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View article: Nedd4-2-dependent regulation of astrocytic Kir4.1 and Connexin43 controls neuronal network activity
Nedd4-2-dependent regulation of astrocytic Kir4.1 and Connexin43 controls neuronal network activity Open
Nedd4-2 is an E3 ubiquitin ligase in which missense mutation is related to familial epilepsy, indicating its critical role in regulating neuronal network activity. However, Nedd4-2 substrates involved in neuronal network function have yet …
View article: Linking emotional valence and anxiety in a mouse insula-amygdala circuit
Linking emotional valence and anxiety in a mouse insula-amygdala circuit Open
Responses of the insular cortex (IC) and amygdala to stimuli of positive and negative valence are altered in patients with anxiety disorders. However, neural coding of both anxiety and valence by IC neurons remains unknown. Using fiber pho…
View article: Regulation of excitatory presynaptic activity by Ambra1 protein determines neuronal networks in sex-dimorphic manner
Regulation of excitatory presynaptic activity by Ambra1 protein determines neuronal networks in sex-dimorphic manner Open
Heterozygous mutation of Ambra1 , known as a positive autophagy regulator, produces autismlike behavior in mice and autistic phenotypes in humans in a female-specific manner. However, the substantial roles of the Ambra1 mutation in neurons…
View article: Linking emotional valence and anxiety in a mouse insula-amygdala circuit
Linking emotional valence and anxiety in a mouse insula-amygdala circuit Open
The response of the insular cortex (IC) and amygdala to stimuli of positive and negative valence were found to be altered in patients with anxiety disorders. However, the coding properties of neurons controlling anxiety and valence remain …
View article: Expression of serotonin 1A and 2A receptors in molecular- and projection-defined neurons of the mouse insular cortex
Expression of serotonin 1A and 2A receptors in molecular- and projection-defined neurons of the mouse insular cortex Open
The serotonin (5-HT) system is the target of multiple anxiolytics, including Buspirone, which is a partial agonist of the serotonin 1A receptor (5-HT1A). Similarly, ligands of the serotonin 2A receptor (5-HT2A) were shown to alter anxiety …
View article: Expression of serotonin 1A and 2A receptors in molecular- and projection-defined neurons of the mouse insular cortex
Expression of serotonin 1A and 2A receptors in molecular- and projection-defined neurons of the mouse insular cortex Open
The serotonin (5-HT) system is the target of multiple anxiolytics, including Buspirone, which is a partial agonist of the serotonin 1A receptor (5‑HT1A). Similarly, ligands of the serotonin 2A receptor (5-HT2A) were shown to alter anxiety …
View article: Expression of serotonin 1A and 2A receptors in molecular- and projection-defined neurons of the mouse insular cortex
Expression of serotonin 1A and 2A receptors in molecular- and projection-defined neurons of the mouse insular cortex Open
The serotonin (5-HT) system is the target of multiple anxiolytics, including Buspirone, which is a partial agonist of the serotonin 1A receptor (5‑HT1A). Similarly, ligands of the serotonin 2A receptor (5-HT2A) were shown to alter anxiety …
View article: Expression of serotonin 1A and 2A receptors in molecular- and projection-defined neurons of the mouse insular cortex
Expression of serotonin 1A and 2A receptors in molecular- and projection-defined neurons of the mouse insular cortex Open
The serotonin (5-HT) system is the target of multiple anxiolytics, including Buspirone, which is a partial agonist of the serotonin 1A receptor (5‑HT1A). Similarly, ligands of the serotonin 2A receptor (5-HT2A) were shown to alter anxiety …
View article: Additional file 4 of Expression of serotonin 1A and 2A receptors in molecular- and projection-defined neurons of the mouse insular cortex
Additional file 4 of Expression of serotonin 1A and 2A receptors in molecular- and projection-defined neurons of the mouse insular cortex Open
Additional file 4: TableS1. Raw numbers of CTB-labelled cells and 5-HT1A+ or 2A+ CTB-labelled cells in the anterior and posterior insula.
View article: Physiological and pathophysiological homeostasis of astroglial channel proteins by Nedd4-2
Physiological and pathophysiological homeostasis of astroglial channel proteins by Nedd4-2 Open
Nedd4-2 is an E3 ubiquitin ligase, missense mutation of which is related to familial epilepsy, indicating its critical role in regulating neuronal network activity. However, Nedd4-2 substrates involved in neuronal network function have yet…
View article: Characterization of Ambra1 heterozygous mice as genetic mouse model of female-specific autism
Characterization of Ambra1 heterozygous mice as genetic mouse model of female-specific autism Open
Autism is known as a heritable neurodevelopmental disorder, diagnosed prior to the age of three years in humans based on three major domains: (1) impairment in social interaction (2) communication deficits (3) restricted interests and repe…