Andrew W. Grande
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View article: Coordinate-Dependent Neuroinflammation and Metabolic Disruption Following Experimental Traumatic Brain Injury
Coordinate-Dependent Neuroinflammation and Metabolic Disruption Following Experimental Traumatic Brain Injury Open
Traumatic brain injury (TBI) is a leading cause of long-term neurological dysfunction, with secondary neuroinflammation playing a pivotal role in disease progression. Microglia, the brain’s resident immune cells, respond to injury in a spe…
View article: Prospective Trial of Cerebrospinal Fluid Filtration After Aneurysmal Subarachnoid Hemorrhage via Lumbar Catheter Extension (PILLAR-XT)
Prospective Trial of Cerebrospinal Fluid Filtration After Aneurysmal Subarachnoid Hemorrhage via Lumbar Catheter Extension (PILLAR-XT) Open
Background There is a growing consensus that blood in the cerebrospinal fluid (CSF) is deleterious to outcomes in patients with aneurysmal subarachnoid hemorrhage. The extracorporeal filtration of subarachnoid hemorrhage via spinal cathete…
View article: Astrocyte to neuron reprogramming with NeuroD1 for repair in canine stroke
Astrocyte to neuron reprogramming with NeuroD1 for repair in canine stroke Open
Stroke affects hundreds of thousands of people each year and leads to neuronal damage and often long term disabilities. This study served as an exploratory study investigating astrocyte to neuron reprogramming as a potential treatment for …
View article: The use of indocyanine green and technetium-99 for dual-tracer sentinel lymph node biopsy in breast cancer
The use of indocyanine green and technetium-99 for dual-tracer sentinel lymph node biopsy in breast cancer Open
Purpose The aim of this study was to determine if indocyanine green (ICG) is a suitable replacement for blue dye for dual-tracer sentinel lymph node biopsy (SLNB). Methods A single-center retrospective review of female breast cancer patien…
View article: Functional Neural Connectivity of the Mouse Brain using Photoacoustic Ultrasound Imaging
Functional Neural Connectivity of the Mouse Brain using Photoacoustic Ultrasound Imaging Open
Brain connectomes are insightful models that describe the connectivity of different regions throughout the brain. These connectomes are traditionally generated through temporal correlation of blood oxygen level dependent (BOLD) signals det…
View article: Exosomes derived from highly scalable and regenerative human progenitor cells promote functional improvement in a rat model of ischemic stroke
Exosomes derived from highly scalable and regenerative human progenitor cells promote functional improvement in a rat model of ischemic stroke Open
Globally, there are 15 million stroke patients each year who have significant neurological deficits. Today, there are no treatments that directly address these deficits. With demographics shifting to an older population, the problem is wor…
View article: Research Guideline Recommendations for Research on Stem Cells, Human Embryos, and Gene Editing
Research Guideline Recommendations for Research on Stem Cells, Human Embryos, and Gene Editing Open
Recent advances in biomedical technologies have extended the boundaries of previously established regulatory guidelines pertaining to stem cell research. These guidelines constrained the study of human pluripotent stem cells (hPSCs) and th…
View article: Direct Percutaneous Embolization of Head, Neck and Spine Tumors: A Single Center Experience
Direct Percutaneous Embolization of Head, Neck and Spine Tumors: A Single Center Experience Open
Introduction Transarterial embolization is a well-established adjunct in the management of hypervascular head, neck, and spine tumors. Few case-series have described the role of direct percutaneous embolization (DPE). Method We report our …
View article: Emerging Roles of Exosomes in Stroke Therapy
Emerging Roles of Exosomes in Stroke Therapy Open
Stroke is the number one cause of morbidity in the United States and number two cause of death worldwide. There is a critical unmet medical need for more effective treatments of ischemic stroke, and this need is increasing with the shift i…
View article: Emerging Roles of Exosomes in Stroke Therapy
Emerging Roles of Exosomes in Stroke Therapy Open
Stroke is the number one cause of morbidity in the United States and number two cause of death worldwide. There is a critical unmet medical need for more effective treatments of ischemic stroke, and this need is increasing with the shift i…
