Angela C. Bustamante
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View article: Polygenic and developmental profiles of autism differ by age at diagnosis
Polygenic and developmental profiles of autism differ by age at diagnosis Open
Although autism has historically been conceptualized as a condition that emerges in early childhood 1,2 , many autistic people are diagnosed later in life 3–5 . It is unknown whether earlier- and later-diagnosed autism have different devel…
View article: Perceiving Retinal Progress: From Anatomy to Bioengineering Organoids
Perceiving Retinal Progress: From Anatomy to Bioengineering Organoids Open
The retina, a crucial part of the eye, is made up of various cells and structures that are essential for the conversion of a light stimulus into an electric signal for the brain to develop an image. The different cells of the retina includ…
View article: Systems biology dissection of PTSD and MDD across brain regions, cell types, and blood
Systems biology dissection of PTSD and MDD across brain regions, cell types, and blood Open
The molecular pathology of stress-related disorders remains elusive. Our brain multiregion, multiomic study of posttraumatic stress disorder (PTSD) and major depressive disorder (MDD) included the central nucleus of the amygdala, hippocamp…
View article: Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder
Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder Open
View article: Potential causal association between gut microbiome and posttraumatic stress disorder
Potential causal association between gut microbiome and posttraumatic stress disorder Open
View article: Discovery of 95 PTSD loci provides insight into genetic architecture and neurobiology of trauma and stress-related disorders
Discovery of 95 PTSD loci provides insight into genetic architecture and neurobiology of trauma and stress-related disorders Open
Posttraumatic stress disorder (PTSD) genetics are characterized by lower discoverability than most other psychiatric disorders. The contribution to biological understanding from previous genetic studies has thus been limited. We performed …
View article: Pneumosepsis survival in the setting of obesity leads to persistent steatohepatitis and metabolic dysfunction
Pneumosepsis survival in the setting of obesity leads to persistent steatohepatitis and metabolic dysfunction Open
Background: As critical care practice evolves, the sepsis survivor population continues to expand, often with lingering inflammation in many organs, including the liver. Given the concurrently increasing population of patients with NAFLD, …
View article: DNA sequencing in the classroom: complete genome sequence of two earwig (Dermaptera; Insecta) species
DNA sequencing in the classroom: complete genome sequence of two earwig (Dermaptera; Insecta) species Open
View article: Rare copy number variation in posttraumatic stress disorder
Rare copy number variation in posttraumatic stress disorder Open
View article: The Relationship of Attention-Deficit/Hyperactivity Disorder With Posttraumatic Stress Disorder: A Two-Sample Mendelian Randomization and Population-Based Sibling Comparison Study
The Relationship of Attention-Deficit/Hyperactivity Disorder With Posttraumatic Stress Disorder: A Two-Sample Mendelian Randomization and Population-Based Sibling Comparison Study Open
View article: Analysis of lumbar spine stenosis specimens for identification of amyloid
Analysis of lumbar spine stenosis specimens for identification of amyloid Open
Background Lumbar spinal stenosis (LSS) is a common reason for spine surgery in which ligamentum flavum is resected. Transthyretin (TTR) amyloid is an often unrecognized and potentially modifiable mechanism for LSS that can also cause TTR …
View article: 51: Cystic fibrosis mortality trends in Mexico
51: Cystic fibrosis mortality trends in Mexico Open
View article: Enhancing Discovery of Genetic Variants for Posttraumatic Stress Disorder Through Integration of Quantitative Phenotypes and Trauma Exposure Information
Enhancing Discovery of Genetic Variants for Posttraumatic Stress Disorder Through Integration of Quantitative Phenotypes and Trauma Exposure Information Open
Through using a quantitative trait measure of PTSD, we identified novel risk loci not previously identified using prior case-control analyses. PTSD and LTE have a high genetic overlap that can be leveraged to increase discovery power throu…
View article: Long-term survivors of murine sepsis are predisposed to enhanced LPS-induced lung injury and proinflammatory immune reprogramming
Long-term survivors of murine sepsis are predisposed to enhanced LPS-induced lung injury and proinflammatory immune reprogramming Open
Millions of people who survive sepsis each year are rehospitalized and die due to late pulmonary complications. To prevent and treat these complications, biomarkers and molecular mediators must be identified. Persistent immune reprogrammin…
View article: Behavioral, Cognitive, and Transcriptomic Impact of Sepsis in a Murine Model of Alzheimer’s Disease
Behavioral, Cognitive, and Transcriptomic Impact of Sepsis in a Murine Model of Alzheimer’s Disease Open
View article: Mechanisms of Long-Term Pulmonary Complications After Sepsis: Evaluating Persistent S100A8/A9 in Humans and Mice
