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View article: DNA damage response of U2OS cells to low doses of gamma radiation delivered at very low dose rate
DNA damage response of U2OS cells to low doses of gamma radiation delivered at very low dose rate Open
The DNA damage response (DDR) of cells to low dose and low dose rate ionizing radiation is weak and remains a matter of controversy. The response can be studied by exposing cells to a low adapting dose (AD) and, subsequently to a high chal…
View article: Editorial for Special Issue “Phytochemicals in Cancer Chemoprevention and Treatment”
Editorial for Special Issue “Phytochemicals in Cancer Chemoprevention and Treatment” Open
Despite significant progress in the treatment of cancer patients, modern oncological therapy faces numerous challenges that are primarily related to the lack of response to treatment caused by the resistance of cancer cells to chemotherape…
View article: No evidence of the long-term <i>in vitro</i> toxicity of Aeroxide P25 TiO<sub>2</sub> nanoparticles in three mammalian cell lines despite the initial reduction of cellular mitochondrial activity
No evidence of the long-term <i>in vitro</i> toxicity of Aeroxide P25 TiO<sub>2</sub> nanoparticles in three mammalian cell lines despite the initial reduction of cellular mitochondrial activity Open
We studied the effects of Aeroxide P25 titanium dioxide nanoparticles (TiO 2 NPs) with a diameter of 21 nm on induction of DNA damage and long-term survival of three human cell lines: hepatocellular liver carcinoma HepG2, colorectal adenoc…
View article: The DNA damage response to radiological imaging: from ROS and γH2AX foci induction to gene expression responses in vivo
The DNA damage response to radiological imaging: from ROS and γH2AX foci induction to gene expression responses in vivo Open
View article: The DNA damage response to radiological imaging: from ROS and γH2AX foci induction to gene expression responses in vivo
The DNA damage response to radiological imaging: from ROS and γH2AX foci induction to gene expression responses in vivo Open
Candidate ionising radiation exposure biomarkers must be validated in humans exposed in vivo . Blood from patients undergoing positron emission tomography - computed tomography scan (PET-CT) and skeletal scintigraphy (scintigraphy) was dra…
View article: Hypothermia differentially modulates the formation and decay of NBS1, γH2AX and 53BP1 foci in U2OS cells exposed to gamma radiation
Hypothermia differentially modulates the formation and decay of NBS1, γH2AX and 53BP1 foci in U2OS cells exposed to gamma radiation Open
In studies on the mechanism of DNA damage response where ionizing radiation is used as the DNA damaging agent, cells are often exposed to ionizing radiation on melting ice (corresponding to 0.8 °C). The purpose of this procedure is to inhi…
View article: Could veterinarians be immune to contracting SARS-CoV-2?
Could veterinarians be immune to contracting SARS-CoV-2? Open
None of the veterinarians had a significant increase in T lymphocytes, which could be an effective defense against SARS-CoV-2.