View article: Use of reverse angle guide catheter with trans-radial approach in patients undergoing middle meningeal artery embolization
Use of reverse angle guide catheter with trans-radial approach in patients undergoing middle meningeal artery embolization Open
Background Trans-radial access (TRA) for MMA embolization has grown due to lower access site complications and greater patient satisfaction. Here, we describe the feasibility of utilizing a 6F Envoy Simmons 2 (6F-SIM2) as a guide catheter …
View article: Cell Reprogramming for Regeneration and Repair of the Nervous System
Cell Reprogramming for Regeneration and Repair of the Nervous System Open
A persistent barrier to the cure and treatment of neurological diseases is the limited ability of the central and peripheral nervous systems to undergo neuroregeneration and repair. Recent efforts have turned to regeneration of various cel…
View article: Half‐Dose (45 mg Twice Daily) Ticagrelor Versus Clopidogrel in Neuroendovascular Dual Antiplatelet Therapy: A Single‐Center Cohort Study
Half‐Dose (45 mg Twice Daily) Ticagrelor Versus Clopidogrel in Neuroendovascular Dual Antiplatelet Therapy: A Single‐Center Cohort Study Open
Background Cardiovascular literature has found aspirin‐based dual antiplatelet therapy using half‐dose ticagrelor (45 mg BID [T45]) to be superior to standard‐dose clopidogrel (75 mg once daily) in achieving lower P2Y12 reaction units with…
View article: Flow residence time in intracranial aneurysms evaluated by in vitro 4D flow MRI
Flow residence time in intracranial aneurysms evaluated by in vitro 4D flow MRI Open
The process of an intracranial aneurysm development, growth, and rupture is multifaceted and complex. In addition, clinical observations have identified the potential of thrombus formation within such aneurysms. While the underlying mechan…
View article: BOBBY balloon guide catheter thrombectomy in large-vessel occlusion stroke: Initial experience
BOBBY balloon guide catheter thrombectomy in large-vessel occlusion stroke: Initial experience Open
Background and Purpose Nonrandomized studies have found Balloon Guide Catheter (BGC) use to improve technical and functional outcomes in patients undergoing mechanical thrombectomy (MT). Materials and Methods We performed a retrospective a…
View article: 300 Improving the diagnosis and classification of facial pain conditions with MRI-based features
300 Improving the diagnosis and classification of facial pain conditions with MRI-based features Open
OBJECTIVES/GOALS: Trigeminal Neuralgia (TN) is a debilitating neuropathic condition characterized by electric-shock-like pain attacks. TN is considered a clinical diagnosis, and few proposed objective markers exist. This work studies the a…
View article: Personalizing Dual-Target Cortical Stimulation with Bayesian Parameter Optimization Successfully Treats Central Post-Stroke Pain: A Case Report
Personalizing Dual-Target Cortical Stimulation with Bayesian Parameter Optimization Successfully Treats Central Post-Stroke Pain: A Case Report Open
Central pain disorders, such as central post-stroke pain, remain clinically challenging to treat, despite many decades of pharmacological advances and the evolution of neuromodulation. For treatment refractory cases, previous studies have …
View article: Microglia and Macrophages in Neuroprotection, Neurogenesis, and Emerging Therapies for Stroke
Microglia and Macrophages in Neuroprotection, Neurogenesis, and Emerging Therapies for Stroke Open
Stroke remains the number one cause of morbidity in the United States. Within weeks to months after an ischemic event, there is a resolution of inflammation and evidence of neurogenesis; however, years following a stroke, there is evidence…
View article: Effect of Hispanic Status in Mechanical Thrombectomy Outcomes After Ischemic Stroke: Insights From STAR
Effect of Hispanic Status in Mechanical Thrombectomy Outcomes After Ischemic Stroke: Insights From STAR Open
Background and Purpose: Epidemiological studies have shown racial and ethnic minorities to have higher stroke risk and worse outcomes than non-Hispanic Whites. In this cohort study, we analyzed the STAR (Stroke Thrombectomy and Aneurysm Re…
View article: Three-dimensional vortex characterization in small intracranial aneurysms based on four dimensional flow magnetic resonance imaging at 7 Tesla
Three-dimensional vortex characterization in small intracranial aneurysms based on four dimensional flow magnetic resonance imaging at 7 Tesla Open