Mechanisms of Long-Term Pulmonary Complications After Sepsis: Evaluating Persistent S100A8/A9 in Humans and Mice Open
View article: Body Composition and Hepatic Inflammation in Obese Pneumonia Survivors
Body Composition and Hepatic Inflammation in Obese Pneumonia Survivors Open
View article: Associations between childhood family emotional health, fronto-limbic grey matter volume, and saliva 5mC in young adulthood
Associations between childhood family emotional health, fronto-limbic grey matter volume, and saliva 5mC in young adulthood Open
Background Poor family emotional health (FEH) during childhood is prevalent and impactful, and likely confers similar neurodevelopmental risks as other adverse social environments. Pointed FEH study efforts are underdeveloped, and the mech…
View article: Additional file 1 of Associations between childhood family emotional health, fronto-limbic grey matter volume, and saliva 5mC in young adulthood
Additional file 1 of Associations between childhood family emotional health, fronto-limbic grey matter volume, and saliva 5mC in young adulthood Open
Additional file 1: Supplementary Tables. Table S1. FEH predicts MEs. Table S2. MEs predict BRV. Table S3. Probe specific annotations. Table S4. Probe-wise mediation. Table S5. Condensed GSEA. Table S6. Cohort-level mental health diagnoses.…
View article: DICER1 and microRNA regulation in post-traumatic stress disorder with comorbid depression
DICER1 and microRNA regulation in post-traumatic stress disorder with comorbid depression Open
DICER1 is an enzyme that generates mature microRNAs (miRNAs), which regulate gene expression post-transcriptionally in brain and other tissues and is involved in synaptic maturation and plasticity. Here, through genome-wide differential ge…
View article: Associations between childhood family emotional health, fronto-limbic grey matter volume, and saliva 5mC in young adulthood
Associations between childhood family emotional health, fronto-limbic grey matter volume, and saliva 5mC in young adulthood Open
Background Poor family emotional health (FEH) during childhood is prevalent and impactful, and likely confers similar neurodevelopmental risks as other adverse social environments. Pointed FEH study efforts are underdeveloped, and the mech…
View article: Glucocorticoid receptor DNA methylation, childhood maltreatment and major depression
Glucocorticoid receptor DNA methylation, childhood maltreatment and major depression Open
Altered DNA methylation (DNAm) levels of hypothalamic-pituitary-adrenal (HPA) axis genes has been associated with exposure to childhood maltreatment (CM) and depression; however, it is unknown whether CM and depression have joint and poten…
View article: Transcriptomic Profiles of Sepsis in the Human Brain
Transcriptomic Profiles of Sepsis in the Human Brain Open
View article: Molecular genetic overlap between posttraumatic stress disorder and sleep phenotypes
Molecular genetic overlap between posttraumatic stress disorder and sleep phenotypes Open
Study Objectives Sleep problems are common, serving as both a predictor and symptom of posttraumatic stress disorder (PTSD), with these bidirectional relationships well established in the literature. While both sleep phenotypes and PTSD ar…
View article: International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci
International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci Open
View article: A high methyl donor diet affects physiology and behavior in Peromyscus polionotus
A high methyl donor diet affects physiology and behavior in Peromyscus polionotus Open
View article: Largest genome-wide association study for PTSD identifies genetic risk loci in European and African ancestries and implicates novel biological pathways
Largest genome-wide association study for PTSD identifies genetic risk loci in European and African ancestries and implicates novel biological pathways Open
Post-traumatic stress disorder (PTSD) is a common and debilitating disorder. The risk of PTSD following trauma is heritable, but robust common variants have yet to be identified by genome-wide association studies (GWAS). We have collected …
View article: Inhibition of DNA Methylation With Zebularine Alters Lipopolysaccharide-Induced Sickness Behavior and Neuroinflammation in Mice
Inhibition of DNA Methylation With Zebularine Alters Lipopolysaccharide-Induced Sickness Behavior and Neuroinflammation in Mice Open
Activity of DNA methyltransferases (DNMTs), the enzymes that catalyze DNA methylation, is dynamically regulated in the brain. DNMT inhibitors alter DNA methylation globally in the brain and at individual neural plasticity-associated genes,…
View article: Acknowledgments
Acknowledgments Open
View article: Correction: Corrigendum: DICER1 and microRNA regulation in post-traumatic stress disorder with comorbid depression
Correction: Corrigendum: DICER1 and microRNA regulation in post-traumatic stress disorder with comorbid depression Open
Nature Communications 6: Article number: 10106 (2015); Published: 3 December 2015; Updated: 3 March 2016 The original version of this Article contained an error in the spelling of the author Jennifer S. Stevens, which was incorrectly given…