View article: Cisplatin Reduces the Frequencies of Radiotherapy-Induced Micronuclei in Peripheral Blood Lymphocytes of Patients with Gynaecological Cancer: Possible Implications for the Risk of Second Malignant Neoplasms
Cisplatin Reduces the Frequencies of Radiotherapy-Induced Micronuclei in Peripheral Blood Lymphocytes of Patients with Gynaecological Cancer: Possible Implications for the Risk of Second Malignant Neoplasms Open
Gynaecologic cancers are common among women and treatment includes surgery, radiotherapy or chemotherapy, where the last two methods induce DNA damage in non-targeted cells like peripheral blood lymphocytes (PBL). Damaged normal cells can …
View article: Coralyne Radiosensitizes A549 Cells by Upregulation of CDKN1A Expression to Attenuate Radiation Induced G2/M Block of the Cell Cycle
Coralyne Radiosensitizes A549 Cells by Upregulation of CDKN1A Expression to Attenuate Radiation Induced G2/M Block of the Cell Cycle Open
Coralyne is a synthetic analog of berberine related to protoberberine-isoquinoline alkaloids. Isoquinoline derivatives and analogs are renowned as potent radiosensitizers with potential medical application. In the present study, we investi…
View article: Targeted Radionuclide Therapy of Prostate Cancer—From Basic Research to Clinical Perspectives
Targeted Radionuclide Therapy of Prostate Cancer—From Basic Research to Clinical Perspectives Open
Prostate cancer is the most commonly diagnosed malignancy in men and the second leading cause of cancer-related deaths in Western civilization. Although localized prostate cancer can be treated effectively in different ways, almost all pat…
View article: Selective cytotoxicity and antifungal properties of copper(II) and cobalt(II) complexes with imidazole-4-acetate anion or 1-allylimidazole
Selective cytotoxicity and antifungal properties of copper(II) and cobalt(II) complexes with imidazole-4-acetate anion or 1-allylimidazole Open
View article: ANTIOXIDANT DEFENSE PARAMETERS IN TESTES OF ADULT MALE RATS AFTER EXPOSURE TO EXHAUST EMISSION FROM 2ND GENERATION BIODIESEL
ANTIOXIDANT DEFENSE PARAMETERS IN TESTES OF ADULT MALE RATS AFTER EXPOSURE TO EXHAUST EMISSION FROM 2ND GENERATION BIODIESEL Open
Increased use of 1st and 2nd generation biofuels raises concerns about health effects of new emissions. We analyzed cellular and molecular lung effects in Fisher 344 rats exposed to diesel engine exhaust emissions (DEE) from a Euro 5-class…
View article: Genotoxic potential of diesel exhaust particles from the combustion of first- and second-generation biodiesel fuels—the FuelHealth project
Genotoxic potential of diesel exhaust particles from the combustion of first- and second-generation biodiesel fuels—the FuelHealth project Open
Epidemiological data indicate that exposure to diesel exhaust particles (DEPs) from traffic emissions is associated with higher risk of morbidity and mortality related to cardiovascular and pulmonary diseases, accelerated progression of at…
View article: A comparative analysis of in vitro toxicity of diesel exhaust particles from combustion of 1st- and 2nd-generation biodiesel fuels in relation to their physicochemical properties—the FuelHealth project
A comparative analysis of in vitro toxicity of diesel exhaust particles from combustion of 1st- and 2nd-generation biodiesel fuels in relation to their physicochemical properties—the FuelHealth project Open
Biodiesels represent more carbon-neutral fuels and are introduced at an increasing extent to reduce emission of greenhouse gases. However, the potential impact of different types and blend concentrations of biodiesel on the toxicity of die…
View article: Searching for in vitro biomarkers of susceptibility to prostate and cervical cancers by analysis of chromosomal instability, γ-H2AX foci, polymorphisms in DNA repair genes and apoptosis
Searching for in vitro biomarkers of susceptibility to prostate and cervical cancers by analysis of chromosomal instability, γ-H2AX foci, polymorphisms in DNA repair genes and apoptosis Open
1. Hagmar L, Bonassi S, Strömberg U, Mikoczy Z, Lando C, Hansteen I-L, Montagud AH, Knudsen L, Norppa H, Reuterwall Ch, Tinnerberg H, Brøgger A, Forni A, Högstedt B, Lambert B, Mitelman F, Nordenson I, Salomaa S, Skerfving S. Canser predic…
View article: The effects of nickel(II) complexes with imidazole derivatives on pyocyanin and pyoverdine production by Pseudomonas aeruginosa strains isolated from cystic fibrosis
The effects of nickel(II) complexes with imidazole derivatives on pyocyanin and pyoverdine production by Pseudomonas aeruginosa strains isolated from cystic fibrosis Open
Pseudomonas aeruginosa infection is problematic in patients with cystic fibrosis (CF). P. aeruginosa secretes a diversity of pigments, such as pyocyanin and pyoverdine. The aim of this study was to evaluate the effects of complexes of nick…