Ángela B. Moragrega
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View article: Rilpivirine Activates STAT1 in Non-Parenchymal Cells to Regulate Liver Injury in People Living with HIV and MASLD
Rilpivirine Activates STAT1 in Non-Parenchymal Cells to Regulate Liver Injury in People Living with HIV and MASLD Open
Liver fibrosis is a key determinant of the progression of metabolic dysfunction-associated steatotic liver disease (MASLD). Its increasing prevalence and a lack of effective treatments make it a major health problem worldwide, particularly…
View article: Anti-inflammatory and immunomodulating effects of rilpivirine: Relevance for the therapeutics of chronic liver disease
Anti-inflammatory and immunomodulating effects of rilpivirine: Relevance for the therapeutics of chronic liver disease Open
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease (CLD) worldwide and inflammation is key to its progression/resolution. As we have previously described that rilpivirine (RPV) is hepatoprotective i…
View article: Down-Regulation of the Longevity-Associated Protein SIRT1 in Peripheral Blood Mononuclear Cells of Treated HIV Patients
Down-Regulation of the Longevity-Associated Protein SIRT1 in Peripheral Blood Mononuclear Cells of Treated HIV Patients Open
The activity of sirtuin 1 (SIRT1), a class III histone deacetylase with a critical role in several biological functions, decreases with age and its deficiency is associated with many inflammatory and age-related diseases. It also regulates…
View article: Understanding the implication of autophagy in the activation of hepatic stellate cells in liver fibrosis: are we there yet?
Understanding the implication of autophagy in the activation of hepatic stellate cells in liver fibrosis: are we there yet? Open
Liver fibrosis (LF) occurs as a result of persistent liver injury and can be defined as a pathologic, chronic, wound‐healing process in which functional parenchyma is progressively replaced by fibrotic tissue. As a phenomenon involved in t…
View article: Apoptosis of Hepatocytes: Relevance for HIV-Infected Patients under Treatment
Apoptosis of Hepatocytes: Relevance for HIV-Infected Patients under Treatment Open
Due to medical advances over the past few decades, human immunodeficiency virus (HIV) infection, once a devastatingly mortal pandemic, has become a manageable chronic condition. However, available antiretroviral treatments (cART) cannot fu…
View article: Role of p62/SQSTM1 beyond autophagy: a lesson learned from drug‐induced toxicity <i>in vitro</i>
Role of p62/SQSTM1 beyond autophagy: a lesson learned from drug‐induced toxicity <i>in vitro</i> Open
Background and Purpose SQSTM1/p62 is a multifunctional, stress‐induced, scaffold protein involved in multiple cellular processes including autophagic clearance, regulation of inflammatory responses and redox homeostasis. Its altered functi…
View article: Lon protease: a novel mitochondrial matrix protein in the interconnection between drug‐induced mitochondrial dysfunction and endoplasmic reticulum stress
Lon protease: a novel mitochondrial matrix protein in the interconnection between drug‐induced mitochondrial dysfunction and endoplasmic reticulum stress Open
Background and Purpose Mitochondria‐associated membranes (MAMs) are specific endoplasmic reticulum (ER) domains that enable it to interact directly with mitochondria and mediate metabolic flow and Ca 2+ transfer. A growing list of proteins…