Angela Halfmann
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View article: PI3K Signaling in Dendritic Cells Aggravates DSS-Induced Colitis
PI3K Signaling in Dendritic Cells Aggravates DSS-Induced Colitis Open
Aberrant innate immune responses to the gut microbiota are causally involved in the pathogenesis of inflammatory bowel diseases (IBD). The exact triggers and main signaling pathways activating innate immune cells and how they modulate adap…
View article: JAK1 signaling in dendritic cells promotes peripheral tolerance in autoimmunity through PD-L1-mediated regulatory T cell induction
JAK1 signaling in dendritic cells promotes peripheral tolerance in autoimmunity through PD-L1-mediated regulatory T cell induction Open
Dendritic cells (DCs) induce peripheral T cell tolerance, but cell-intrinsic signaling cascades governing their stable tolerogenesis remain poorly defined. Janus Kinase 1 (JAK1) transduces cytokine-receptor signaling, and JAK inhibitors (J…
View article: EPEN-21. IMPAIRED NEURONAL-GLIAL FATE SPECIFICATION IN PEDIATRIC EPENDYMOMA REVEALED BY SINGLE-CELL RNA-SEQ
EPEN-21. IMPAIRED NEURONAL-GLIAL FATE SPECIFICATION IN PEDIATRIC EPENDYMOMA REVEALED BY SINGLE-CELL RNA-SEQ Open
Ependymoma represents a heterogeneous disease affecting the entire neuraxis. Extensive molecular profiling efforts have identified molecular ependymoma subgroups based on DNA methylation. However, the intratumoral heterogeneity and develop…
View article: EPCO-35. SINGLE-CELL RNA-SEQ OF PEDIATRIC EPENDYMOMA REVEALS PROGNOSTIC IMPACT OF IMPAIRED NEURONAL-GLIAL FATE SPECIFICATION
EPCO-35. SINGLE-CELL RNA-SEQ OF PEDIATRIC EPENDYMOMA REVEALS PROGNOSTIC IMPACT OF IMPAIRED NEURONAL-GLIAL FATE SPECIFICATION Open
Ependymoma represents a heterogeneous disease affecting the entire neuraxis. Extensive molecular profiling efforts have identified molecular ependymoma subgroups based on DNA methylation. However, the intratumoral heterogeneity and develop…
View article: PDTM-32. RESOLVING MEDULLOBLASTOMA CELLULAR ARCHITECTURE BY SINGLE-CELL GENOMICS
PDTM-32. RESOLVING MEDULLOBLASTOMA CELLULAR ARCHITECTURE BY SINGLE-CELL GENOMICS Open
Medulloblastoma is a malignant childhood cerebellar tumor comprised of distinct molecular subgroups. Whereas genomic characteristics of these subgroups are well defined, the extent to which cellular diversity underlies their divergent biol…
View article: Gliomasphere marker combinatorics: multidimensional flow cytometry detects <scp>CD</scp>44+/<scp>CD</scp>133+/<scp>ITGA</scp>6+/<scp>CD</scp>36+ signature
Gliomasphere marker combinatorics: multidimensional flow cytometry detects <span>CD</span>44+/<span>CD</span>133+/<span>ITGA</span>6+/<span>CD</span>36+ signature Open
Glioblastoma is the most dangerous brain cancer. One reason for glioblastoma's aggressiveness are glioblastoma stem‐like cells. To target them, a number of markers have been proposed ( CD 133, CD 44, CD 15, A2B5, CD 36, CXCR 4, IL 6R, L1 C…
View article: Cover Feature: A pH‐sensitive Macromolecular Prodrug as TLR7/8 Targeting Immune Response Modifier (Chem. Eur. J. 70/2017)
Cover Feature: A pH‐sensitive Macromolecular Prodrug as TLR7/8 Targeting Immune Response Modifier (Chem. Eur. J. 70/2017) Open
The chemical synthesis and biological activity of new functionalized imidazoquinoline derivatives (ImQ) to generate Toll-like receptor (TLR) 7/8 specific prodrugs are presented. In vivo activity of ImQs to induce inflammation was confirmed…
View article: CD28 Blockade Ex Vivo Induces Alloantigen-Specific Immune Tolerance but Preserves T-Cell Pathogen Reactivity
CD28 Blockade Ex Vivo Induces Alloantigen-Specific Immune Tolerance but Preserves T-Cell Pathogen Reactivity Open
Donor T-cells contribute to reconstitution of protective immunity after allogeneic hematopoietic stem cell transplantation (HSCT) but must acquire specific tolerance against recipient alloantigens to avoid life-threatening graft-versus-hos…
View article: A pH‐sensitive Macromolecular Prodrug as TLR7/8 Targeting Immune Response Modifier
A pH‐sensitive Macromolecular Prodrug as TLR7/8 Targeting Immune Response Modifier Open
The chemical synthesis and biological activity of novel functionalized imidazoquinoline derivatives (ImQ) to generate Toll‐like receptor (TLR) 7/8 specific prodrugs are presented. In vivo activity of ImQs to induce inflammation was confirm…
View article: Myeloid PTEN deficiency impairs tumor-immune surveillance via immune-checkpoint inhibition
Myeloid PTEN deficiency impairs tumor-immune surveillance via immune-checkpoint inhibition Open
Tumor-host interaction is determined by constant immune surveillance, characterized by tumor infiltration of myeloid and lymphoid cells. A malfunctioning or diverted immune response promotes tumor growth and metastasis. Recent advances had…