell type that reside on large-diameter blood vessels in the adult meninges and central nervous system (CNS). PVFs drive fibrosis following injury but their homeostatic functions are no…
View article: Long Horizon Temperature Scaling
Long Horizon Temperature Scaling Open
Temperature scaling is a popular technique for tuning the sharpness of a model distribution. It is used extensively for sampling likely generations and calibrating model uncertainty, and even features as a controllable parameter to many la…
View article: Fully Printed pH Sensor based on Polyaniline/Graphite Nanocomposites
Fully Printed pH Sensor based on Polyaniline/Graphite Nanocomposites Open
Recently, there is an exceptional growth in research related to the development of flexible sensors for health analysis. pH measurements can be done non-invasively and continuously, making it an excellent parameter for monitoring different…
View article: Endothelial structure contributes to heterogeneity in brain capillary diameter
Endothelial structure contributes to heterogeneity in brain capillary diameter Open
The high metabolic demand of brain tissue is supported by a constant supply of blood flow through dense microvascular networks. Capillaries are the smallest class of vessels in the brain and their lumens vary in diameter between ~2 and 5 μ…
View article: INF2-mediated actin filament reorganization confers intrinsic resilience to neuronal ischemic injury
INF2-mediated actin filament reorganization confers intrinsic resilience to neuronal ischemic injury Open
During early ischemic brain injury, glutamate receptor hyperactivation mediates neuronal death via osmotic cell swelling. Here we show that ischemia and excess NMDA receptor activation cause actin to rapidly and extensively reorganize with…
View article: Special Section Guest Editorial: Imaging Neuroimmune, Neuroglial, and Neurovascular Interfaces
Special Section Guest Editorial: Imaging Neuroimmune, Neuroglial, and Neurovascular Interfaces Open
The guest editorial provides an introduction to Parts 1 and 2 of the Neurophotonics Special Section on Imaging Neuroimmune, Neuroglial, and Neurovascular Interfaces.
View article: 3D optogenetic control of arteriole diameter in vivo
3D optogenetic control of arteriole diameter in vivo Open
Modulation of brain arteriole diameter is critical for maintaining cerebral blood pressure and controlling regional hyperemia during neural activity. However, studies of hemodynamic function in health and disease have lacked a method to co…