Effective vectors and approaches are proposed to identify the three-dimensional (3D) vortex motion in small intracranial aneurysms (≤7 mm) based on four dimensional flow magnetic resonance imaging at 7 T. Six subjects with small intracrani…
View article: P-008 Effect of hispanic status in mechanical thrombectomy outcomes after large vessel occlusion ischemic stroke: insights from STAR
P-008 Effect of hispanic status in mechanical thrombectomy outcomes after large vessel occlusion ischemic stroke: insights from STAR Open
Background and Purpose Epidemiologic studies have shown racial and ethnic minorities to have higher stroke risk and worse outcomes than non-Hispanic Whites. In this cohort study, we analyzed the STAR database, a multi-institutional databas…
View article: Scepter-Mini Balloon Assisted Coil Embolization of an Intracranial Arterial Aneurysm in a Child with PHACE Syndrome via a Persistent Trigeminal Artery
Scepter-Mini Balloon Assisted Coil Embolization of an Intracranial Arterial Aneurysm in a Child with PHACE Syndrome via a Persistent Trigeminal Artery Open
Cerebral vascular malformations constitute one of the key abnormalities in children with PHACE syndrome, which is characterized by Plaque like cutaneous hemangiomas, Posterior fossa abnormalities, arterial Cerebrovascular and Eye abnormali…
View article: Readmission Trends Related to Unruptured Intracranial Aneurysm Treatment
Readmission Trends Related to Unruptured Intracranial Aneurysm Treatment Open
Background and Purpose: Aneurysmal subarachnoid hemorrhage (SAH) is associated with high mortality. Prophylactic treatment of the unruptured intracranial aneurysm (UIA) is considered in a select group of patients thought to be at high for …
View article: Intracranial Stenting: Angioplasty Basic Technique, Indications, and Sizing: 2-Dimensional Operative Video
Intracranial Stenting: Angioplasty Basic Technique, Indications, and Sizing: 2-Dimensional Operative Video Open
Intracranial atherosclerotic disease (ICAD) is a common cause of stroke. Antiplatelet therapy is the mainstay for symptomatic ICAD treatment. Endovascular management with submaximal angioplasty and/or intracranial stenting is reserved for …
View article: Is a picture-perfect thrombectomy necessary in acute ischemic stroke?
Is a picture-perfect thrombectomy necessary in acute ischemic stroke? Open
Background The benefit of complete reperfusion (modified Thrombolysis in Cerebral Infarction (mTICI) 3) over near-complete reperfusion (≥90%, mTICI 2c) remains unclear. The goal of this study is to compare clinical outcomes between mechani…
View article: Transarterial Embolization of a Transverse Sinus Dural Arteriovenous Fistula: 2-Dimensional Operative Video
Transarterial Embolization of a Transverse Sinus Dural Arteriovenous Fistula: 2-Dimensional Operative Video Open
A 40-yr-old male with no significant past medical history presented with sudden onset right-sided retro-orbital headache associated with vision loss after a session of strenuous exercise. Initial assessment with noncontrast head computed t…
View article: Distal Access to Wide-Necked Aneurysms—‘Around the World’ Technique: 2-Dimensional Operative Video
Distal Access to Wide-Necked Aneurysms—‘Around the World’ Technique: 2-Dimensional Operative Video Open
Wide-necked aneurysms often pose challenges for distal access to the distal vasculature. This 64-yr-old woman without neurological deficits presented with atypical headaches of gradual onset. MRI revealed a large, symptomatic, unruptured c…
View article: Stent-Assisted Coiling of a Sidewall Aneurysm of the Distal Middle Cerebral Artery: 2-Dimensional Operative Video
Stent-Assisted Coiling of a Sidewall Aneurysm of the Distal Middle Cerebral Artery: 2-Dimensional Operative Video Open
Sidewall aneurysm treatment often requires complex management strategies. These can include advanced clipping techniques or stent-assisted coiling techniques. Endovascular coiling alone has been associated with high recurrence rates and is…
View article: Pipeline embolization device for treatment of atypical facial pain caused by a cavernous sinus aneurysm
Pipeline embolization device for treatment of atypical facial pain caused by a cavernous sinus aneurysm Open
We present the case of a 53-year-old woman who presented with left-sided atypical facial pain in the V1-V2 distribution of the trigeminal nerve. Further imaging workup revealed a left-sided cavernous aneurysm compressing the V1 and V2 root…