David Kerrigan
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View article: IBC Oxford University Oral Abstract 3 - Audit of outcome of SADIS- results from a single bariatric centre
IBC Oxford University Oral Abstract 3 - Audit of outcome of SADIS- results from a single bariatric centre Open
Introduction Obesity is a growing concern globally. Surgical treatment of obesity includes Sleeve gastrectomy and Gastric bypass. These procedures can suffer inadequate weight loss and weight re-gain. SADIS- Single anastomosis Duodeno-ilea…
View article: NSm is a critical determinant for bunyavirus transmission between vertebrate and arthropod hosts
NSm is a critical determinant for bunyavirus transmission between vertebrate and arthropod hosts Open
Bunyavirales is a very large order including viruses infecting a variety of taxonomic groups such as arthropods, vertebrates, plants, and protozoan. Some bunyaviruses are transmitted between vertebrate hosts by blood-sucking arthropods and…
View article: Metabolic adaptation following gastric bypass surgery: Results from a 2-year observational study.
Metabolic adaptation following gastric bypass surgery: Results from a 2-year observational study. Open
Background/Objectives: Metabolic adaptation is the lowering of basal metabolic rate (BMR) beyond what is predicted from changes in fat mass (FM) and fat-free mass (FFM) and may hamper weight-loss progression. It is unclear whether metaboli…
View article: Early Changes in Observed Eating Behaviours and Suboptimal Weight Loss in Gastric Bypass Patients: Preliminary Findings
Early Changes in Observed Eating Behaviours and Suboptimal Weight Loss in Gastric Bypass Patients: Preliminary Findings Open
Bariatric surgery is the most effective long-term treatment for severe obesity [...]
View article: The first international Delphi consensus statement on Laparoscopic Gastrointestinal surgery
The first international Delphi consensus statement on Laparoscopic Gastrointestinal surgery Open
Thirty-eight experts achieved a consensus on 133 statements concerning various aspects of laparoscopic GI Surgery. Increased awareness of these could facilitate training and improve patient outcomes.
View article: Defining the Role of Nuclear Factor (NF)-κB p105 Subunit in Human Macrophage by Transcriptomic Analysis of NFKB1 Knockout THP1 Cells
Defining the Role of Nuclear Factor (NF)-κB p105 Subunit in Human Macrophage by Transcriptomic Analysis of NFKB1 Knockout THP1 Cells Open
Since its discovery over 30 years ago the NF-ĸB family of transcription factors has gained the status of master regulator of the immune response. Much of what we understand of the role of NF-ĸB in immune development, homeostasis and inflam…
View article: Bariatric surgery for patients with type 2 diabetes mellitus requiring insulin: Clinical outcome and cost-effectiveness analyses
Bariatric surgery for patients with type 2 diabetes mellitus requiring insulin: Clinical outcome and cost-effectiveness analyses Open
Background Although bariatric surgery is well established as an effective treatment for patients with obesity and type 2 diabetes mellitus (T2DM), there exists reluctance to increase its availability for patients with severe T2DM. The aims…
View article: The IκB-protein BCL-3 controls Toll-like receptor-induced MAPK activity by promoting TPL-2 degradation in the nucleus
The IκB-protein BCL-3 controls Toll-like receptor-induced MAPK activity by promoting TPL-2 degradation in the nucleus Open
Significance The NF-ĸB and mitogen-activated protein kinase (MAPK) pathways coordinate the cellular response to most immune stimuli. Toll-like (TLR) and TNF receptor activation of the MAPK pathway requires activation of the TPL-2 kinase. A…
View article: The regulation of sequence specific NF-κB DNA binding and transcription by IKKβ phosphorylation of NF-κB p50 at serine 80
The regulation of sequence specific NF-κB DNA binding and transcription by IKKβ phosphorylation of NF-κB p50 at serine 80 Open
Phosphorylation of the NF-κB transcription factor is an important regulatory mechanism for the control of transcription. Here we identify serine 80 (S80) as a phosphorylation site on the p50 subunit of NF-κB, and IKKβ as a p50 kinase. Tran…
View article: The IκB-Protein BCL-3 Controls MAPK Activity by Promoting TPL-2 Degradation in the Nucleus
The IκB-Protein BCL-3 Controls MAPK Activity by Promoting TPL-2 Degradation in the Nucleus Open
The ability of the innate immune system to distinguish between low level microbial presence and invasive pathogens is fundamental for immune homeostasis and immunity. However, the molecular mechanisms underlying threat discrimination by in…
View article: Abstracts of the 7th BOMSS Annual Scientific Meeting, 28–29 January 2016, City Hall, Cardiff
Abstracts of the 7th BOMSS Annual Scientific Meeting, 28–29 January 2016, City Hall, Cardiff Open
Background: Mortality after Roux-en-Y Gastric Bypass (RYGB) in high risk patients [Obesity Surgery Mortality Risk Score (OSMRS) 4-5] has been shown in several large validation studies to be 2 to 3%.As BMI is a modifiable risk factor, stage…